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P63938 (ALDH_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable aldehyde dehydrogenase

EC=1.2.1.3
Gene names
Ordered Locus Names:Mb0467
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Probable aldehyde dehydrogenase
PRO_0000056450

Regions

Nucleotide binding219 – 2257NAD By similarity

Sites

Active site2631 By similarity
Active site3021 By similarity

Sequences

Sequence LengthMass (Da)Tools
P63938 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4AB57CB742244451

FASTA50754,575
        10         20         30         40         50         60 
MTVFSRPGSA GALMSYESRY QNFIGGQWVA PVHGRYFENP TPVTGQPFCE VPRSDAADID 

        70         80         90        100        110        120 
KALDAAHAAA PGWGKTAPAE RAAILNMIAD RIDKNAAALA VAEVWDNGKP VREALAADIP 

       130        140        150        160        170        180 
LAVDHFRYFA AAIRAQEGAL SQIDEDTVAY HFHEPLGVVG QIIPWNFPIL MAAWKLAPAL 

       190        200        210        220        230        240 
AAGNTAVLKP AEQTPASVLY LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SDRIAKVAFT 

       250        260        270        280        290        300 
GETTTGRLIM QYASHNLIPV TLELGGKSPN IFFADVLAAH DDFCDKALEG FTMFALNQGE 

       310        320        330        340        350        360 
VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDTETM LGSQASNDQL EKVLSYIEIG 

       370        380        390        400        410        420 
KQEGAVIIAG GERAELGGDL SGGYYMQPTI FTGTNNMRIF KEEIFGPVVA VTSFTDYDDA 

       430        440        450        460        470        480 
IGIANDTLYG LGAGVWSRDG NTAYRAGRDI QAGRVWVNCY HLYPAHAAFG GYKQSGIGRE 

       490        500 
GHQMMLQHYQ HTKNLLVSYS DKALGFF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO41707.1.
RefSeqNP_854130.1. NC_002945.3.

3D structure databases

ProteinModelPortalP63938.
SMRP63938. Positions 17-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb0467.

Proteomic databases

PRIDEP63938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD93330; CAD93330; Mb0467.
GeneID1091499.
KEGGmbo:Mb0467.
PATRIC18002681. VBIMycBov88188_0509.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00128.
OMAIDENRAA.
OrthoDBEOG6BS8QW.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_MYCBO
AccessionPrimary (citable) accession number: P63938
Secondary accession number(s): O53743, X2BF41
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families