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P64275

- GREA_HELPY

UniProt

P64275 - GREA_HELPY

Protein

Transcription elongation factor GreA

Gene

greA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of DNA-templated transcription, elongation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0866-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor GreAUniRule annotation
    Alternative name(s):
    Transcript cleavage factor GreAUniRule annotation
    Gene namesi
    Name:greAUniRule annotation
    Ordered Locus Names:HP_0866
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Transcription elongation factor GreAPRO_0000176931Add
    BLAST

    Proteomic databases

    PRIDEiP64275.

    Interactioni

    Protein-protein interaction databases

    STRINGi85962.HP0866.

    Structurei

    3D structure databases

    ProteinModelPortaliP64275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GreA/GreB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0782.
    KOiK03624.
    OMAiITKVEWR.
    OrthoDBiEOG686NQ9.

    Family and domain databases

    Gene3Di1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPiMF_00105. GreA_GreB.
    InterProiIPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view]
    PfamiPF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006092. GreA_GreB. 1 hit.
    SUPFAMiSSF46557. SSF46557. 1 hit.
    TIGRFAMsiTIGR01462. greA. 1 hit.
    PROSITEiPS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P64275-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKEPMSMHG YNKICAELKQ LKEVERPNIV KEIDIARGHG DLKENAEYHA    50
    AKEKQRFIEA RIVDLSEIVA NAQVIDPSAL AHNKVSFGST IKILNLDNDK 100
    EFSYTIVGSV ESDPAKGLIS FGSPIAKSLI GKSKGDAVSI QLPNGESDFE 150
    ILDIYYKEIC FDEN 164
    Length:164
    Mass (Da):18,199
    Last modified:October 11, 2004 - v1
    Checksum:i439E43A5FD0965BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07908.1.
    PIRiB64628.
    RefSeqiNP_207660.1. NC_000915.1.
    YP_006934780.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07908; AAD07908; HP_0866.
    GeneIDi13870050.
    899395.
    KEGGiheo:C694_04435.
    hpy:HP0866.
    PATRICi20593021. VBIHelPyl33062_0898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07908.1 .
    PIRi B64628.
    RefSeqi NP_207660.1. NC_000915.1.
    YP_006934780.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P64275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0866.

    Proteomic databases

    PRIDEi P64275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07908 ; AAD07908 ; HP_0866 .
    GeneIDi 13870050.
    899395.
    KEGGi heo:C694_04435.
    hpy:HP0866.
    PATRICi 20593021. VBIHelPyl33062_0898.

    Phylogenomic databases

    eggNOGi COG0782.
    KOi K03624.
    OMAi ITKVEWR.
    OrthoDBi EOG686NQ9.

    Enzyme and pathway databases

    BioCyci HPY:HP0866-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPi MF_00105. GreA_GreB.
    InterProi IPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view ]
    Pfami PF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006092. GreA_GreB. 1 hit.
    SUPFAMi SSF46557. SSF46557. 1 hit.
    TIGRFAMsi TIGR01462. greA. 1 hit.
    PROSITEi PS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiGREA_HELPY
    AccessioniPrimary (citable) accession number: P64275
    Secondary accession number(s): P55978
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3