Reviewed, UniProtKB/Swiss-Prot P64352 (HIS2_BRUSU)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	BR2086

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000136353

Sequences

	Sequence		Length	Mass (Da)
	P64352-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4335A80E49ACB391	FASTA	107	11,253
	10 20 30 40 50 60 MSQFTLADLE RIVAERASVT DGTSYTASLV AKGQPKAAQK LGEEAVETVI AAVSGDRAGV 70 80 90 100 VSESADLLYH LAVVWNIAGV ALEDVLQELQ RRTAQTGLAE KASRPKG

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN30976.1.
RefSeq	NP_699061.1.
3D structure databases
SMR	P64352. Positions 6-95.
ModBase	Search...
Genome annotation databases
GeneID	1167789.
GenomeReviews	Gene locus BR2086 in contig AE014291_GR.
KEGG	bms:BR2086.
TIGR	BR2086.
Phylogenomic databases
HOGENOM	HBG646527.
OMA	ETVMAAK.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_2086-MONOMER.
BRENDA	3.6.1.31. 281610.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. IPR021130. PRib-ATP_pyroPHydrolase-like. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_BRUSU

Accession

Primary (citable) accession number: P64352
Secondary accession number(s): Q8YE38

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)