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P63951

- HISX_MYCBO

UniProt

P63951 - HISX_MYCBO

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NADBy similarity
Binding sitei193 – 1931NADBy similarity
Binding sitei221 – 2211NADBy similarity
Binding sitei244 – 2441SubstrateBy similarity
Metal bindingi266 – 2661ZincBy similarity
Binding sitei266 – 2661SubstrateBy similarity
Metal bindingi269 – 2691ZincBy similarity
Binding sitei269 – 2691SubstrateBy similarity
Active sitei335 – 3351Proton acceptorBy similarity
Active sitei336 – 3361Proton acceptorBy similarity
Binding sitei336 – 3361SubstrateBy similarity
Metal bindingi369 – 3691ZincBy similarity
Binding sitei369 – 3691SubstrateBy similarity
Binding sitei423 – 4231SubstrateBy similarity
Metal bindingi428 – 4281ZincBy similarity
Binding sitei428 – 4281SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Mb1625
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenasePRO_0000135795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1625.

Structurei

3D structure databases

ProteinModelPortaliP63951.
SMRiP63951. Positions 29-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRIDLRGA ELTAAELRAA LPRGGADVEA VLPTVRPIVA AVAERGAEAA
60 70 80 90 100
LDFGASFDGV RPHAIRVPDA ALDAALAGLD CDVCEALQVM VERTRAVHSG
110 120 130 140 150
QRRTDVTTTL GPGATVTERW VPVERVGLYV PGGNAVYPSS VVMNVVPAQA
160 170 180 190 200
AGVDSLVVAS PPQAQWDGMP HPTILAAARL LGVDEVWAVG GAQAVALLAY
210 220 230 240 250
GGTDTDGAAL TPVDMITGPG NIYVTAAKRL CRSRVGIDAE AGPTEIAILA
260 270 280 290 300
DHTADPVHVA ADLISQAEHD ELAASVLVTP SEDLADATDA ELAGQLQTTV
310 320 330 340 350
HRERVTAALT GRQSAIVLVD DVDAAVLVVN AYAAEHLEIQ TADAPQVASR
360 370 380 390 400
IRSAGAIFVG PWSPVSLGDY CAGSNHVLPT AGCARHSSGL SVQTFLRGIH
410 420 430
VVEYTEAALK DVSGHVITLA TAEDLPAHGE AVRRRFER
Length:438
Mass (Da):45,378
Last modified:October 11, 2004 - v1
Checksum:i608E9A89F0B2BF3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42874.1.
RefSeqiNP_855278.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96293; CAD96293; Mb1625.
GeneIDi1092514.
KEGGimbo:Mb1625.
PATRICi18005253. VBIMycBov88188_1774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42874.1 .
RefSeqi NP_855278.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63951.
SMRi P63951. Positions 29-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96293 ; CAD96293 ; Mb1625 .
GeneIDi 1092514.
KEGGi mbo:Mb1625.
PATRICi 18005253. VBIMycBov88188_1774.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiHISX_MYCBO
AccessioniPrimary (citable) accession number: P63951
Secondary accession number(s): O08396, X2BIB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3