Reviewed, UniProtKB/Swiss-Prot P64397 (HRCA_BRUSU)

Names and origin

Protein names

Recommended name:
    Heat-inducible transcription repressor hrcA

Gene names

Name:	hrcA
Ordered Locus Names:	BR0172

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons By similarity.
Sequence similarities	Belongs to the hrcA family.

Ontologies

Keywords
Biological process	Stress response Transcription Transcription regulation
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription repressor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Heat-inducible transcription repressor hrcA HAMAP MF_00081		PRO_0000182459

Sequences

	Sequence		Length	Mass (Da)
	P64397-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 1F72BCC0E77A2FB7	FASTA	356	39,094
	10 20 30 40 50 60 MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP ATIRNVMSDL 70 80 90 100 110 120 EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER SSIEAQVRAA GTSNSVESVL 130 140 150 160 170 180 TEASQVLSGL SRGAGLVLTN KTDVALKHIE FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG 190 200 210 220 230 240 ISTSQLIEAS NFLNAHIHGH TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA 250 260 270 280 290 300 DQPARLIVRG RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE 310 320 330 340 350 NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI VSRLLR

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
RefSeq	NP_697210.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1165829.
GenomeReviews	Gene locus BR0172 in contig AE014291_GR.
KEGG	bms:BR0172.
TIGR	BR0172.
Phylogenomic databases
HOGENOM	HBG729878.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0172-MON.
Family and domain databases
HAMAP	MF_00081. [Tree]
InterPro	IPR002571. HrcA. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF01628. HrcA. 1 hit. [Graphical view]
PIRSF	PIRSF005485. HrcA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HRCA_BRUSU

Accession

Primary (citable) accession number: P64397
Secondary accession number(s): Q8YEV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	December 15, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)