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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Enzyme regulationi

Allosteric enzyme. Activity is modulated by K+, divalent cations, UTP, and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme (By similarity).By similarity

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111ZincUniRule annotation1
Metal bindingi114ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:STY2427, t0662
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001194412 – 222GTP cyclohydrolase 1Add BLAST221

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi220341.STY2427

Structurei

3D structure databases

ProteinModelPortaliP64210
SMRiP64210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EUJ Bacteria
COG0302 LUCA
HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P64210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLSKEAAL VHDALVARGL ETPLRPPMDE LDNETRKSLI AGHMTEIMQL
60 70 80 90 100
LNLDLSDDSL METPHRIAKM YVDEIFAGLD YANFPKITLI ENKMKVDEMV
110 120 130 140 150
TVRDITLTST CEHHFVTIDG KATVAYIPKD SVIGLSKINR IVQFFAQRPQ
160 170 180 190 200
VQERLTQQIL TALQTLLGTN NVAVSIDAVH YCVKARGIRD ATSATTTTSL
210 220
GGLFKSSQNT RQEFLRAVRH HP
Length:222
Mass (Da):24,771
Last modified:January 23, 2007 - v2
Checksum:i906EB3877D1F444E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD02575.1
AE014613 Genomic DNA Translation: AAO68362.1
RefSeqiNP_456752.1, NC_003198.1
WP_001139611.1, NZ_PHKG01000001.1

Genome annotation databases

EnsemblBacteriaiAAO68362; AAO68362; t0662
CAD02575; CAD02575; CAD02575
GeneIDi1248757
KEGGistt:t0662
sty:STY2427
PATRICifig|220341.7.peg.2453

Similar proteinsi

Entry informationi

Entry nameiGCH1_SALTI
AccessioniPrimary (citable) accession number: P64210
Secondary accession number(s): Q8XFN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health