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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciHPY:HP0866-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:HP_0866
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001769311 – 164Transcription elongation factor GreAAdd BLAST164

Proteomic databases

PaxDbiP64275

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi85962.HP0866

Structurei

3D structure databases

ProteinModelPortaliP64275
SMRiP64275
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UKH Bacteria
COG0782 LUCA
KOiK03624
OMAiTWLTQEA

Family and domain databases

Gene3Di1.10.287.180, 1 hit
3.10.50.30, 1 hit
HAMAPiMF_00105 GreA_GreB, 1 hit
InterProiView protein in InterPro
IPR036953 GreA/GreB_C_sf
IPR018151 TF_GreA/GreB_CS
IPR006359 Tscrpt_elong_fac_GreA
IPR028624 Tscrpt_elong_fac_GreA/B
IPR001437 Tscrpt_elong_fac_GreA/B_C
IPR023459 Tscrpt_elong_fac_GreA/B_fam
IPR022691 Tscrpt_elong_fac_GreA/B_N
IPR036805 Tscrpt_elong_fac_GreA/B_N_sf
PANTHERiPTHR30437 PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272 GreA_GreB, 1 hit
PF03449 GreA_GreB_N, 1 hit
PIRSFiPIRSF006092 GreA_GreB, 1 hit
SUPFAMiSSF46557 SSF46557, 1 hit
TIGRFAMsiTIGR01462 greA, 1 hit
PROSITEiView protein in PROSITE
PS00829 GREAB_1, 1 hit
PS00830 GREAB_2, 1 hit

Sequencei

Sequence statusi: Complete.

P64275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEPMSMHG YNKICAELKQ LKEVERPNIV KEIDIARGHG DLKENAEYHA
60 70 80 90 100
AKEKQRFIEA RIVDLSEIVA NAQVIDPSAL AHNKVSFGST IKILNLDNDK
110 120 130 140 150
EFSYTIVGSV ESDPAKGLIS FGSPIAKSLI GKSKGDAVSI QLPNGESDFE
160
ILDIYYKEIC FDEN
Length:164
Mass (Da):18,199
Last modified:October 11, 2004 - v1
Checksum:i439E43A5FD0965BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07908.1
PIRiB64628
RefSeqiNP_207660.1, NC_000915.1
WP_001031337.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07908; AAD07908; HP_0866
GeneIDi899395
KEGGiheo:C694_04435
hpy:HP0866
PATRICifig|85962.47.peg.920

Similar proteinsi

Entry informationi

Entry nameiGREA_HELPY
AccessioniPrimary (citable) accession number: P64275
Secondary accession number(s): P55978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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