P64397 (HRCA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat-inducible transcription repressor HrcA

Gene names

Name:	hrcA
Ordered Locus Names:	BR0172, BS1330_I0172

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons By similarity. HAMAP-Rule MF_00081
Sequence similarities	Belongs to the HrcA family.
Sequence caution	The sequence AAN29125.1 differs from that shown. Reason: Erroneous initiation. The sequence AEM17537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Stress response Transcription Transcription regulation
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Heat-inducible transcription repressor HrcA HAMAP-Rule MF_00081		PRO_0000182459

Sequences

	Sequence		Length	Mass (Da)
	P64397 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 1F72BCC0E77A2FB7	FASTA	356	39,094
	10 20 30 40 50 60 MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP ATIRNVMSDL 70 80 90 100 110 120 EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER SSIEAQVRAA GTSNSVESVL 130 140 150 160 170 180 TEASQVLSGL SRGAGLVLTN KTDVALKHIE FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG 190 200 210 220 230 240 ISTSQLIEAS NFLNAHIHGH TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA 250 260 270 280 290 300 DQPARLIVRG RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE 310 320 330 340 350 NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI VSRLLR

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation. CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
RefSeq	NP_697210.1. NC_004310.3. YP_005615029.1. NC_017251.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BR0172.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN29125; AAN29125; BR0172. AEM17537; AEM17537; BS1330_I0172.
GeneID	1165829. 12138713.
KEGG	bms:BR0172. bsi:BS1330_I0172.
PATRIC	17788612. VBIBruSui107850_0179.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1420.
HOGENOM	HOG000058933.
KO	K03705.
ProtClustDB	PRK00082.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
HAMAP	MF_00081. HrcA.
InterPro	IPR011991. WHTH_DNA-bd_dom. IPR002571. WHTH_transcript_rep_HrcA. IPR021153. WHTH_transcript_rep_HrcA_C. [Graphical view]
Pfam	PF01628. HrcA. 1 hit. [Graphical view]
PIRSF	PIRSF005485. HrcA. 1 hit.
TIGRFAMs	TIGR00331. hrcA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HRCA_BRUSU

Accession

Primary (citable) accession number: P64397
Secondary accession number(s): G0KBE5, Q8YEV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program