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P64246 (GLNA2_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutamine synthetase 2

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase 2
Gene names
Name:glnA2
Ordered Locus Names:Mb2246c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Probable glutamine synthetase 2
PRO_0000153245

Sequences

Sequence LengthMass (Da)Tools
P64246 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 86F163FD017829DD

FASTA44649,608
        10         20         30         40         50         60 
MDRQKEFVLR TLEERDIRFV RLWFTDVLGF LKSVAIAPAE LEGAFEEGIG FDGSSIEGFA 

        70         80         90        100        110        120 
RVSESDTVAH PDPSTFQVLP WATSSGHHHS ARMFCDITMP DGSPSWADPR HVLRRQLTKA 

       130        140        150        160        170        180 
GELGFSCYVH PEIEFFLLKP GPEDGSVPVP VDNAGYFDQA VHDSALNFRR HAIDALEFMG 

       190        200        210        220        230        240 
ISVEFSHHEG APGQQEIDLR FADALSMADN VMTFRYVIKE VALEEGARAS FMPKPFGQHP 

       250        260        270        280        290        300 
GSAMHTHMSL FEGDVNAFHS ADDPLQLSEV GKSFIAGILE HACEISAVTN QWVNSYKRLV 

       310        320        330        340        350        360 
QGGEAPTAAS WGAANRSALV RVPMYTPHKT SSRRVEVRSP DSACNPYLTF AVLLAAGLRG 

       370        380        390        400        410        420 
VEKGYVLGPQ AEDNVWDLTP EERRAMGYRE LPSSLDSALR AMEASELVAE ALGEHVFDFF 

       430        440 
LRNKRTEWAN YRSHVTPYEL RTYLSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248341 Genomic DNA. Translation: CAD97099.1.
RefSeqNP_855895.1. NC_002945.3.

3D structure databases

ProteinModelPortalP64246.
SMRP64246. Positions 5-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2246c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD97099; CAD97099; Mb2246c.
GeneID1091371.
KEGGmbo:Mb2246c.
PATRIC18006634. VBIMycBov88188_2463.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0174.
HOGENOMHOG000005156.
KOK01915.
OMAAEDDVWS.
OrthoDBEOG6B360N.
ProtClustDBCLSK791706.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
PROSITEPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA2_MYCBO
AccessionPrimary (citable) accession number: P64246
Secondary accession number(s): Q10378
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families