Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BMEII0265
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829311 – 306Methionyl-tRNA formyltransferaseAdd BLAST306

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2293

Structurei

3D structure databases

ProteinModelPortaliP64132
SMRiP64132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

P64132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVFMGTPE FSVPILTAII GHGYEVVAAY TQPPRPAGRR GLELTRSPVH
60 70 80 90 100
EKAEQFGIPV FTPKSLKGAE EQDVFASLEA DVAIVVAYGL LLPKAILDAP
110 120 130 140 150
RLGCYNGHAS LLPRWRGAAP IQRAIMAGDA ETGMMIMKMD EGLDTGPVAM
160 170 180 190 200
AEKVAITPDM TAGELHDRLS MIGADLMIRA LGALERESLA LQPQAEEGVT
210 220 230 240 250
YAAKIDKAEA RIDWSKPAKD VHNSIRGLSP FPGAWCEMEI NGAVERVKLQ
260 270 280 290 300
RSTLGEGSGA PGTVLDDRLT IACGEGAVRL ATLQRSGGKP LPAQEFLRGQ

RVTKVL
Length:306
Mass (Da):32,772
Last modified:October 11, 2004 - v1
Checksum:iE6E9DF13AEB6F2F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA Translation: AAL53506.1
PIRiAG3542
RefSeqiWP_004682455.1, NZ_GG703779.1

Genome annotation databases

EnsemblBacteriaiAAL53506; AAL53506; BMEII0265
GeneIDi29595783
KEGGibme:BMEII0265
bmel:DK63_2977
PATRICifig|224914.52.peg.3123

Similar proteinsi

Entry informationi

Entry nameiFMT_BRUME
AccessioniPrimary (citable) accession number: P64132
Secondary accession number(s): Q8YDB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health