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Protein

Probable glutamine synthetase 2

Gene

glnA2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.1.2. 3494.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine synthetase 2 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase 2
Gene namesi
Name:glnA2
Ordered Locus Names:Mb2246c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glutamine synthetase 2PRO_0000153245Add
BLAST

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi233413.Mb2246c.

Structurei

3D structure databases

ProteinModelPortaliP64246.
SMRiP64246. Positions 5-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiRVYESDM.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRQKEFVLR TLEERDIRFV RLWFTDVLGF LKSVAIAPAE LEGAFEEGIG
60 70 80 90 100
FDGSSIEGFA RVSESDTVAH PDPSTFQVLP WATSSGHHHS ARMFCDITMP
110 120 130 140 150
DGSPSWADPR HVLRRQLTKA GELGFSCYVH PEIEFFLLKP GPEDGSVPVP
160 170 180 190 200
VDNAGYFDQA VHDSALNFRR HAIDALEFMG ISVEFSHHEG APGQQEIDLR
210 220 230 240 250
FADALSMADN VMTFRYVIKE VALEEGARAS FMPKPFGQHP GSAMHTHMSL
260 270 280 290 300
FEGDVNAFHS ADDPLQLSEV GKSFIAGILE HACEISAVTN QWVNSYKRLV
310 320 330 340 350
QGGEAPTAAS WGAANRSALV RVPMYTPHKT SSRRVEVRSP DSACNPYLTF
360 370 380 390 400
AVLLAAGLRG VEKGYVLGPQ AEDNVWDLTP EERRAMGYRE LPSSLDSALR
410 420 430 440
AMEASELVAE ALGEHVFDFF LRNKRTEWAN YRSHVTPYEL RTYLSL
Length:446
Mass (Da):49,608
Last modified:October 10, 2004 - v1
Checksum:i86F163FD017829DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43500.1.
RefSeqiNP_855895.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43500; CDO43500; Mb2246c.
GeneIDi1091371.
KEGGimbo:Mb2246c.
PATRICi18006634. VBIMycBov88188_2463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43500.1.
RefSeqiNP_855895.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP64246.
SMRiP64246. Positions 5-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233413.Mb2246c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43500; CDO43500; Mb2246c.
GeneIDi1091371.
KEGGimbo:Mb2246c.
PATRICi18006634. VBIMycBov88188_2463.

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiRVYESDM.
OrthoDBiEOG6B360N.

Enzyme and pathway databases

BRENDAi6.3.1.2. 3494.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiGLNA2_MYCBO
AccessioniPrimary (citable) accession number: P64246
Secondary accession number(s): Q10378, X2BK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2004
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.