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P64141 (DHPS_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydropteroate synthase

Short name=DHPS
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene names
Name:folP
Ordered Locus Names:SAV0514
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Dihydropteroate synthase
PRO_0000168221

Regions

Domain1 – 251251Pterin-binding
Region51 – 522Substrate binding By similarity

Sites

Metal binding111Magnesium By similarity
Binding site191Substrate By similarity
Binding site841Substrate By similarity
Binding site1031Substrate By similarity
Binding site1671Substrate By similarity
Binding site2031Substrate By similarity
Binding site2391Substrate By similarity
Binding site2411Substrate By similarity

Secondary structure

........................................ 267
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P64141 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A2E41F5C5544D86C

FASTA26729,533
        10         20         30         40         50         60 
MTKTKIMGIL NVTPDSFSDG GKFNNVETAI NRVKAMIDEG ADIIDVGGVS TRPGHEMVTL 

        70         80         90        100        110        120 
EEELNRVLPV VEAIVGFDVK ISVDTFRSEV AEACLKLGVD MINDQWAGLY DHRMFQIVAK 

       130        140        150        160        170        180 
YDAEIILMHN GNGNRDEPVV EEMLTSLLAQ AHQAKIAGIP SNKIWLDPGI GFAKTRNEEA 

       190        200        210        220        230        240 
EVMARLDELV ATEYPVLLAT SRKRFTKEMM GYDTTPVERD EVTAATTAYG IMKGVRAVRV 

       250        260 
HNVELNAKLA KGIDFLKENE NARHNLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000017 Genomic DNA. Translation: BAB56676.1.
RefSeqNP_371038.1. NC_002758.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HB7X-ray1.95A/B1-267[»]
ProteinModelPortalP64141.
SMRP64141. Positions 2-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158878.SAV0514.

2D gel databases

World-2DPAGE0002:P64141.

Proteomic databases

PRIDEP64141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB56676; BAB56676; SAV0514.
GeneID1120474.
KEGGsav:SAV0514.
PATRIC19561650. VBIStaAur52173_0518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
HOGENOMHOG000217509.
KOK00796.
OMADCWISVD.
OrthoDBEOG67T5P5.
PhylomeDBP64141.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-518-MONOMER.
UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS_STAAM
AccessionPrimary (citable) accession number: P64141
Secondary accession number(s): Q99W89
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways