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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0866-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:HP_0866
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Transcription elongation factor GreAPRO_0000176931Add
BLAST

Proteomic databases

PRIDEiP64275.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP0866.

Structurei

3D structure databases

ProteinModelPortaliP64275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0782.
KOiK03624.
OMAiHNEGRIA.
OrthoDBiEOG686NQ9.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEPMSMHG YNKICAELKQ LKEVERPNIV KEIDIARGHG DLKENAEYHA
60 70 80 90 100
AKEKQRFIEA RIVDLSEIVA NAQVIDPSAL AHNKVSFGST IKILNLDNDK
110 120 130 140 150
EFSYTIVGSV ESDPAKGLIS FGSPIAKSLI GKSKGDAVSI QLPNGESDFE
160
ILDIYYKEIC FDEN
Length:164
Mass (Da):18,199
Last modified:October 11, 2004 - v1
Checksum:i439E43A5FD0965BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07908.1.
PIRiB64628.
RefSeqiNP_207660.1. NC_000915.1.
WP_001031337.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07908; AAD07908; HP_0866.
GeneIDi899395.
KEGGiheo:C694_04435.
hpy:HP0866.
PATRICi20593021. VBIHelPyl33062_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07908.1.
PIRiB64628.
RefSeqiNP_207660.1. NC_000915.1.
WP_001031337.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP64275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0866.

Proteomic databases

PRIDEiP64275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07908; AAD07908; HP_0866.
GeneIDi899395.
KEGGiheo:C694_04435.
hpy:HP0866.
PATRICi20593021. VBIHelPyl33062_0898.

Phylogenomic databases

eggNOGiCOG0782.
KOiK03624.
OMAiHNEGRIA.
OrthoDBiEOG686NQ9.

Enzyme and pathway databases

BioCyciHPY:HP0866-MONOMER.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGREA_HELPY
AccessioniPrimary (citable) accession number: P64275
Secondary accession number(s): P55978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.