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P64306

- NTPA_BRUSU

UniProt

P64306 - NTPA_BRUSU

Protein

Non-canonical purine NTP pyrophosphatase

Gene

BR0175

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451Magnesium or manganeseUniRule annotation
    Metal bindingi74 – 741Magnesium or manganeseUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation
    Binding sitei200 – 2001SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Short name:
    NTPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:BR0175, BS1330_I0175
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Non-canonical purine NTP pyrophosphatasePRO_0000178142Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0175.

    Structurei

    3D structure databases

    ProteinModelPortaliP64306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni13 – 186Substrate bindingUniRule annotation
    Regioni74 – 752Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiRQAKFVS.
    OrthoDBiEOG65QWHX.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.
    TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P64306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMLEKGKLI VASHNAGKLR EFDGLIGPFG FEVSSVAALG LPEPDETGTT    50
    FEENAYIKAL AAAKATGFPA LSDDSGLMVD ALDGEPGVYT ANWAETEDGK 100
    RDFDMAMQKV ENLLQEKGAT TPDKRKARFV SVICLAWPDG EAEYFRGEVE 150
    GTLVWPPRGN IGFGYDPVFL PDGYGKTFGE MTAEEKHGWK PGDASALSHR 200
    ARAFKLFAEK ALNVVSAPAE 220
    Length:220
    Mass (Da):23,795
    Last modified:October 11, 2004 - v1
    Checksum:i0055354117112336
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29128.1.
    CP002997 Genomic DNA. Translation: AEM17540.1.
    RefSeqiNP_697213.1. NC_004310.3.
    YP_005615032.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29128; AAN29128; BR0175.
    AEM17540; AEM17540; BS1330_I0175.
    GeneIDi1165832.
    12138716.
    KEGGibms:BR0175.
    bsi:BS1330_I0175.
    PATRICi17788620. VBIBruSui107850_0183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29128.1 .
    CP002997 Genomic DNA. Translation: AEM17540.1 .
    RefSeqi NP_697213.1. NC_004310.3.
    YP_005615032.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali P64306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29128 ; AAN29128 ; BR0175 .
    AEM17540 ; AEM17540 ; BS1330_I0175 .
    GeneIDi 1165832.
    12138716.
    KEGGi bms:BR0175.
    bsi:BS1330_I0175.
    PATRICi 17788620. VBIBruSui107850_0183.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi RQAKFVS.
    OrthoDBi EOG65QWHX.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiNTPA_BRUSU
    AccessioniPrimary (citable) accession number: P64306
    Secondary accession number(s): G0KBE8, Q8YEV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3