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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei596For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SA1959
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353812 – 601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST600

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP64228.
SMRiP64228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini284 – 423SIS 1UniRule annotationAdd BLAST140
Domaini453 – 591SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P64228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGY DNAKELLLKG LEKLEYRGYD SAGIAVVNDD NTTVFKEKGR
60 70 80 90 100
IAELRKVADS SDFDGPVGIG HTRWATHGVP NHENSHPHQS SNGRFTLVHN
110 120 130 140 150
GVIENYEELK GEYLQGVSFI SETDTEVIVQ LVEYFSNQGL STEEAFTKVV
160 170 180 190 200
SLLHGSYALG LLDAEDKDTI YVAKNKSPLL LGVGEGFNVI ASDALAMLQV
210 220 230 240 250
TSEYKEIHDH EIVIVKKDEV IIKDADGNVV ERDSYIAEID ASDAEKGVYA
260 270 280 290 300
HYMLKEIHEQ PAVMRRIIQE YQDAEGNLKI DQDIINDVKE ADRIYVIAAG
310 320 330 340 350
TSYHAGLVGK EFLEKWAGVP TEVHVASEFV YNMPLLSEKP LFVYISQSGE
360 370 380 390 400
TADSRAVLVE TNKLGHKSLT ITNVAGSTLS READHTLLLH AGPEIAVAST
410 420 430 440 450
KAYTAQIAVL SILSQIVAKE HGREADIDLL RELAKVTTAI EAIVDDAPIM
460 470 480 490 500
EQIATDFLET TRNAFFIGRT IDYNVSLEGA LKLKEISYIQ AEGFAGGELK
510 520 530 540 550
HGTIALIEDG TPVVALATQE NVNLSIRGNV KEVVARGAHP CIISMEGLEK
560 570 580 590 600
EGDTYVIPHV HELLTPLVSV VALQLISYYA ALHRDLDVDK PRNLAKSVTV

E
Length:601
Mass (Da):65,835
Last modified:January 23, 2007 - v2
Checksum:iC2A7B4AE4E829F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43247.1.
PIRiF90010.
RefSeqiWP_000334463.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43247; BAB43247; BAB43247.
KEGGisau:SA1959.

Similar proteinsi

Entry informationi

Entry nameiGLMS_STAAN
AccessioniPrimary (citable) accession number: P64228
Secondary accession number(s): Q99SA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome