Fumarate reductase flavoprotein subunit - Mycobacterium tuberculosis

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Reviewed, UniProtKB/Swiss-Prot P64174 (FRDA_MYCTU)

Last modified June 16, 2009. Version 35. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Fumarate reductase flavoprotein subunit
EC=1.3.99.1

Gene names

Name:	frdA
Ordered Locus Names:	Rv1552, MT1603
ORF Names:	MTCY48.13c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 FAD covalently per subunit By similarity.
Subunit structure	Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anaerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

583

Fumarate reductase flavoprotein subunit

PRO_0000158664

Regions

Nucleotide binding

15

FAD By similarity

Sites

Active site

1

By similarity

Active site

1

By similarity

Amino acid modifications

Modified residue

1

Tele-8alpha-FAD histidine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P64174-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5B1726413767FA63
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583

63,763

        10         20         30         40         50         60 
MTAQHNIVVI GGGGAGLRAA IAIAETNPHL DVAIVSKVYP MRSHTVSAEG GAAAVTGDDD 

        70         80         90        100        110        120 
SLDEHAHDTV SGGDWLCDQD AVEAFVAEAP KELVQLEHWG CPWSRKPDGR VAVRPFGGMK 

       130        140        150        160        170        180 
KLRTWFAADK TGFHLLHTLF QRLLTYSDVM RYDEWFATTL LVDDGRVCGL VAIELATGRI 

       190        200        210        220        230        240 
ETILADAVIL CTGGCGRVFP FTTNANIKTG DGMALAFRAG APLKDMEFVQ YHPTGLPFTG 

       250        260        270        280        290        300 
ILITEAARAE GGWLLNKDGY RYLQDYDLGK PTPEPRLRSM ELGPRDRLSQ AFVHEHNKGR 

       310        320        330        340        350        360 
TVDTPYGPVV YLDLRHLGAD LIDAKLPFVR ELCRDYQHID PVVELVPVRP VVHYMMGGVH 

       370        380        390        400        410        420 
TDINGATTLP GLYAAGETAC VSINGANRLG SNSLPELLVF GARAGRAAAD YAARHQKSDR 

       430        440        450        460        470        480 
GPSSAVRAQA RTEALRLERE LSRHGQGGER IADIRADMQA TLESAAGIYR DGPTLTKAVE 

       490        500        510        520        530        540 
EIRVLQERFA TAGIDDHSRT FNTELTALLE LSGMLDVALA IVESGLRREE SRGAHQRTDF 

       550        560        570        580 
PNRDDEHFLA HTLVHRESDG TLRVGYLPVT ITRWPPGERV YGR

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.

expand/collapse author list

Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R.

expand/collapse author list

Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
	BX842577 Genomic DNA. Translation: CAA98311.1. AE000516 Genomic DNA. Translation: AAK45870.1.
PIR	E70762.
RefSeq	NP_216068.1. NP_336056.1.
3D structure databases
HSSP	HSSP built from PDB template 1KF6 based on UniProtKB P00363.
ModBase	Search...
Genome annotation databases
GeneID	886376. 924332.
GenomeReviews	Gene locus MT1603 in contig AE000516_GR. Gene locus Rv1552 in contig AL123456_GR.
KEGG	mtc:MT1603. mtu:Rv1552.
TIGR	MT1603.
Organism-specific databases
TubercuList	Rv1552.
Phylogenomic databases
HOGENOM	P64174.
OMA	P64174. TITKSQP.
Enzyme and pathway databases
BRENDA	1.3.99.1. 809.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR005884. Fum_red_fp. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
TIGRFAMs	TIGR01176. fum_red_Fp. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_MYCTU

Accession

Primary (citable) accession number: P64174
Secondary accession number(s): Q10760

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents