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P64195 (G6PI_STRA3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:gbs0437
OrganismStreptococcus agalactiae serotype III [Complete proteome] [HAMAP]
Taxonomic identifier216495 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180735

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
P64195 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5199E72DE0CDCE1B

FASTA44949,585
        10         20         30         40         50         60 
MTHITFDYSK VLGQFVGEHE LDYLQPQVSA ADAFLRQGTG PGSDFLGWMD LPENYDKEEF 

        70         80         90        100        110        120 
SRIQKAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNNHF ANLQTAEERK APQILYAGNS 

       130        140        150        160        170        180 
ISSTYLADLV EYVQDKEFSV NVISKSGTTT EPAIAFRVFK ELLVKKYGQE EANKRIYATT 

       190        200        210        220        230        240 
DKVKGAVKVE ADANNWETFV VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD 

       250        260        270        280        290        300 
LSSDKISENI AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 

       310        320        330        340        350        360 
YPTSANFSTD LHSLGQFIQE GYRNLFETVV RVEKPRKNVT IPELTEDLDG LGYLQGKDVD 

       370        380        390        400        410        420 
FVNKKATDGV LLAHTDGGVP NMFVTLPTQD AYTLGYTIYF FELAIGLSGY LNSVNPFDQP 

       430        440 
GVEAYKRNMF ALLGKPGFEE LSAELNARL

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References

[1]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316 / Serotype III.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL766845 Genomic DNA. Translation: CAD46081.1.
RefSeqNP_734905.1. NC_004368.1.

3D structure databases

ProteinModelPortalP64195.
SMRP64195. Positions 4-449.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000002057; EBSTRP00000001975; EBSTRG00000002057.
GeneID1031617.
GenomeReviewsGene locus gbs0437 in contig AL732656_GR.
KEGGsan:gbs0437.
PATRIC19636694. VBIStrAga3577_0451.

Organism-specific databases

GenoListgbs0437.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000026848.
HOGENOMHBG615843.
OMADNLDGLN.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycSAGA211110:GBS0437-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STRA3
AccessionPrimary (citable) accession number: P64195
Secondary accession number(s): Q8E1F3, Q8E6X1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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