Reviewed, UniProtKB/Swiss-Prot P64305 (NTPA_BRUME)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BMEI1772

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178141

Sequences

	Sequence		Length	Mass (Da)
	P64305-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 0055354117112336	FASTA	220	23,795
	10 20 30 40 50 60 MRMLEKGKLI VASHNAGKLR EFDGLIGPFG FEVSSVAALG LPEPDETGTT FEENAYIKAL 70 80 90 100 110 120 AAAKATGFPA LSDDSGLMVD ALDGEPGVYT ANWAETEDGK RDFDMAMQKV ENLLQEKGAT 130 140 150 160 170 180 TPDKRKARFV SVICLAWPDG EAEYFRGEVE GTLVWPPRGN IGFGYDPVFL PDGYGKTFGE 190 200 210 220 MTAEEKHGWK PGDASALSHR ARAFKLFAEK ALNVVSAPAE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009610 Genomic DNA. Translation: AAL52953.1. Different initiation.
PIR	AF3473.
RefSeq	NP_540689.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	1197483.
GenomeReviews	Gene locus BMEI1772 in contig AE008917_GR.
KEGG	bme:BMEI1772.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P64305.
OMA	P64305. VYTADWA.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI1772-MON.
BRENDA	3.6.1.15. 277959.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BRUME

Accession

Primary (citable) accession number: P64305
Secondary accession number(s): Q8YEV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)