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P64271 (GREA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription elongation factor GreA
Alternative name(s):
Transcript cleavage factor GreA
Gene names
Name:greA
Ordered Locus Names:BMEI0508
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides By similarity. HAMAP-Rule MF_00105

Sequence similarities

Belongs to the GreA/GreB family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of DNA-templated transcription, elongation

Inferred from electronic annotation. Source: InterPro

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Transcription elongation factor GreA HAMAP-Rule MF_00105
PRO_0000176910

Sequences

Sequence LengthMass (Da)Tools
P64271 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5651BAFED6942B3F

FASTA15717,529
        10         20         30         40         50         60 
MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA AKEAQSLNEG 

        70         80         90        100        110        120 
RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE EKIYQIVGDQ EADVKEGRIS 

       130        140        150 
ISSPIARALI GKGEGDTIEV NAPGGSRSYE IIALKFV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL51689.1.
PIRAF3315.
RefSeqNP_539425.1. NC_003317.1.

3D structure databases

ProteinModelPortalP64271.
SMRP64271. Positions 2-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0508.

Proteomic databases

PRIDEP64271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL51689; AAL51689; BMEI0508.
GeneID1196219.
KEGGbme:BMEI0508.
PATRIC17801119. VBIBruMel146950_2885.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000241145.
KOK03624.
OMAHNEGRIA.
OrthoDBEOG686NQ9.
ProtClustDBPRK00226.

Family and domain databases

Gene3D1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPMF_00105. GreA_GreB.
InterProIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFPIRSF006092. GreA_GreB. 1 hit.
SUPFAMSSF46557. SSF46557. 1 hit.
TIGRFAMsTIGR01462. greA. 1 hit.
PROSITEPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGREA_BRUME
AccessionPrimary (citable) accession number: P64271
Secondary accession number(s): Q8YID6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names