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P64246

- GLNA2_MYCBO

UniProt

P64246 - GLNA2_MYCBO

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Protein

Probable glutamine synthetase 2

Gene

glnA2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine synthetase 2 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase 2
Gene namesi
Name:glnA2
Ordered Locus Names:Mb2246c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glutamine synthetase 2PRO_0000153245Add
BLAST

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi233413.Mb2246c.

Structurei

3D structure databases

ProteinModelPortaliP64246.
SMRiP64246. Positions 5-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiVHDAAPN.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64246-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRQKEFVLR TLEERDIRFV RLWFTDVLGF LKSVAIAPAE LEGAFEEGIG
60 70 80 90 100
FDGSSIEGFA RVSESDTVAH PDPSTFQVLP WATSSGHHHS ARMFCDITMP
110 120 130 140 150
DGSPSWADPR HVLRRQLTKA GELGFSCYVH PEIEFFLLKP GPEDGSVPVP
160 170 180 190 200
VDNAGYFDQA VHDSALNFRR HAIDALEFMG ISVEFSHHEG APGQQEIDLR
210 220 230 240 250
FADALSMADN VMTFRYVIKE VALEEGARAS FMPKPFGQHP GSAMHTHMSL
260 270 280 290 300
FEGDVNAFHS ADDPLQLSEV GKSFIAGILE HACEISAVTN QWVNSYKRLV
310 320 330 340 350
QGGEAPTAAS WGAANRSALV RVPMYTPHKT SSRRVEVRSP DSACNPYLTF
360 370 380 390 400
AVLLAAGLRG VEKGYVLGPQ AEDNVWDLTP EERRAMGYRE LPSSLDSALR
410 420 430 440
AMEASELVAE ALGEHVFDFF LRNKRTEWAN YRSHVTPYEL RTYLSL
Length:446
Mass (Da):49,608
Last modified:October 11, 2004 - v1
Checksum:i86F163FD017829DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43500.1.
RefSeqiNP_855895.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97099; CAD97099; Mb2246c.
GeneIDi1091371.
KEGGimbo:Mb2246c.
PATRICi18006634. VBIMycBov88188_2463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43500.1 .
RefSeqi NP_855895.1. NC_002945.3.

3D structure databases

ProteinModelPortali P64246.
SMRi P64246. Positions 5-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2246c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97099 ; CAD97099 ; Mb2246c .
GeneIDi 1091371.
KEGGi mbo:Mb2246c.
PATRICi 18006634. VBIMycBov88188_2463.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005156.
KOi K01915.
OMAi VHDAAPN.
OrthoDBi EOG6B360N.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiGLNA2_MYCBO
AccessioniPrimary (citable) accession number: P64246
Secondary accession number(s): Q10378, X2BK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3