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P64336 (HEM3_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase
Short name=PBG
EC=2.5.1.61
Alternative name(s):
Hydroxymethylbilane synthase
Short name=HMBS
Pre-uroporphyrinogen synthase
Gene names
Name:hemC
Ordered Locus Names:Rv0510, MT0531
ORF Names:MTCY20G9.37
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. HAMAP MF_00260

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP MF_00260

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP MF_00260

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. HAMAP MF_00260

Subunit structure

Monomer By similarity. HAMAP MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethan group. HAMAP MF_00260

Sequence similarities

Belongs to the HMBS family.

Sequence caution

The sequence AAK44754.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Porphobilinogen deaminase HAMAP MF_00260
PRO_0000142960

Amino acid modifications

Modified residue2341S-(dipyrrolylmethanemethyl)cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P64336 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 047A5B123F1691F7

FASTA30931,938
        10         20         30         40         50         60 
MIRIGTRGSL LATTQAATVR DALIAGGHSA ELVTISTEGD RSMAPIASLG VGVFTTALRE 

        70         80         90        100        110        120 
AMEAGLVDAA VHSYKDLPTA ADPRFTVAAI PPRNDPRDAV VARDGLTLGE LPVGSLVGTS 

       130        140        150        160        170        180 
SPRRAAQLRA LGLGLEIRPL RGNLDTRLNK VSSGDLDAIV VARAGLARLG RLDDVTETLE 

       190        200        210        220        230        240 
PVQMLPAPAQ GALAVECRAG DSRLVAVLAE LDDADTRAAV TAERALLADL EAGCSAPVGA 

       250        260        270        280        290        300 
IAEVVESIDE DGRVFEELSL RGCVAALDGS DVIRASGIGS CGRARELGLS VAAELFELGA 


RELMWGVRH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842573 Genomic DNA. Translation: CAB00957.1.
AE000516 Genomic DNA. Translation: AAK44754.1. Different initiation.
PIRA70747.
RefSeqNP_215024.1. NC_000962.2.
NP_334940.1. NC_002755.2.

3D structure databases

ProteinModelPortalP64336.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000916; EBMYCP00000000916; EBMYCG00000000916.
EBMYCT00000072383; EBMYCP00000070442; EBMYCG00000072378.
GeneID887306.
924164.
GenomeReviewsGene locus MT0531 in contig AE000516_GR.
Gene locus Rv0510 in contig AL123456_GR.
KEGGmtc:MT0531.
mtu:Rv0510.
PATRIC18122878. VBIMycTub22151_0573.
TIGRMT0531.

Organism-specific databases

TubercuListRv0510.

Phylogenomic databases

GeneTreeEBGT00050000016689.
HOGENOMHBG624842.
OMAFKDVRGN.
PhylomeDBP64336.
ProtClustDBPRK00072.

Family and domain databases

HAMAPMF_00260. Porphobil_deam.
[Tree]
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
Gene3DG3DSA:3.30.160.40. Porphobil_deam. 1 hit.
KOK01749.
PANTHERPTHR11557. Porphobil_deam. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. Porphobil_deam. 1 hit.
TIGRFAMsTIGR00212. HemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM3_MYCTU
AccessionPrimary (citable) accession number: P64336
Secondary accession number(s): Q11173
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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