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P64246

- GLNA2_MYCBO

UniProt

P64246 - GLNA2_MYCBO

Protein

Probable glutamine synthetase 2

Gene

glnA2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamine synthetase 2 (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase 2
    Gene namesi
    Name:glnA2
    Ordered Locus Names:Mb2246c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable glutamine synthetase 2PRO_0000153245Add
    BLAST

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb2246c.

    Structurei

    3D structure databases

    ProteinModelPortaliP64246.
    SMRiP64246. Positions 5-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005156.
    KOiK01915.
    OMAiVHDAAPN.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    PROSITEiPS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P64246-1 [UniParc]FASTAAdd to Basket

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    MDRQKEFVLR TLEERDIRFV RLWFTDVLGF LKSVAIAPAE LEGAFEEGIG    50
    FDGSSIEGFA RVSESDTVAH PDPSTFQVLP WATSSGHHHS ARMFCDITMP 100
    DGSPSWADPR HVLRRQLTKA GELGFSCYVH PEIEFFLLKP GPEDGSVPVP 150
    VDNAGYFDQA VHDSALNFRR HAIDALEFMG ISVEFSHHEG APGQQEIDLR 200
    FADALSMADN VMTFRYVIKE VALEEGARAS FMPKPFGQHP GSAMHTHMSL 250
    FEGDVNAFHS ADDPLQLSEV GKSFIAGILE HACEISAVTN QWVNSYKRLV 300
    QGGEAPTAAS WGAANRSALV RVPMYTPHKT SSRRVEVRSP DSACNPYLTF 350
    AVLLAAGLRG VEKGYVLGPQ AEDNVWDLTP EERRAMGYRE LPSSLDSALR 400
    AMEASELVAE ALGEHVFDFF LRNKRTEWAN YRSHVTPYEL RTYLSL 446
    Length:446
    Mass (Da):49,608
    Last modified:October 11, 2004 - v1
    Checksum:i86F163FD017829DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43500.1.
    RefSeqiNP_855895.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD97099; CAD97099; Mb2246c.
    GeneIDi1091371.
    KEGGimbo:Mb2246c.
    PATRICi18006634. VBIMycBov88188_2463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43500.1 .
    RefSeqi NP_855895.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P64246.
    SMRi P64246. Positions 5-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2246c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD97099 ; CAD97099 ; Mb2246c .
    GeneIDi 1091371.
    KEGGi mbo:Mb2246c.
    PATRICi 18006634. VBIMycBov88188_2463.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005156.
    KOi K01915.
    OMAi VHDAAPN.
    OrthoDBi EOG6B360N.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    PROSITEi PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiGLNA2_MYCBO
    AccessioniPrimary (citable) accession number: P64246
    Secondary accession number(s): Q10378, X2BK57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3