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P64306

- NTPA_BRUSU

UniProt

P64306 - NTPA_BRUSU

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Protein

Non-canonical purine NTP pyrophosphatase

Gene

BR0175

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Magnesium or manganeseUniRule annotation
Metal bindingi74 – 741Magnesium or manganeseUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:BR0175, BS1330_I0175
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Non-canonical purine NTP pyrophosphatasePRO_0000178142Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0175.

Structurei

3D structure databases

ProteinModelPortaliP64306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 186Substrate bindingUniRule annotation
Regioni74 – 752Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiRQAKFVS.
OrthoDBiEOG65QWHX.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

P64306 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRMLEKGKLI VASHNAGKLR EFDGLIGPFG FEVSSVAALG LPEPDETGTT
60 70 80 90 100
FEENAYIKAL AAAKATGFPA LSDDSGLMVD ALDGEPGVYT ANWAETEDGK
110 120 130 140 150
RDFDMAMQKV ENLLQEKGAT TPDKRKARFV SVICLAWPDG EAEYFRGEVE
160 170 180 190 200
GTLVWPPRGN IGFGYDPVFL PDGYGKTFGE MTAEEKHGWK PGDASALSHR
210 220
ARAFKLFAEK ALNVVSAPAE
Length:220
Mass (Da):23,795
Last modified:October 11, 2004 - v1
Checksum:i0055354117112336
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29128.1.
CP002997 Genomic DNA. Translation: AEM17540.1.
RefSeqiNP_697213.1. NC_004310.3.
YP_005615032.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29128; AAN29128; BR0175.
AEM17540; AEM17540; BS1330_I0175.
GeneIDi1165832.
12138716.
KEGGibms:BR0175.
bsi:BS1330_I0175.
PATRICi17788620. VBIBruSui107850_0183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29128.1 .
CP002997 Genomic DNA. Translation: AEM17540.1 .
RefSeqi NP_697213.1. NC_004310.3.
YP_005615032.1. NC_017251.1.

3D structure databases

ProteinModelPortali P64306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29128 ; AAN29128 ; BR0175 .
AEM17540 ; AEM17540 ; BS1330_I0175 .
GeneIDi 1165832.
12138716.
KEGGi bms:BR0175.
bsi:BS1330_I0175.
PATRICi 17788620. VBIBruSui107850_0183.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi RQAKFVS.
OrthoDBi EOG65QWHX.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiNTPA_BRUSU
AccessioniPrimary (citable) accession number: P64306
Secondary accession number(s): G0KBE8, Q8YEV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3