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P64271

- GREA_BRUME

UniProt

P64271 - GREA_BRUME

Protein

Transcription elongation factor GreA

Gene

greA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of DNA-templated transcription, elongation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor GreAUniRule annotation
    Alternative name(s):
    Transcript cleavage factor GreAUniRule annotation
    Gene namesi
    Name:greAUniRule annotation
    Ordered Locus Names:BMEI0508
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Transcription elongation factor GreAPRO_0000176910Add
    BLAST

    Proteomic databases

    PRIDEiP64271.

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI0508.

    Structurei

    3D structure databases

    ProteinModelPortaliP64271.
    SMRiP64271. Positions 2-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GreA/GreB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000241145.
    KOiK03624.
    OMAiITKVEWR.
    OrthoDBiEOG686NQ9.

    Family and domain databases

    Gene3Di1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPiMF_00105. GreA_GreB.
    InterProiIPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view]
    PfamiPF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006092. GreA_GreB. 1 hit.
    SUPFAMiSSF46557. SSF46557. 1 hit.
    TIGRFAMsiTIGR01462. greA. 1 hit.
    PROSITEiPS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P64271-1 [UniParc]FASTAAdd to Basket

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    MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA    50
    AKEAQSLNEG RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE 100
    EKIYQIVGDQ EADVKEGRIS ISSPIARALI GKGEGDTIEV NAPGGSRSYE 150
    IIALKFV 157
    Length:157
    Mass (Da):17,529
    Last modified:October 11, 2004 - v1
    Checksum:i5651BAFED6942B3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51689.1.
    PIRiAF3315.
    RefSeqiNP_539425.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51689; AAL51689; BMEI0508.
    GeneIDi1196219.
    KEGGibme:BMEI0508.
    PATRICi17801119. VBIBruMel146950_2885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51689.1 .
    PIRi AF3315.
    RefSeqi NP_539425.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali P64271.
    SMRi P64271. Positions 2-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0508.

    Proteomic databases

    PRIDEi P64271.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51689 ; AAL51689 ; BMEI0508 .
    GeneIDi 1196219.
    KEGGi bme:BMEI0508.
    PATRICi 17801119. VBIBruMel146950_2885.

    Phylogenomic databases

    HOGENOMi HOG000241145.
    KOi K03624.
    OMAi ITKVEWR.
    OrthoDBi EOG686NQ9.

    Family and domain databases

    Gene3Di 1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPi MF_00105. GreA_GreB.
    InterProi IPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view ]
    Pfami PF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006092. GreA_GreB. 1 hit.
    SUPFAMi SSF46557. SSF46557. 1 hit.
    TIGRFAMsi TIGR01462. greA. 1 hit.
    PROSITEi PS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiGREA_BRUME
    AccessioniPrimary (citable) accession number: P64271
    Secondary accession number(s): Q8YID6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3