Reviewed,
UniProtKB/Swiss-Prot P64461 (LSRG_ECOLI)
Last modified
November 25, 2008.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Autoinducer 2-degrading protein lsrG Short name=AI-2-degrading protein lsrG | ||||||
| Gene names |
| ||||||
| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 96 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5-dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound. |
| Subcellular location | CytoplasmPotential. |
| Induction | In the absence of AI-2, repressed by lsrR. Induced by AI-2, via release of the lsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. |
| Sequence similarities | Belongs to the lsrG family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | antibiotic biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | oxidoreductase activity Inferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 96 | 96 | Autoinducer 2-degrading protein lsrG | PRO_0000168947 | |||
Sequences
References
Cross-references
Sequence databases | |
|---|---|
| U00096 Genomic DNA. Translation: AAC74591.1. AP009048 Genomic DNA. Translation: BAE76458.1. | |
| PIR | A64906. |
| RefSeq | AP_002139.1. NP_416035.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P64461. |
Genome annotation databases | |
| GeneID | 946073. |
| GenomeReviews | Gene locus b1518 in contig U00096_GR. Gene locus JW1511 in contig AP009048_GR. |
| KEGG | ecj:JW1511. eco:b1518. |
Organism-specific databases | |
| EchoBASE | EB3572. |
| EcoGene | EG13811. lsrG. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P64461. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:G6805-MON. |
Family and domain databases | |
| InterPro | IPR007138. Antibiotic_mOase. [Graphical view] |
| Pfam | PF03992. ABM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LSRG_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P64461 Secondary accession number(s): P76144, Q2MB98 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with


