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P64461

- LSRG_ECOLI

UniProt

P64461 - LSRG_ECOLI

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Protein
Autoinducer 2-degrading protein LsrG
Gene
lsrG, yneC, b1518, JW1511
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5-dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound.1 Publication

GO - Molecular functioni

  1. catalytic activity Source: EcoCyc
Complete GO annotation...

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6805-MONOMER.
ECOL316407:JW1511-MONOMER.
MetaCyc:G6805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Autoinducer 2-degrading protein LsrG
Short name:
AI-2-degrading protein LsrG
Gene namesi
Name:lsrG
Synonyms:yneC
Ordered Locus Names:b1518, JW1511
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13811. lsrG.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9696Autoinducer 2-degrading protein LsrG
PRO_0000168947Add
BLAST

Expressioni

Inductioni

In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter.2 Publications

Gene expression databases

GenevestigatoriP64461.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nadEP188431EBI-1124339,EBI-548960

Protein-protein interaction databases

DIPiDIP-47853N.
IntActiP64461. 5 interactions.
STRINGi511145.b1518.

Structurei

3D structure databases

ProteinModelPortaliP64461.

Family & Domainsi

Sequence similaritiesi

Belongs to the LsrG family.

Phylogenomic databases

eggNOGiCOG1359.
HOGENOMiHOG000145619.
KOiK11530.
OMAiASILTRI.
OrthoDBiEOG6K6VBX.

Family and domain databases

InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.

Sequencei

Sequence statusi: Complete.

P64461-1 [UniParc]FASTAAdd to Basket

« Hide

MHVTLVEINV HEDKVDEFIE VFRQNHLGSV QEEGNLRFDV LQDPEVNSRF   50
YIYEAYKDED AVAFHKTTPH YKTCVAKLES LMTGPRKKRL FNGLMP 96
Length:96
Mass (Da):11,255
Last modified:October 11, 2004 - v1
Checksum:i138099193F125EB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74591.1.
AP009048 Genomic DNA. Translation: BAE76458.1.
PIRiA64906.
RefSeqiNP_416035.1. NC_000913.3.
YP_489781.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74591; AAC74591; b1518.
BAE76458; BAE76458; BAE76458.
GeneIDi12931234.
946073.
KEGGiecj:Y75_p1493.
eco:b1518.
PATRICi32118332. VBIEscCol129921_1586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74591.1 .
AP009048 Genomic DNA. Translation: BAE76458.1 .
PIRi A64906.
RefSeqi NP_416035.1. NC_000913.3.
YP_489781.1. NC_007779.1.

3D structure databases

ProteinModelPortali P64461.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-47853N.
IntActi P64461. 5 interactions.
STRINGi 511145.b1518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74591 ; AAC74591 ; b1518 .
BAE76458 ; BAE76458 ; BAE76458 .
GeneIDi 12931234.
946073.
KEGGi ecj:Y75_p1493.
eco:b1518.
PATRICi 32118332. VBIEscCol129921_1586.

Organism-specific databases

EchoBASEi EB3572.
EcoGenei EG13811. lsrG.

Phylogenomic databases

eggNOGi COG1359.
HOGENOMi HOG000145619.
KOi K11530.
OMAi ASILTRI.
OrthoDBi EOG6K6VBX.

Enzyme and pathway databases

BioCyci EcoCyc:G6805-MONOMER.
ECOL316407:JW1511-MONOMER.
MetaCyc:G6805-MONOMER.

Miscellaneous databases

PROi P64461.

Gene expression databases

Genevestigatori P64461.

Family and domain databases

InterProi IPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
[Graphical view ]
Pfami PF03992. ABM. 1 hit.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
    Xavier K.B., Bassler B.L.
    J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
    Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
    J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria."
    Xavier K.B., Miller S.T., Lu W., Kim J.H., Rabinowitz J., Pelczer I., Semmelhack M.F., Bassler B.L.
    ACS Chem. Biol. 2:128-136(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHO-AI-2 DEGRADATION.

Entry informationi

Entry nameiLSRG_ECOLI
AccessioniPrimary (citable) accession number: P64461
Secondary accession number(s): P76144, Q2MB98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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