Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription elongation factor GreA

Gene

greA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:SAV1610
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001769711 – 158Transcription elongation factor GreAAdd BLAST158

Proteomic databases

PaxDbiP64283
PRIDEiP64283

2D gel databases

World-2DPAGEi0002:P64283

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi158878.SAV1610

Structurei

3D structure databases

ProteinModelPortaliP64283
SMRiP64283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 70UniRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4108UKH Bacteria
COG0782 LUCA
HOGENOMiHOG000241145
KOiK03624
OMAiTWLTQEA
PhylomeDBiP64283

Family and domain databases

Gene3Di1.10.287.180, 1 hit
3.10.50.30, 1 hit
HAMAPiMF_00105 GreA_GreB, 1 hit
InterProiView protein in InterPro
IPR036953 GreA/GreB_C_sf
IPR018151 TF_GreA/GreB_CS
IPR006359 Tscrpt_elong_fac_GreA
IPR028624 Tscrpt_elong_fac_GreA/B
IPR001437 Tscrpt_elong_fac_GreA/B_C
IPR023459 Tscrpt_elong_fac_GreA/B_fam
IPR022691 Tscrpt_elong_fac_GreA/B_N
IPR036805 Tscrpt_elong_fac_GreA/B_N_sf
PANTHERiPTHR30437 PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272 GreA_GreB, 1 hit
PF03449 GreA_GreB_N, 1 hit
PIRSFiPIRSF006092 GreA_GreB, 1 hit
SUPFAMiSSF46557 SSF46557, 1 hit
TIGRFAMsiTIGR01462 greA, 1 hit
PROSITEiView protein in PROSITE
PS00829 GREAB_1, 1 hit
PS00830 GREAB_2, 1 hit

Sequencei

Sequence statusi: Complete.

P64283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQKQYPMT QEGFEKLERE LEELKTVKRP EVVEKIKVAR SFGDLSENSE
60 70 80 90 100
YDAAKDEQGF IEQDIQRIEH MLRNALIIED TGDNNVVKIG KTVTFVELPG
110 120 130 140 150
DEEESYQIVG SAESDAFNGK ISNESPMAKA LIGKGLDDEV RVPLPNGGEM

NVKIVNIQ
Length:158
Mass (Da):17,743
Last modified:October 11, 2004 - v1
Checksum:iEC3B0F0E6238A107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57772.1
RefSeqiWP_000431312.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57772; BAB57772; SAV1610
KEGGisav:SAV1610

Similar proteinsi

Entry informationi

Entry nameiGREA_STAAM
AccessioniPrimary (citable) accession number: P64283
Secondary accession number(s): Q99TN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health