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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:SAV1216
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000830461 – 311Methionyl-tRNA formyltransferaseAdd BLAST311

Proteomic databases

PaxDbiP64136
PRIDEiP64136

2D gel databases

World-2DPAGEi0002:P64136

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1216

Structurei

3D structure databases

ProteinModelPortaliP64136
SMRiP64136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
PhylomeDBiP64136

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

P64136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKIIFMGTP DFSTTVLEML IAEHDVIAVV TQPDRPVGRK RVMTPPPVKK
60 70 80 90 100
VAMKYDLPVY QPEKLSGSEE LEQLLQLDVD LIVTAAFGQL LPESLLALPK
110 120 130 140 150
LGAINVHASL LPKYRGGAPI HQAIIDGEQE TGITIMYMVK KLDAGNIISQ
160 170 180 190 200
QAIKIEENDN VGTMHDKLSV LGADLLKETL PSIIEGTNES VPQDDTQATF
210 220 230 240 250
ASNIRREDER ISWNKPGRQV FNQIRGLSPW PVAYTTMDDT NLKIYDAELV
260 270 280 290 300
ETNKINEPGT IIETTKKAII VATNDNEAVA IKDMQLAGKK RMLAANYLSG
310
AQNTLVGKKL I
Length:311
Mass (Da):34,226
Last modified:October 11, 2004 - v1
Checksum:i0E40873B5F31867C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57378.1
RefSeqiWP_000161291.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57378; BAB57378; SAV1216
KEGGisav:SAV1216

Similar proteinsi

Entry informationi

Entry nameiFMT_STAAM
AccessioniPrimary (citable) accession number: P64136
Secondary accession number(s): Q99UQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health