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P64174 (FRDA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate reductase flavoprotein subunit
EC=1.3.99.1
Gene names
Name:frdA
Ordered Locus Names:Rv1552, MT1603
ORF Names:MTCY48.13c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + acceptor = fumarate + reduced acceptor.

Cofactor

Binds 1 FAD covalently per subunit By similarity.

Subunit structure

Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Fumarate reductase flavoprotein subunit
PRO_0000158664

Regions

Nucleotide binding8 – 2215FAD By similarity

Sites

Active site2321 By similarity
Active site2481 By similarity

Amino acid modifications

Modified residue441Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
P64174 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5B1726413767FA63

FASTA58363,763
        10         20         30         40         50         60 
MTAQHNIVVI GGGGAGLRAA IAIAETNPHL DVAIVSKVYP MRSHTVSAEG GAAAVTGDDD 

        70         80         90        100        110        120 
SLDEHAHDTV SGGDWLCDQD AVEAFVAEAP KELVQLEHWG CPWSRKPDGR VAVRPFGGMK 

       130        140        150        160        170        180 
KLRTWFAADK TGFHLLHTLF QRLLTYSDVM RYDEWFATTL LVDDGRVCGL VAIELATGRI 

       190        200        210        220        230        240 
ETILADAVIL CTGGCGRVFP FTTNANIKTG DGMALAFRAG APLKDMEFVQ YHPTGLPFTG 

       250        260        270        280        290        300 
ILITEAARAE GGWLLNKDGY RYLQDYDLGK PTPEPRLRSM ELGPRDRLSQ AFVHEHNKGR 

       310        320        330        340        350        360 
TVDTPYGPVV YLDLRHLGAD LIDAKLPFVR ELCRDYQHID PVVELVPVRP VVHYMMGGVH 

       370        380        390        400        410        420 
TDINGATTLP GLYAAGETAC VSINGANRLG SNSLPELLVF GARAGRAAAD YAARHQKSDR 

       430        440        450        460        470        480 
GPSSAVRAQA RTEALRLERE LSRHGQGGER IADIRADMQA TLESAAGIYR DGPTLTKAVE 

       490        500        510        520        530        540 
EIRVLQERFA TAGIDDHSRT FNTELTALLE LSGMLDVALA IVESGLRREE SRGAHQRTDF 

       550        560        570        580 
PNRDDEHFLA HTLVHRESDG TLRVGYLPVT ITRWPPGERV YGR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAA98311.1.
AE000516 Genomic DNA. Translation: AAK45870.1.
PIRE70762.
RefSeqNP_216068.1. NC_000962.2.
NP_336056.1. NC_002755.2.

3D structure databases

ProteinModelPortalP64174.
SMRP64174. Positions 3-577.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001531; EBMYCP00000001531; EBMYCG00000001531.
EBMYCT00000072929; EBMYCP00000070988; EBMYCG00000072924.
GeneID886376.
924332.
GenomeReviewsGene locus MT1603 in contig AE000516_GR.
Gene locus Rv1552 in contig AL123456_GR.
KEGGmtc:MT1603.
mtu:Rv1552.
PATRIC18125294. VBIMycTub22151_1761.
TIGRMT1603.

Organism-specific databases

TubercuListRv1552.

Phylogenomic databases

GeneTreeEBGT00050000015552.
HOGENOMHBG293998.
OMARFDEYFV.
PhylomeDBP64174.
ProtClustDBPRK09231.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005884. Fum_red_fp.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00244.
PANTHERPTHR11632:SF5. PTHR11632:SF5. 1 hit.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR01176. Fum_red_Fp. 1 hit.
TIGR01812. SdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDA_MYCTU
AccessionPrimary (citable) accession number: P64174
Secondary accession number(s): Q10760
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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