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P64275

- GREA_HELPY

UniProt

P64275 - GREA_HELPY

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Protein
Transcription elongation factor GreA
Gene
greA, HP_0866
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of DNA-templated transcription, elongation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0866-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreA
Alternative name(s):
Transcript cleavage factor GreA
Gene namesi
Name:greA
Ordered Locus Names:HP_0866
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Transcription elongation factor GreAUniRule annotation
PRO_0000176931Add
BLAST

Proteomic databases

PRIDEiP64275.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0866.

Structurei

3D structure databases

ProteinModelPortaliP64275.

Family & Domainsi

Sequence similaritiesi

Belongs to the GreA/GreB family.

Phylogenomic databases

eggNOGiCOG0782.
KOiK03624.
OMAiITKVEWR.
OrthoDBiEOG686NQ9.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64275-1 [UniParc]FASTAAdd to Basket

« Hide

MNKEPMSMHG YNKICAELKQ LKEVERPNIV KEIDIARGHG DLKENAEYHA    50
AKEKQRFIEA RIVDLSEIVA NAQVIDPSAL AHNKVSFGST IKILNLDNDK 100
EFSYTIVGSV ESDPAKGLIS FGSPIAKSLI GKSKGDAVSI QLPNGESDFE 150
ILDIYYKEIC FDEN 164
Length:164
Mass (Da):18,199
Last modified:October 11, 2004 - v1
Checksum:i439E43A5FD0965BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07908.1.
PIRiB64628.
RefSeqiNP_207660.1. NC_000915.1.
YP_006934780.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07908; AAD07908; HP_0866.
GeneIDi13870050.
899395.
KEGGiheo:C694_04435.
hpy:HP0866.
PATRICi20593021. VBIHelPyl33062_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07908.1 .
PIRi B64628.
RefSeqi NP_207660.1. NC_000915.1.
YP_006934780.1. NC_018939.1.

3D structure databases

ProteinModelPortali P64275.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85962.HP0866.

Proteomic databases

PRIDEi P64275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07908 ; AAD07908 ; HP_0866 .
GeneIDi 13870050.
899395.
KEGGi heo:C694_04435.
hpy:HP0866.
PATRICi 20593021. VBIHelPyl33062_0898.

Phylogenomic databases

eggNOGi COG0782.
KOi K03624.
OMAi ITKVEWR.
OrthoDBi EOG686NQ9.

Enzyme and pathway databases

BioCyci HPY:HP0866-MONOMER.

Family and domain databases

Gene3Di 1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPi MF_00105. GreA_GreB.
InterProi IPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view ]
Pfami PF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF006092. GreA_GreB. 1 hit.
SUPFAMi SSF46557. SSF46557. 1 hit.
TIGRFAMsi TIGR01462. greA. 1 hit.
PROSITEi PS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGREA_HELPY
AccessioniPrimary (citable) accession number: P64275
Secondary accession number(s): P55978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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