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P63951

- HISX_MYCBO

UniProt

P63951 - HISX_MYCBO

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Protein

Histidinol dehydrogenase

Gene
hisD, Mb1625
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei193 – 1931NAD By similarity
Binding sitei221 – 2211NAD By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi266 – 2661Zinc By similarity
Binding sitei266 – 2661Substrate By similarity
Metal bindingi269 – 2691Zinc By similarity
Binding sitei269 – 2691Substrate By similarity
Active sitei335 – 3351Proton acceptor By similarity
Active sitei336 – 3361Proton acceptor By similarity
Binding sitei336 – 3361Substrate By similarity
Metal bindingi369 – 3691Zinc By similarity
Binding sitei369 – 3691Substrate By similarity
Binding sitei423 – 4231Substrate By similarity
Metal bindingi428 – 4281Zinc By similarity
Binding sitei428 – 4281Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Mb1625
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenaseUniRule annotationPRO_0000135795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1625.

Structurei

3D structure databases

ProteinModelPortaliP63951.
SMRiP63951. Positions 29-436.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63951-1 [UniParc]FASTAAdd to Basket

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MLTRIDLRGA ELTAAELRAA LPRGGADVEA VLPTVRPIVA AVAERGAEAA    50
LDFGASFDGV RPHAIRVPDA ALDAALAGLD CDVCEALQVM VERTRAVHSG 100
QRRTDVTTTL GPGATVTERW VPVERVGLYV PGGNAVYPSS VVMNVVPAQA 150
AGVDSLVVAS PPQAQWDGMP HPTILAAARL LGVDEVWAVG GAQAVALLAY 200
GGTDTDGAAL TPVDMITGPG NIYVTAAKRL CRSRVGIDAE AGPTEIAILA 250
DHTADPVHVA ADLISQAEHD ELAASVLVTP SEDLADATDA ELAGQLQTTV 300
HRERVTAALT GRQSAIVLVD DVDAAVLVVN AYAAEHLEIQ TADAPQVASR 350
IRSAGAIFVG PWSPVSLGDY CAGSNHVLPT AGCARHSSGL SVQTFLRGIH 400
VVEYTEAALK DVSGHVITLA TAEDLPAHGE AVRRRFER 438
Length:438
Mass (Da):45,378
Last modified:October 11, 2004 - v1
Checksum:i608E9A89F0B2BF3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42874.1.
RefSeqiNP_855278.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96293; CAD96293; Mb1625.
GeneIDi1092514.
KEGGimbo:Mb1625.
PATRICi18005253. VBIMycBov88188_1774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42874.1 .
RefSeqi NP_855278.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63951.
SMRi P63951. Positions 29-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96293 ; CAD96293 ; Mb1625 .
GeneIDi 1092514.
KEGGi mbo:Mb1625.
PATRICi 18005253. VBIMycBov88188_1774.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiHISX_MYCBO
AccessioniPrimary (citable) accession number: P63951
Secondary accession number(s): O08396, X2BIB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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