P64015 (ECHA6_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable enoyl-CoA hydratase echA6
EC=4.2.1.17

Gene names

Name:	echA6
Ordered Locus Names:	Mb0929

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could possibly oxidize fatty acids using specific components By similarity.
Catalytic activity	(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
Sequence similarities	Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-CoA hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Probable enoyl-CoA hydratase echA6		PRO_0000109333

Sequences

	Sequence		Length	Mass (Da)
	P64015 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 23BD1153F0159991	FASTA	243	26,029
	10 20 30 40 50 60 MIGITQAEAV LTIELQRPER RNALNSQLVE ELTQAIRKAG DGSARAIVLT GQGTAFCAGA 70 80 90 100 110 120 DLSGDAFAAD YPDRLIELHK AMDASPMPVV GAINGPAIGA GLQLAMQCDL RVVAPDAFFQ 130 140 150 160 170 180 FPTSKYGLAL DNWSIRRLSS LVGHGRARAM LLSAEKLTAE IALHTGMANR IGTLADAQAW 190 200 210 220 230 240 AAEIARLAPL AIQHAKRVLN DDGAIEEAWP AHKELFDKAW GSQDVIEAQV ARMEKRPPKF QGA

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248337 Genomic DNA. Translation: CAD93790.1.
RefSeq	NP_854586.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P64015.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000016005; EBMYCP00000015840; EBMYCG00000016001.
GeneID	1092860.
GenomeReviews	Gene locus Mb0929 in contig BX248333_GR.
KEGG	mbo:Mb0929.
PATRIC	18003704. VBIMycBov88188_1010.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015506.
HOGENOM	HBG748731.
OMA	WPEHKEL.
ProtClustDB	PRK07854.
Enzyme and pathway databases
BioCyc	MBOV233413:MB0929-MONOMER.
Family and domain databases
InterPro	IPR001753. Crotonase_core. IPR018376. Enoyl-CoA_hyd/isom_CS. [Graphical view]
KO	K01692.
Pfam	PF00378. ECH. 1 hit. [Graphical view]
PROSITE	PS00166. ENOYL_COA_HYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECHA6_MYCBO

Accession

Primary (citable) accession number: P64015
Secondary accession number(s): Q10533

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program