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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei291Proton donorUniRule annotation1
Active sitei312UniRule annotation1
Active sitei426UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:gbs0437
OrganismiStreptococcus agalactiae serotype III (strain NEM316)
Taxonomic identifieri211110 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000823 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807351 – 449Glucose-6-phosphate isomeraseAdd BLAST449

Structurei

3D structure databases

ProteinModelPortaliP64195
SMRiP64195
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiVERCKAM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P64195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHITFDYSK VLGQFVGEHE LDYLQPQVSA ADAFLRQGTG PGSDFLGWMD
60 70 80 90 100
LPENYDKEEF SRIQKAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNNHF
110 120 130 140 150
ANLQTAEERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV
210 220 230 240 250
VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI
260 270 280 290 300
AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GYRNLFETVV RVEKPRKNVT IPELTEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPTQD AYTLGYTIYF
410 420 430 440
FELAIGLSGY LNSVNPFDQP GVEAYKRNMF ALLGKPGFEE LSAELNARL
Length:449
Mass (Da):49,585
Last modified:October 11, 2004 - v1
Checksum:i5199E72DE0CDCE1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL766845 Genomic DNA Translation: CAD46081.1
RefSeqiWP_000148892.1, NC_004368.1

Genome annotation databases

EnsemblBacteriaiCAD46081; CAD46081; CAD46081
KEGGisan:pgi

Similar proteinsi

Entry informationi

Entry nameiG6PI_STRA3
AccessioniPrimary (citable) accession number: P64195
Secondary accession number(s): Q8E1F3, Q8E6X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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