Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat-inducible transcription repressor HrcA

Gene

hrcA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-inducible transcription repressor HrcAUniRule annotation
Gene namesi
Name:hrcAUniRule annotation
Ordered Locus Names:BR0172, BS1330_I0172
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Heat-inducible transcription repressor HrcAPRO_0000182459Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the HrcA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1420.
HOGENOMiHOG000058933.
KOiK03705.
OrthoDBiEOG632D4G.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPiMF_00081. HrcA.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.

Sequencei

Sequence statusi: Complete.

P64397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP
60 70 80 90 100
ATIRNVMSDL EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER
110 120 130 140 150
SSIEAQVRAA GTSNSVESVL TEASQVLSGL SRGAGLVLTN KTDVALKHIE
160 170 180 190 200
FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG ISTSQLIEAS NFLNAHIHGH
210 220 230 240 250
TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA DQPARLIVRG
260 270 280 290 300
RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE
310 320 330 340 350
NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI

VSRLLR
Length:356
Mass (Da):39,094
Last modified:October 11, 2004 - v1
Checksum:i1F72BCC0E77A2FB7
GO

Sequence cautioni

The sequence AAN29125.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AEM17537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
RefSeqiWP_002965420.1. NZ_KN046804.1.

Genome annotation databases

EnsemblBacteriaiAAN29125; AAN29125; BR0172.
AEM17537; AEM17537; BS1330_I0172.
GeneIDi3788756.
KEGGibms:BR0172.
bsi:BS1330_I0172.
PATRICi17788612. VBIBruSui107850_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
RefSeqiWP_002965420.1. NZ_KN046804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29125; AAN29125; BR0172.
AEM17537; AEM17537; BS1330_I0172.
GeneIDi3788756.
KEGGibms:BR0172.
bsi:BS1330_I0172.
PATRICi17788612. VBIBruSui107850_0179.

Phylogenomic databases

eggNOGiCOG1420.
HOGENOMiHOG000058933.
KOiK03705.
OrthoDBiEOG632D4G.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPiMF_00081. HrcA.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiHRCA_BRUSU
AccessioniPrimary (citable) accession number: P64397
Secondary accession number(s): G0KBE5, Q8YEV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.