P64254 (GLK_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	NMB1390

Organism

Neisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]

Taxonomic identifier

122586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup B

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Glucokinase HAMAP-Rule MF_00524		PRO_0000215131
Regions
	Nucleotide binding	16 – 21	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P64254 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: A7B4AA6BD6C92F0C	FASTA	328	34,951
	10 20 30 40 50 60 MSSTPNKQAG YPRLVADIGG TNARFALETA PRVIEKAAVL PCKDYDTVTD AVRAYLNQSG 70 80 90 100 110 120 ATAVRHAAFA IANPILGDWV QMTNHHWAFS IETTRQTLGL DTLILLNDFT AQALAVTQTS 130 140 150 160 170 180 SKDLMQVGGQ KPVEFAPKAV IGPGTGLGVS GLVHSHAGWV ALAGEGGHTS FPPFDDMEVL 190 200 210 220 230 240 IWQYAKNKYG HVSAERFLSG AGLSLVYEAL AAKQKAKPAK LMPSEITEKA LSGASPLCRQ 250 260 270 280 290 300 TLDIFCAMLG TVASNLALTL GARGGVYLCG GIIPRVLEYF KTSPFRSRFE NKGRFEAYLA 310 320 AIPVYVVLSE FPGISGAAAA LDNHLRNV

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41754.1.
PIR	E81089.
RefSeq	NP_274404.1. NC_003112.2.
3D structure databases
ProteinModelPortal	P64254.
ModBase	Search...
Protein-protein interaction databases
STRING	122586.NMB1390.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF41754; AAF41754; NMB1390.
GeneID	903812.
KEGG	nme:NMB1390.
PATRIC	20358463. VBINeiMen85645_1743.
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	FADKGCM.
ProtClustDB	PRK00292.
Enzyme and pathway databases
BioCyc	NMEN122586:GHGG-1387-MONOMER.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_NEIMB

Accession

Primary (citable) accession number: P64254
Secondary accession number(s): Q9JQX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program