Fumarate reductase flavoprotein subunit - Mycobacterium bovis

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Reviewed, UniProtKB/Swiss-Prot P64175 (FRDA_MYCBO)

Last modified November 25, 2008. Version 28. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Fumarate reductase flavoprotein subunit
EC=1.3.99.1

Gene names

Name:	frdA
Ordered Locus Names:	Mb1578

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 FAD covalently per subunit By similarity.
Subunit structure	Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anaerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

583

Fumarate reductase flavoprotein subunit

PRO_0000158665

Regions

Nucleotide binding

15

FAD By similarity

Sites

Active site

1

By similarity

Active site

1

By similarity

Amino acid modifications

Modified residue

1

Tele-8alpha-FAD histidine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P64175-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5B1726413767FA63
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583

63,763

        10         20         30         40         50         60 
MTAQHNIVVI GGGGAGLRAA IAIAETNPHL DVAIVSKVYP MRSHTVSAEG GAAAVTGDDD 

        70         80         90        100        110        120 
SLDEHAHDTV SGGDWLCDQD AVEAFVAEAP KELVQLEHWG CPWSRKPDGR VAVRPFGGMK 

       130        140        150        160        170        180 
KLRTWFAADK TGFHLLHTLF QRLLTYSDVM RYDEWFATTL LVDDGRVCGL VAIELATGRI 

       190        200        210        220        230        240 
ETILADAVIL CTGGCGRVFP FTTNANIKTG DGMALAFRAG APLKDMEFVQ YHPTGLPFTG 

       250        260        270        280        290        300 
ILITEAARAE GGWLLNKDGY RYLQDYDLGK PTPEPRLRSM ELGPRDRLSQ AFVHEHNKGR 

       310        320        330        340        350        360 
TVDTPYGPVV YLDLRHLGAD LIDAKLPFVR ELCRDYQHID PVVELVPVRP VVHYMMGGVH 

       370        380        390        400        410        420 
TDINGATTLP GLYAAGETAC VSINGANRLG SNSLPELLVF GARAGRAAAD YAARHQKSDR 

       430        440        450        460        470        480 
GPSSAVRAQA RTEALRLERE LSRHGQGGER IADIRADMQA TLESAAGIYR DGPTLTKAVE 

       490        500        510        520        530        540 
EIRVLQERFA TAGIDDHSRT FNTELTALLE LSGMLDVALA IVESGLRREE SRGAHQRTDF 

       550        560        570        580 
PNRDDEHFLA HTLVHRESDG TLRVGYLPVT ITRWPPGERV YGR

References

[1]

"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.

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Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
	BX248339 Genomic DNA. Translation: CAD96245.1.
RefSeq	NP_855230.1.
3D structure databases
HSSP	HSSP built from PDB template 1KF6 based on UniProtKB P00363.
ModBase	Search...
Genome annotation databases
GeneID	1092446.
GenomeReviews	Gene locus Mb1578 in contig BX248333_GR.
KEGG	mbo:Mb1578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P64175.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DHase_flav_C. IPR005884. Fum_red_fp. IPR001100. Pyr_nuc-diS_OxRdtase. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00411. PNDRDTASEI.
TIGRFAMs	TIGR01176. fum_red_Fp. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_MYCBO

Accession

Primary (citable) accession number: P64175
Secondary accession number(s): Q10760

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents