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Protein

Probable aldehyde dehydrogenase

Gene

Mb0467

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631By similarity
Active sitei302 – 3021By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi219 – 2257NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:Mb0467
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Probable aldehyde dehydrogenasePRO_0000056450Add
BLAST

Proteomic databases

PRIDEiP63938.

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb0467.

Structurei

3D structure databases

ProteinModelPortaliP63938.
SMRiP63938. Positions 21-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00138.
OMAiHLIMEAA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFSRPGSA GALMSYESRY QNFIGGQWVA PVHGRYFENP TPVTGQPFCE
60 70 80 90 100
VPRSDAADID KALDAAHAAA PGWGKTAPAE RAAILNMIAD RIDKNAAALA
110 120 130 140 150
VAEVWDNGKP VREALAADIP LAVDHFRYFA AAIRAQEGAL SQIDEDTVAY
160 170 180 190 200
HFHEPLGVVG QIIPWNFPIL MAAWKLAPAL AAGNTAVLKP AEQTPASVLY
210 220 230 240 250
LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SDRIAKVAFT GETTTGRLIM
260 270 280 290 300
QYASHNLIPV TLELGGKSPN IFFADVLAAH DDFCDKALEG FTMFALNQGE
310 320 330 340 350
VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDTETM LGSQASNDQL
360 370 380 390 400
EKVLSYIEIG KQEGAVIIAG GERAELGGDL SGGYYMQPTI FTGTNNMRIF
410 420 430 440 450
KEEIFGPVVA VTSFTDYDDA IGIANDTLYG LGAGVWSRDG NTAYRAGRDI
460 470 480 490 500
QAGRVWVNCY HLYPAHAAFG GYKQSGIGRE GHQMMLQHYQ HTKNLLVSYS

DKALGFF
Length:507
Mass (Da):54,575
Last modified:October 11, 2004 - v1
Checksum:i4AB57CB742244451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41707.1.
RefSeqiNP_854130.1. NC_002945.3.
WP_003402294.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO41707; CDO41707; Mb0467.
GeneIDi1091499.
KEGGimbo:Mb0467.
PATRICi18002681. VBIMycBov88188_0509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41707.1.
RefSeqiNP_854130.1. NC_002945.3.
WP_003402294.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP63938.
SMRiP63938. Positions 21-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233413.Mb0467.

Proteomic databases

PRIDEiP63938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO41707; CDO41707; Mb0467.
GeneIDi1091499.
KEGGimbo:Mb0467.
PATRICi18002681. VBIMycBov88188_0509.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00138.
OMAiHLIMEAA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiALDH_MYCBO
AccessioniPrimary (citable) accession number: P63938
Secondary accession number(s): O53743, X2BF41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 27, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.