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P63954

- HISX_STAAW

UniProt

P63954 - HISX_STAAW

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Protein
Histidinol dehydrogenase
Gene
hisD, MW2597
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171NAD By similarity
Binding sitei178 – 1781NAD By similarity
Binding sitei201 – 2011NAD By similarity
Binding sitei224 – 2241Substrate By similarity
Metal bindingi246 – 2461Zinc By similarity
Binding sitei246 – 2461Substrate By similarity
Metal bindingi249 – 2491Zinc By similarity
Binding sitei249 – 2491Substrate By similarity
Active sitei314 – 3141Proton acceptor By similarity
Active sitei315 – 3151Proton acceptor By similarity
Binding sitei315 – 3151Substrate By similarity
Metal bindingi348 – 3481Zinc By similarity
Binding sitei348 – 3481Substrate By similarity
Binding sitei402 – 4021Substrate By similarity
Metal bindingi407 – 4071Zinc By similarity
Binding sitei407 – 4071Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2673-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MW2597
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Histidinol dehydrogenaseUniRule annotation
PRO_0000135853Add
BLAST

Proteomic databases

PRIDEiP63954.

Interactioni

Protein-protein interaction databases

STRINGi196620.MW2597.

Structurei

3D structure databases

ProteinModelPortaliP63954.
SMRiP63954. Positions 18-414.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63954-1 [UniParc]FASTAAdd to Basket

« Hide

MLNAQQFLNQ FSLEAPLDES LYPIIRDICQ EVKVHGDKAL KMYNLTFDHT    50
KTDHLEISHE QIKAAFDTLD EKTKQALQQS YERIKAYQES IKQTNQQLEE 100
SVECYEIYHP LESVGIYVPG GKASYPSTVL MTATLAQVAG VENIVVVTPP 150
QPNGVSQEVL AACYITQVNQ VFQVGGAQSI AALTYGTETI PKVDKIVGPG 200
NQFVAYAKKY LFGQVGIDQI AGPTEIALII DDTADLDAIV YDVFAQAEHD 250
ELARTYVIGE DAQVLKDLES RIAKALPNVD RYDIVSKSIA NQHYLIHASN 300
FDEACHVMNT IAPEHASIQT VNPQPYIEKV KYVGALFIGH YSPEVIGDYV 350
AGPSHVLPTN RTARFTNGLS VNDFLTRNTV IHLSKDTFEQ IADSAQHIAH 400
VEALYNHQQS ILIRQS 416
Length:416
Mass (Da):46,161
Last modified:October 11, 2004 - v1
Checksum:iEE6639C9B503264A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96462.1.
RefSeqiNP_647414.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB96462; BAB96462; BAB96462.
GeneIDi1004733.
KEGGisam:MW2597.
PATRICi19571948. VBIStaAur44266_2685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96462.1 .
RefSeqi NP_647414.1. NC_003923.1.

3D structure databases

ProteinModelPortali P63954.
SMRi P63954. Positions 18-414.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196620.MW2597.

Proteomic databases

PRIDEi P63954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB96462 ; BAB96462 ; BAB96462 .
GeneIDi 1004733.
KEGGi sam:MW2597.
PATRICi 19571948. VBIStaAur44266_2685.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SAUR196620:GJ9Z-2673-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiHISX_STAAW
AccessioniPrimary (citable) accession number: P63954
Secondary accession number(s): Q99QW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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