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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaKUniRule annotation
Alternative name(s):
HSP70UniRule annotation
Heat shock 70 kDa proteinUniRule annotation
Heat shock protein 70UniRule annotation
Gene namesi
Name:dnaKUniRule annotation
Ordered Locus Names:MW1532
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Chaperone protein DnaKPRO_0000078541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731Phosphothreonine; by autocatalysisUniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP64408.

Expressioni

Inductioni

By stress conditions e.g. heat shock.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP64408.
SMRiP64408. Positions 1-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228137.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVTVLE GDEPKVIQNP EGSRTTPSVV AFKNGETQVG
60 70 80 90 100
EVAKRQAITN PNTVQSIKRH MGTDYKVDIE GKSYTPQEIS AMILQNLKNT
110 120 130 140 150
AESYLGEKVD KAVITVPAYF NDAERQATKD AGKIAGLEVE RIINEPTAAA
160 170 180 190 200
LAYGLDKTDK DEKVLVFDLG GGTFDVSILE LGDGVFEVLS TAGDNKLGGD
210 220 230 240 250
DFDQVIIDYL VAEFKKENGV DLSQDKMALQ RLKDAAEKAK KDLSGVSQTQ
260 270 280 290 300
ISLPFISAGE NGPLHLEVNL TRSKFEELSD SLIRRTMEPT RQAMKDAGLT
310 320 330 340 350
NSDIDEVILV GGSTRIPAVQ EAVKKEIGKE PNKGVNPDEV VAMGAAIQGG
360 370 380 390 400
VITGDVKDVV LLDVTPLSLG IEILGGRMNT LIERNTTIPT SKSQIYSTAV
410 420 430 440 450
DNQPSVDVHV LQGERPMAAD NKTLGRFQLT DIPPAERGKP QIEVTFDIDK
460 470 480 490 500
NGIVNVTAKD LGTNKEQRIT IQSSSSLSDE EIDRMVKDAE VNAEADKKRR
510 520 530 540 550
EEVDLRNEAD SLVFQVEKTL TDLGENIGEE DKKSAEEKKD ALKTALEGQD
560 570 580 590 600
IEDIKSKKEE LEKVIQELSA KVYEQAAQQQ QQAQGANAGQ NNDSTVEDAE
610
FKEVKDDDKK
Length:610
Mass (Da):66,361
Last modified:October 11, 2004 - v1
Checksum:iB71645C36D26AAED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95397.1.
RefSeqiWP_000034716.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95397; BAB95397; BAB95397.
PATRICi19569674. VBIStaAur44266_1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95397.1.
RefSeqiWP_000034716.1. NC_003923.1.

3D structure databases

ProteinModelPortaliP64408.
SMRiP64408. Positions 1-568.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP64408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95397; BAB95397; BAB95397.
PATRICi19569674. VBIStaAur44266_1598.

Phylogenomic databases

HOGENOMiHOG000228137.
OMAiEKMAPPQ.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1556-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_STAAW
AccessioniPrimary (citable) accession number: P64408
Secondary accession number(s): Q99TR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.