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P63951

- HISX_MYCBO

UniProt

P63951 - HISX_MYCBO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei129 – 1291NADBy similarity
    Binding sitei193 – 1931NADBy similarity
    Binding sitei221 – 2211NADBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Metal bindingi266 – 2661ZincBy similarity
    Binding sitei266 – 2661SubstrateBy similarity
    Metal bindingi269 – 2691ZincBy similarity
    Binding sitei269 – 2691SubstrateBy similarity
    Active sitei335 – 3351Proton acceptorBy similarity
    Active sitei336 – 3361Proton acceptorBy similarity
    Binding sitei336 – 3361SubstrateBy similarity
    Metal bindingi369 – 3691ZincBy similarity
    Binding sitei369 – 3691SubstrateBy similarity
    Binding sitei423 – 4231SubstrateBy similarity
    Metal bindingi428 – 4281ZincBy similarity
    Binding sitei428 – 4281SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:Mb1625
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Histidinol dehydrogenasePRO_0000135795Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb1625.

    Structurei

    3D structure databases

    ProteinModelPortaliP63951.
    SMRiP63951. Positions 29-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiDEMAMPI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63951-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTRIDLRGA ELTAAELRAA LPRGGADVEA VLPTVRPIVA AVAERGAEAA    50
    LDFGASFDGV RPHAIRVPDA ALDAALAGLD CDVCEALQVM VERTRAVHSG 100
    QRRTDVTTTL GPGATVTERW VPVERVGLYV PGGNAVYPSS VVMNVVPAQA 150
    AGVDSLVVAS PPQAQWDGMP HPTILAAARL LGVDEVWAVG GAQAVALLAY 200
    GGTDTDGAAL TPVDMITGPG NIYVTAAKRL CRSRVGIDAE AGPTEIAILA 250
    DHTADPVHVA ADLISQAEHD ELAASVLVTP SEDLADATDA ELAGQLQTTV 300
    HRERVTAALT GRQSAIVLVD DVDAAVLVVN AYAAEHLEIQ TADAPQVASR 350
    IRSAGAIFVG PWSPVSLGDY CAGSNHVLPT AGCARHSSGL SVQTFLRGIH 400
    VVEYTEAALK DVSGHVITLA TAEDLPAHGE AVRRRFER 438
    Length:438
    Mass (Da):45,378
    Last modified:October 11, 2004 - v1
    Checksum:i608E9A89F0B2BF3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO42874.1.
    RefSeqiNP_855278.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96293; CAD96293; Mb1625.
    GeneIDi1092514.
    KEGGimbo:Mb1625.
    PATRICi18005253. VBIMycBov88188_1774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO42874.1 .
    RefSeqi NP_855278.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P63951.
    SMRi P63951. Positions 29-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96293 ; CAD96293 ; Mb1625 .
    GeneIDi 1092514.
    KEGGi mbo:Mb1625.
    PATRICi 18005253. VBIMycBov88188_1774.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi DEMAMPI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiHISX_MYCBO
    AccessioniPrimary (citable) accession number: P63951
    Secondary accession number(s): O08396, X2BIB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3