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P64182 (GLPD1_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase 1
EC=1.1.5.3
Gene names
Name:glpD1
Synonyms:glpD
Ordered Locus Names:Rv2249c, MT2309
ORF Names:MTCY427.31c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence caution

The sequence AAK46593.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycerol metabolism
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcell wall

Inferred from direct assay. Source: MTBBASE

glycerol-3-phosphate dehydrogenase complex

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionsn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Glycerol-3-phosphate dehydrogenase 1
PRO_0000126100

Regions

Nucleotide binding28 – 5629FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P64182 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 164A136FEEB402E6

FASTA51654,176
        10         20         30         40         50         60 
MLMPHSAALN AARRSADLTA LADGGALDVI VIGGGITGVG IALDAATRGL TVALVEKHDL 

        70         80         90        100        110        120 
AFGTSRWSSK LVHGGLRYLA SGNVGIARRS AVERGILMTR NAPHLVHAMP QLVPLLPSMG 

       130        140        150        160        170        180 
HTKRALVRAG FLAGDALRVL AGTPAATLPR SRRIPASRVV EIAPTVRRDG LDGGLLAYDG 

       190        200        210        220        230        240 
QLIDDARLVM AVARTAAQHG ARILTYVGAS NVTGTSVELT DRRTRQSFAL SARAVINAAG 

       250        260        270        280        290        300 
VWAGEIDPSL RLRPSRGTHL VFDAKSFANP TAALTIPIPG ELNRFVFAMP EQLGRIYLGL 

       310        320        330        340        350        360 
TDEDAPGPIP DVPQPSSEEI TFLLDTVNTA LGTAVGTKDV IGAYAGLRPL IDTGGAGVQG 

       370        380        390        400        410        420 
RTADVSRDHA VFESPSGVIS VVGGKLTEYR YMAEDVLNRA ITLRHLRAAK CRTRNLPLIG 

       430        440        450        460        470        480 
APANPGPAPG SGAGLPESLV ARYGAEAANV AAAATCERPT EPVADGIDVT RAEFEYAVTH 

       490        500        510 
EGALDVDDIL DRRTRIGLVP RDRERVVAVA KEFLSR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842579 Genomic DNA. Translation: CAA94644.1.
AE000516 Genomic DNA. Translation: AAK46593.1. Different initiation.
PIRE70779.
RefSeqNP_216765.1. NC_000962.2.
NP_336779.1. NC_002755.2.

3D structure databases

ProteinModelPortalP64182.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002124; EBMYCP00000002124; EBMYCG00000002122.
EBMYCT00000069146; EBMYCP00000067205; EBMYCG00000069141.
GeneID887276.
924116.
GenomeReviewsGene locus MT2309 in contig AE000516_GR.
Gene locus Rv2249c in contig AL123456_GR.
KEGGmtc:MT2309.
mtu:Rv2249c.
PATRIC18126825. VBIMycTub22151_2523.
TIGRMT2309.

Organism-specific databases

TubercuListRv2249c.

Phylogenomic databases

GeneTreeEBGT00050000015584.
HOGENOMHBG720894.
OMAAREICAM.
PhylomeDBP64182.
ProtClustDBCLSK872035.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
KOK00111.
PfamPF01266. DAO. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
PROSITEPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPD1_MYCTU
AccessionPrimary (citable) accession number: P64182
Secondary accession number(s): Q10502
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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