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P63938

- ALDH_MYCBO

UniProt

P63938 - ALDH_MYCBO

Protein

Probable aldehyde dehydrogenase

Gene

Mb0467

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei263 – 2631By similarity
    Active sitei302 – 3021By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi219 – 2257NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Ordered Locus Names:Mb0467
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Probable aldehyde dehydrogenasePRO_0000056450Add
    BLAST

    Proteomic databases

    PRIDEiP63938.

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb0467.

    Structurei

    3D structure databases

    ProteinModelPortaliP63938.
    SMRiP63938. Positions 17-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiIDENRAA.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63938-1 [UniParc]FASTAAdd to Basket

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    MTVFSRPGSA GALMSYESRY QNFIGGQWVA PVHGRYFENP TPVTGQPFCE    50
    VPRSDAADID KALDAAHAAA PGWGKTAPAE RAAILNMIAD RIDKNAAALA 100
    VAEVWDNGKP VREALAADIP LAVDHFRYFA AAIRAQEGAL SQIDEDTVAY 150
    HFHEPLGVVG QIIPWNFPIL MAAWKLAPAL AAGNTAVLKP AEQTPASVLY 200
    LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SDRIAKVAFT GETTTGRLIM 250
    QYASHNLIPV TLELGGKSPN IFFADVLAAH DDFCDKALEG FTMFALNQGE 300
    VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDTETM LGSQASNDQL 350
    EKVLSYIEIG KQEGAVIIAG GERAELGGDL SGGYYMQPTI FTGTNNMRIF 400
    KEEIFGPVVA VTSFTDYDDA IGIANDTLYG LGAGVWSRDG NTAYRAGRDI 450
    QAGRVWVNCY HLYPAHAAFG GYKQSGIGRE GHQMMLQHYQ HTKNLLVSYS 500
    DKALGFF 507
    Length:507
    Mass (Da):54,575
    Last modified:October 11, 2004 - v1
    Checksum:i4AB57CB742244451
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41707.1.
    RefSeqiNP_854130.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD93330; CAD93330; Mb0467.
    GeneIDi1091499.
    KEGGimbo:Mb0467.
    PATRICi18002681. VBIMycBov88188_0509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41707.1 .
    RefSeqi NP_854130.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P63938.
    SMRi P63938. Positions 17-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb0467.

    Proteomic databases

    PRIDEi P63938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD93330 ; CAD93330 ; Mb0467 .
    GeneIDi 1091499.
    KEGGi mbo:Mb0467.
    PATRICi 18002681. VBIMycBov88188_0509.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi IDENRAA.
    OrthoDBi EOG6BS8QW.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiALDH_MYCBO
    AccessioniPrimary (citable) accession number: P63938
    Secondary accession number(s): O53743, X2BF41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3