Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. Phosphoribosyl isomerase A (priA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei129NADBy similarity1
Binding sitei193NADBy similarity1
Binding sitei221NADBy similarity1
Binding sitei244SubstrateBy similarity1
Metal bindingi266ZincBy similarity1
Binding sitei266SubstrateBy similarity1
Metal bindingi269ZincBy similarity1
Binding sitei269SubstrateBy similarity1
Active sitei335Proton acceptorBy similarity1
Active sitei336Proton acceptorBy similarity1
Binding sitei336SubstrateBy similarity1
Metal bindingi369ZincBy similarity1
Binding sitei369SubstrateBy similarity1
Binding sitei423SubstrateBy similarity1
Metal bindingi428ZincBy similarity1
Binding sitei428SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1683-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BQ2027_MB1625
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357951 – 438Histidinol dehydrogenaseAdd BLAST438

Proteomic databases

PRIDEiP63951

Structurei

3D structure databases

ProteinModelPortaliP63951
SMRiP63951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000243914
OMAiQAEHDPM

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P63951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRIDLRGA ELTAAELRAA LPRGGADVEA VLPTVRPIVA AVAERGAEAA
60 70 80 90 100
LDFGASFDGV RPHAIRVPDA ALDAALAGLD CDVCEALQVM VERTRAVHSG
110 120 130 140 150
QRRTDVTTTL GPGATVTERW VPVERVGLYV PGGNAVYPSS VVMNVVPAQA
160 170 180 190 200
AGVDSLVVAS PPQAQWDGMP HPTILAAARL LGVDEVWAVG GAQAVALLAY
210 220 230 240 250
GGTDTDGAAL TPVDMITGPG NIYVTAAKRL CRSRVGIDAE AGPTEIAILA
260 270 280 290 300
DHTADPVHVA ADLISQAEHD ELAASVLVTP SEDLADATDA ELAGQLQTTV
310 320 330 340 350
HRERVTAALT GRQSAIVLVD DVDAAVLVVN AYAAEHLEIQ TADAPQVASR
360 370 380 390 400
IRSAGAIFVG PWSPVSLGDY CAGSNHVLPT AGCARHSSGL SVQTFLRGIH
410 420 430
VVEYTEAALK DVSGHVITLA TAEDLPAHGE AVRRRFER
Length:438
Mass (Da):45,378
Last modified:October 11, 2004 - v1
Checksum:i608E9A89F0B2BF3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00229.1
RefSeqiNP_855278.1, NC_002945.3
WP_003407943.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42874; CDO42874; Mb1625
PATRICifig|233413.5.peg.1774

Similar proteinsi

Entry informationi

Entry nameiHISX_MYCBO
AccessioniPrimary (citable) accession number: P63951
Secondary accession number(s): A0A1R3XYS9, O08396, X2BIB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health