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P64228

- GLMS_STAAN

UniProt

P64228 - GLMS_STAAN

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, SA1959
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei596 – 5961For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:SA1959
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135381Add
BLAST

Proteomic databases

PRIDEiP64228.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi158879.SA1959.

Structurei

3D structure databases

ProteinModelPortaliP64228.
SMRiP64228. Positions 2-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 423140SIS 1
Add
BLAST
Domaini453 – 591139SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P64228-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGY DNAKELLLKG LEKLEYRGYD SAGIAVVNDD NTTVFKEKGR    50
IAELRKVADS SDFDGPVGIG HTRWATHGVP NHENSHPHQS SNGRFTLVHN 100
GVIENYEELK GEYLQGVSFI SETDTEVIVQ LVEYFSNQGL STEEAFTKVV 150
SLLHGSYALG LLDAEDKDTI YVAKNKSPLL LGVGEGFNVI ASDALAMLQV 200
TSEYKEIHDH EIVIVKKDEV IIKDADGNVV ERDSYIAEID ASDAEKGVYA 250
HYMLKEIHEQ PAVMRRIIQE YQDAEGNLKI DQDIINDVKE ADRIYVIAAG 300
TSYHAGLVGK EFLEKWAGVP TEVHVASEFV YNMPLLSEKP LFVYISQSGE 350
TADSRAVLVE TNKLGHKSLT ITNVAGSTLS READHTLLLH AGPEIAVAST 400
KAYTAQIAVL SILSQIVAKE HGREADIDLL RELAKVTTAI EAIVDDAPIM 450
EQIATDFLET TRNAFFIGRT IDYNVSLEGA LKLKEISYIQ AEGFAGGELK 500
HGTIALIEDG TPVVALATQE NVNLSIRGNV KEVVARGAHP CIISMEGLEK 550
EGDTYVIPHV HELLTPLVSV VALQLISYYA ALHRDLDVDK PRNLAKSVTV 600
E 601
Length:601
Mass (Da):65,835
Last modified:January 23, 2007 - v2
Checksum:iC2A7B4AE4E829F0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43247.1.
PIRiF90010.
RefSeqiNP_375268.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43247; BAB43247; BAB43247.
GeneIDi1124864.
KEGGisau:SA1959.
PATRICi19576382. VBIStaAur116463_2118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43247.1 .
PIRi F90010.
RefSeqi NP_375268.1. NC_002745.2.

3D structure databases

ProteinModelPortali P64228.
SMRi P64228. Positions 2-601.
ModBasei Search...

Protein-protein interaction databases

STRINGi 158879.SA1959.

Proteomic databases

PRIDEi P64228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB43247 ; BAB43247 ; BAB43247 .
GeneIDi 1124864.
KEGGi sau:SA1959.
PATRICi 19576382. VBIStaAur116463_2118.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-2096-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. "Shotgun proteomic analysis of total protein extract of S. aureus S30 versus N315."
    Stenz L.
    Submitted (NOV-2005) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiGLMS_STAAN
AccessioniPrimary (citable) accession number: P64228
Secondary accession number(s): Q99SA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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