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P64397

- HRCA_BRUSU

UniProt

P64397 - HRCA_BRUSU

Protein

Heat-inducible transcription repressor HrcA

Gene

hrcA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. response to stress Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat-inducible transcription repressor HrcAUniRule annotation
    Gene namesi
    Name:hrcAUniRule annotation
    Ordered Locus Names:BR0172, BS1330_I0172
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Heat-inducible transcription repressor HrcAPRO_0000182459Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR0172.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HrcA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1420.
    HOGENOMiHOG000058933.
    KOiK03705.
    OrthoDBiEOG632D4G.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.450.40. 1 hit.
    HAMAPiMF_00081. HrcA.
    InterProiIPR029016. GAF_dom_like.
    IPR002571. HrcA.
    IPR021153. HrcA_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01628. HrcA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005485. HrcA. 1 hit.
    SUPFAMiSSF55781. SSF55781. 1 hit.
    TIGRFAMsiTIGR00331. hrcA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P64397-1 [UniParc]FASTAAdd to Basket

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    MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP    50
    ATIRNVMSDL EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER 100
    SSIEAQVRAA GTSNSVESVL TEASQVLSGL SRGAGLVLTN KTDVALKHIE 150
    FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG ISTSQLIEAS NFLNAHIHGH 200
    TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA DQPARLIVRG 250
    RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE 300
    NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI 350
    VSRLLR 356
    Length:356
    Mass (Da):39,094
    Last modified:October 11, 2004 - v1
    Checksum:i1F72BCC0E77A2FB7
    GO

    Sequence cautioni

    The sequence AAN29125.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AEM17537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
    CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
    RefSeqiNP_697210.1. NC_004310.3.
    YP_005615029.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29125; AAN29125; BR0172.
    AEM17537; AEM17537; BS1330_I0172.
    GeneIDi1165829.
    12138713.
    KEGGibms:BR0172.
    bsi:BS1330_I0172.
    PATRICi17788612. VBIBruSui107850_0179.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29125.1 . Different initiation.
    CP002997 Genomic DNA. Translation: AEM17537.1 . Different initiation.
    RefSeqi NP_697210.1. NC_004310.3.
    YP_005615029.1. NC_017251.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29125 ; AAN29125 ; BR0172 .
    AEM17537 ; AEM17537 ; BS1330_I0172 .
    GeneIDi 1165829.
    12138713.
    KEGGi bms:BR0172.
    bsi:BS1330_I0172.
    PATRICi 17788612. VBIBruSui107850_0179.

    Phylogenomic databases

    eggNOGi COG1420.
    HOGENOMi HOG000058933.
    KOi K03705.
    OrthoDBi EOG632D4G.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.450.40. 1 hit.
    HAMAPi MF_00081. HrcA.
    InterProi IPR029016. GAF_dom_like.
    IPR002571. HrcA.
    IPR021153. HrcA_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01628. HrcA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005485. HrcA. 1 hit.
    SUPFAMi SSF55781. SSF55781. 1 hit.
    TIGRFAMsi TIGR00331. hrcA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiHRCA_BRUSU
    AccessioniPrimary (citable) accession number: P64397
    Secondary accession number(s): G0KBE5, Q8YEV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3