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P64397

- HRCA_BRUSU

UniProt

P64397 - HRCA_BRUSU

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Protein
Heat-inducible transcription repressor HrcA
Gene
hrcA, BR0172, BS1330_I0172
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. response to stress Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-inducible transcription repressor HrcA
Gene namesi
Name:hrcA
Ordered Locus Names:BR0172, BS1330_I0172
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Heat-inducible transcription repressor HrcAUniRule annotation
PRO_0000182459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0172.

Family & Domainsi

Sequence similaritiesi

Belongs to the HrcA family.

Phylogenomic databases

eggNOGiCOG1420.
HOGENOMiHOG000058933.
KOiK03705.
OrthoDBiEOG632D4G.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPiMF_00081. HrcA.
InterProiIPR029016. GAF_dom_like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.

Sequencei

Sequence statusi: Complete.

P64397-1 [UniParc]FASTAAdd to Basket

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MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP    50
ATIRNVMSDL EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER 100
SSIEAQVRAA GTSNSVESVL TEASQVLSGL SRGAGLVLTN KTDVALKHIE 150
FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG ISTSQLIEAS NFLNAHIHGH 200
TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA DQPARLIVRG 250
RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE 300
NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI 350
VSRLLR 356
Length:356
Mass (Da):39,094
Last modified:October 11, 2004 - v1
Checksum:i1F72BCC0E77A2FB7
GO

Sequence cautioni

The sequence AAN29125.1 differs from that shown. Reason: Erroneous initiation.
The sequence AEM17537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
RefSeqiNP_697210.1. NC_004310.3.
YP_005615029.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29125; AAN29125; BR0172.
AEM17537; AEM17537; BS1330_I0172.
GeneIDi1165829.
12138713.
KEGGibms:BR0172.
bsi:BS1330_I0172.
PATRICi17788612. VBIBruSui107850_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29125.1 . Different initiation.
CP002997 Genomic DNA. Translation: AEM17537.1 . Different initiation.
RefSeqi NP_697210.1. NC_004310.3.
YP_005615029.1. NC_017251.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 204722.BR0172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29125 ; AAN29125 ; BR0172 .
AEM17537 ; AEM17537 ; BS1330_I0172 .
GeneIDi 1165829.
12138713.
KEGGi bms:BR0172.
bsi:BS1330_I0172.
PATRICi 17788612. VBIBruSui107850_0179.

Phylogenomic databases

eggNOGi COG1420.
HOGENOMi HOG000058933.
KOi K03705.
OrthoDBi EOG632D4G.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPi MF_00081. HrcA.
InterProi IPR029016. GAF_dom_like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01628. HrcA. 1 hit.
[Graphical view ]
PIRSFi PIRSF005485. HrcA. 1 hit.
SUPFAMi SSF55781. SSF55781. 1 hit.
TIGRFAMsi TIGR00331. hrcA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiHRCA_BRUSU
AccessioniPrimary (citable) accession number: P64397
Secondary accession number(s): G0KBE5, Q8YEV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi