P64265 (Y2212_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv2212/MT2268

Gene names

Ordered Locus Names:	Rv2212, MT2268
ORF Names:	MTCY190.23

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain.
Sequence caution	The sequence AAK46554.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP catabolic process Inferred from direct assay. Source: MTBBASE intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	adenylate cyclase activity Inferred from direct assay. Source: MTBBASE fatty acid binding Inferred from direct assay. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Uncharacterized protein Rv2212/MT2268		PRO_0000074132
Regions
	Domain	208 – 317	110	Guanylate cyclase

Sequences

	Sequence		Length	Mass (Da)
	P64265 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: AF26A9CFC13C91DC	FASTA	378	39,775
	10 20 30 40 50 60 MYDSLDFDAL EAAGIANPRE RAGLLTYLDE LGFTVEEMVQ AERRGRLFGL AGDVLLWSGP 70 80 90 100 110 120 PIYTLATAAD ELGLSADDVA RAWSLLGLTV AGPDVPTLSQ ADVDALATWV ALKALVGEDG 130 140 150 160 170 180 AFGLLRVLGT AMARLAEAES TMIRAGSPNI QMTHTHDELA TARAYRAAAE FVPRIGALID 190 200 210 220 230 240 TVHRHHLASA RTYFEGVIGD TSASVTCGIG FADLSSFTAL TQALTPAQLQ DLLTEFDAAV 250 260 270 280 290 300 TDVVHADGGR LVKFIGDAVM WVSSSPERLV RAAVDLVDHP GARAAELQVR AGLAYGTVLA 310 320 330 340 350 360 LNGDYFGNPV NLAARLVAAA APGQILAAAQ LRDMLPDWPA LAHGPLTLKG FDAPVMAFEL 370 HDNPRARDAD TPSPAASD

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842579 Genomic DNA. Translation: CAA94255.1. AE000516 Genomic DNA. Translation: AAK46554.1. Different initiation.
PIR	E70786.
RefSeq	NP_216728.1. NC_000962.2. NP_336740.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P64265.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002338; EBMYCP00000002338; EBMYCG00000002336. EBMYCT00000070730; EBMYCP00000068789; EBMYCG00000070725.
GeneID	887979. 924157.
GenomeReviews	Gene locus MT2268 in contig AE000516_GR. Gene locus Rv2212 in contig AL123456_GR.
KEGG	mtc:MT2268. mtu:Rv2212.
PATRIC	18126738. VBIMycTub22151_2481.
TIGR	MT2268.
Organism-specific databases
TubercuList	Rv2212.
Phylogenomic databases
GeneTree	EBGT00050000014811.
HOGENOM	HBG565223.
OMA	FGTTVNL.
ProtClustDB	CLSK791701.
Enzyme and pathway databases
BRENDA	4.6.1.1. 3445.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit.
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y2212_MYCTU

Accession

Primary (citable) accession number: P64265
Secondary accession number(s): Q10400

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program