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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:SAV1610
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Transcription elongation factor GreAPRO_0000176971Add
BLAST

Proteomic databases

PaxDbiP64283.

2D gel databases

World-2DPAGE0002:P64283.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1610.

Structurei

3D structure databases

ProteinModelPortaliP64283.
SMRiP64283. Positions 8-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 7067UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4108UKH. Bacteria.
COG0782. LUCA.
HOGENOMiHOG000241145.
KOiK03624.
OMAiHNEGRIA.
OrthoDBiEOG686NQ9.
PhylomeDBiP64283.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQKQYPMT QEGFEKLERE LEELKTVKRP EVVEKIKVAR SFGDLSENSE
60 70 80 90 100
YDAAKDEQGF IEQDIQRIEH MLRNALIIED TGDNNVVKIG KTVTFVELPG
110 120 130 140 150
DEEESYQIVG SAESDAFNGK ISNESPMAKA LIGKGLDDEV RVPLPNGGEM

NVKIVNIQ
Length:158
Mass (Da):17,743
Last modified:October 11, 2004 - v1
Checksum:iEC3B0F0E6238A107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57772.1.
RefSeqiWP_000431312.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57772; BAB57772; SAV1610.
KEGGisav:SAV1610.
PATRICi19563964. VBIStaAur52173_1660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57772.1.
RefSeqiWP_000431312.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP64283.
SMRiP64283. Positions 8-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1610.

2D gel databases

World-2DPAGE0002:P64283.

Proteomic databases

PaxDbiP64283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB57772; BAB57772; SAV1610.
KEGGisav:SAV1610.
PATRICi19563964. VBIStaAur52173_1660.

Phylogenomic databases

eggNOGiENOG4108UKH. Bacteria.
COG0782. LUCA.
HOGENOMiHOG000241145.
KOiK03624.
OMAiHNEGRIA.
OrthoDBiEOG686NQ9.
PhylomeDBiP64283.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1625-MONOMER.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiGREA_STAAM
AccessioniPrimary (citable) accession number: P64283
Secondary accession number(s): Q99TN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.