P64004Q8YIT4DUT_BRUMEDeoxyuridine 5'-triphosphate nucleotidohydrolasedUTPase3.6.1.23dUTP pyrophosphatasedutBMEI0358Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)BacteriaPseudomonadotaAlphaproteobacteriaHyphomicrobialesBrucellaceaeBrucella/Ochrobactrum groupBrucellaThe genome sequence of the facultative intracellular pathogen Brucella melitensis.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.dUTP + H2O = diphosphate + dUMP + H(+)Mg(2+)Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.Belongs to the dUTPase family.HydrolaseMagnesiumMetal-bindingNucleotide metabolismsubstratesubstratesubstratesubstrateMTAASSSAPTLGIIRLEHAKGLDLPAYETAGSAGMDLRAAVAEDRQIVLLPGRRTLVPTGLILEIPQGYEVQIRPRSGLAFKNGITCLNTPGTIDSDYRGEVKVLLINLGDDDFRIERGMRIAQAVFAPVIQPKIEERAKISETARGAGGFGSTGTA
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