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P64057 (DER_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:Rv1713, MT1753
ORF Names:MTCI125.35
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgrowth

Inferred from mutant phenotype. Source: MTBBASE

ribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcell wall

Inferred from direct assay. Source: MTBBASE

intracellular

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463GTPase Der HAMAP MF_00195
PRO_0000179017

Regions

Domain38 – 143106G 1
Domain211 – 319109G 2
Domain373 – 45684KH-like
Nucleotide binding33 – 408GTP 1 Potential
Nucleotide binding80 – 845GTP 1 Potential
Nucleotide binding142 – 1454GTP 1 Potential
Nucleotide binding206 – 2138GTP 2 Potential
Nucleotide binding253 – 2575GTP 2 Potential
Nucleotide binding318 – 3214GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
P64057 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9FBDEA105C6E99C8

FASTA46349,958
        10         20         30         40         50         60 
MTQDGTWVDE SDWQLDDSEI AESGAAPVVA VVGRPNVGKS TLVNRILGRR EAVVQDIPGV 

        70         80         90        100        110        120 
TRDRVCYDAL WTGRRFVVQD TGGWEPNAKG LQRLVAEQAS VAMRTADAVI LVVDAGVGAT 

       130        140        150        160        170        180 
AADEAAARIL LRSGKPVFLA ANKVDSEKGE SDAAALWSLG LGEPHAISAM HGRGVADLLD 

       190        200        210        220        230        240 
GVLAALPEVG ESASASGGPR RVALVGKPNV GKSSLLNKLA GDQRSVVHEA AGTTVDPVDS 

       250        260        270        280        290        300 
LIELGGDVWR FVDTAGLRRK VGQASGHEFY ASVRTHAAID SAEVAIVLID ASQPLTEQDL 

       310        320        330        340        350        360 
RVISMVIEAG RALVLAYNKW DLVDEDRREL LQREIDRELV QVRWAQRVNI SAKTGRAVHK 

       370        380        390        400        410        420 
LVPAMEDALA SWDTRIATGP LNTWLTEVTA ATPPPVRGGK QPRILFATQA TARPPTFVLF 

       430        440        450        460 
TTGFLEAGYR RFLERRLRET FGFDGSPIRV NVRVREKRAG KRR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAB10970.1.
AE000516 Genomic DNA. Translation: AAK46024.1.
PIRH70504.
RefSeqNP_216229.1. NC_000962.2.
NP_336210.1. NC_002755.2.

3D structure databases

ProteinModelPortalP64057.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000320; EBMYCP00000000320; EBMYCG00000000320.
EBMYCT00000071863; EBMYCP00000069922; EBMYCG00000071858.
GeneID885086.
923951.
GenomeReviewsGene locus MT1753 in contig AE000516_GR.
Gene locus Rv1713 in contig AL123456_GR.
KEGGmtc:MT1753.
mtu:Rv1713.
PATRIC18125608. VBIMycTub22151_1918.
TIGRMT1753.

Organism-specific databases

TubercuListRv1713.

Phylogenomic databases

GeneTreeEBGT00050000016947.
HOGENOMHBG592135.
OMAQGADFYA.
PhylomeDBP64057.
ProtClustDBPRK03003.

Family and domain databases

HAMAPMF_00195. GTPase_Der.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.300.20. KH_prok. 1 hit.
KOK03977.
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. Small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_MYCTU
AccessionPrimary (citable) accession number: P64057
Secondary accession number(s): O33212
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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