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P64397 (HRCA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat-inducible transcription repressor HrcA
Gene names
Name:hrcA
Ordered Locus Names:BR0172, BS1330_I0172
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons By similarity. HAMAP-Rule MF_00081

Sequence similarities

Belongs to the HrcA family.

Sequence caution

The sequence AAN29125.1 differs from that shown. Reason: Erroneous initiation.

The sequence AEM17537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Heat-inducible transcription repressor HrcA HAMAP-Rule MF_00081
PRO_0000182459

Sequences

Sequence LengthMass (Da)Tools
P64397 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1F72BCC0E77A2FB7

FASTA35639,094
        10         20         30         40         50         60 
MMRPPEHQLL SSLDQRSRDI FRLIVETYLN DGDPVGSRNL SRLLPHTLSP ATIRNVMSDL 

        70         80         90        100        110        120 
EHLGLIYAPH ISAGRLPTQI GLRFFVDAFL EVGDLPPEER SSIEAQVRAA GTSNSVESVL 

       130        140        150        160        170        180 
TEASQVLSGL SRGAGLVLTN KTDVALKHIE FVRLEPMRAL AVLVMQNGDV ENRVIDLPAG 

       190        200        210        220        230        240 
ISTSQLIEAS NFLNAHIHGH TLSEAKSELR KLSEETRREL DQLSQELVAK GLAVWSGAGA 

       250        260        270        280        290        300 
DQPARLIVRG RANLLENVHA QEDIERLRHL FDDLETKDGM VQLLDLAEAG SGVRIFIGSE 

       310        320        330        340        350 
NKLFSLSGSS LVVAPYRDSE QRVIGALGVI GPTRLNYARI VPMVDYTAQI VSRLLR 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29125.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM17537.1. Different initiation.
RefSeqNP_697210.1. NC_004310.3.
YP_005615029.1. NC_017251.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29125; AAN29125; BR0172.
AEM17537; AEM17537; BS1330_I0172.
GeneID1165829.
12138713.
KEGGbms:BR0172.
bsi:BS1330_I0172.
PATRIC17788612. VBIBruSui107850_0179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1420.
HOGENOMHOG000058933.
KOK03705.
OrthoDBEOG632D4G.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
HAMAPMF_00081. HrcA.
InterProIPR029016. GAF_dom_like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFPIRSF005485. HrcA. 1 hit.
SUPFAMSSF55781. SSF55781. 1 hit.
TIGRFAMsTIGR00331. hrcA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHRCA_BRUSU
AccessionPrimary (citable) accession number: P64397
Secondary accession number(s): G0KBE5, Q8YEV1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names