SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P64306

- NTPA_BRUSU

UniProt

P64306 - NTPA_BRUSU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Non-canonical purine NTP pyrophosphatase
Gene
BR0175, BS1330_I0175
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Magnesium or manganese By similarity
Metal bindingi74 – 741Magnesium or manganese By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei200 – 2001Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphatase (EC:3.6.1.19)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:BR0175, BS1330_I0175
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Non-canonical purine NTP pyrophosphataseUniRule annotation
PRO_0000178142Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0175.

Structurei

3D structure databases

ProteinModelPortaliP64306.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 186Substrate binding By similarity
Regioni74 – 752Substrate binding By similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiRQAKFVS.
OrthoDBiEOG65QWHX.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

P64306-1 [UniParc]FASTAAdd to Basket

« Hide

MRMLEKGKLI VASHNAGKLR EFDGLIGPFG FEVSSVAALG LPEPDETGTT    50
FEENAYIKAL AAAKATGFPA LSDDSGLMVD ALDGEPGVYT ANWAETEDGK 100
RDFDMAMQKV ENLLQEKGAT TPDKRKARFV SVICLAWPDG EAEYFRGEVE 150
GTLVWPPRGN IGFGYDPVFL PDGYGKTFGE MTAEEKHGWK PGDASALSHR 200
ARAFKLFAEK ALNVVSAPAE 220
Length:220
Mass (Da):23,795
Last modified:October 11, 2004 - v1
Checksum:i0055354117112336
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29128.1.
CP002997 Genomic DNA. Translation: AEM17540.1.
RefSeqiNP_697213.1. NC_004310.3.
YP_005615032.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29128; AAN29128; BR0175.
AEM17540; AEM17540; BS1330_I0175.
GeneIDi1165832.
12138716.
KEGGibms:BR0175.
bsi:BS1330_I0175.
PATRICi17788620. VBIBruSui107850_0183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29128.1 .
CP002997 Genomic DNA. Translation: AEM17540.1 .
RefSeqi NP_697213.1. NC_004310.3.
YP_005615032.1. NC_017251.1.

3D structure databases

ProteinModelPortali P64306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29128 ; AAN29128 ; BR0175 .
AEM17540 ; AEM17540 ; BS1330_I0175 .
GeneIDi 1165832.
12138716.
KEGGi bms:BR0175.
bsi:BS1330_I0175.
PATRICi 17788620. VBIBruSui107850_0183.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi RQAKFVS.
OrthoDBi EOG65QWHX.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiNTPA_BRUSU
AccessioniPrimary (citable) accession number: P64306
Secondary accession number(s): G0KBE8, Q8YEV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi