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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:NMA1768
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519181 – 217ATP phosphoribosyltransferaseAdd BLAST217

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliP64346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223248.
KOiK00765.
OMAiNPVSYRM.

Family and domain databases

CDDicd13595. PBP2_HisGs. 1 hit.
HAMAPiMF_01018. HisG_Short. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PTHR21403:SF3. PTHR21403:SF3. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDNALTIAL SKGRIFEETL PLLAAAGIVP TEEPEKSRKL IIGTNHENIR
60 70 80 90 100
LVIVRATDVP TYVRYGAADF GIAGKDVLIE HGGTGLYRPL DLEIAKCRMM
110 120 130 140 150
VAVRKGFDYE AASQPGCRLK IATKYPEIAA SHFAGKGVHV DIIKLYGSME
160 170 180 190 200
LAPLVGLSDA IVDLVSTGNT LKANGLEAVE HIVDISSRLV VNKAALKTKY
210
ALLEPIIQAF GGAVKAK
Length:217
Mass (Da):23,263
Last modified:October 11, 2004 - v1
Checksum:iD7492BCF038E54B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08895.1.
RefSeqiWP_002261539.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08895; CAM08895; NMA1768.
KEGGinma:NMA1768.
PATRICi20364832. VBINeiMen132687_2118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157959 Genomic DNA. Translation: CAM08895.1.
RefSeqiWP_002261539.1. NC_003116.1.

3D structure databases

ProteinModelPortaliP64346.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM08895; CAM08895; NMA1768.
KEGGinma:NMA1768.
PATRICi20364832. VBINeiMen132687_2118.

Phylogenomic databases

HOGENOMiHOG000223248.
KOiK00765.
OMAiNPVSYRM.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Family and domain databases

CDDicd13595. PBP2_HisGs. 1 hit.
HAMAPiMF_01018. HisG_Short. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PTHR21403:SF3. PTHR21403:SF3. 1 hit.
PfamiPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00070. hisG. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIS1_NEIMA
AccessioniPrimary (citable) accession number: P64346
Secondary accession number(s): A1ISY3, Q9JQS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.