P63937 (ALDH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aldehyde dehydrogenase
EC=1.2.1.3

Gene names

Ordered Locus Names:	Rv0458, MT0474
ORF Names:	MTV038.02

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation by symbiont of host immune response Inferred from direct assay PubMed 21170273. Source: MTBBASE
Cellular_component	plasma membrane Inferred from direct assay PubMed 14532352. Source: MTBBASE
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Probable aldehyde dehydrogenase		PRO_0000056449
Regions
	Nucleotide binding	219 – 225	7	NAD By similarity
Sites
	Active site	263	1	By similarity
	Active site	302	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63937 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4AB57CB742244451	FASTA	507	54,575
	10 20 30 40 50 60 MTVFSRPGSA GALMSYESRY QNFIGGQWVA PVHGRYFENP TPVTGQPFCE VPRSDAADID 70 80 90 100 110 120 KALDAAHAAA PGWGKTAPAE RAAILNMIAD RIDKNAAALA VAEVWDNGKP VREALAADIP 130 140 150 160 170 180 LAVDHFRYFA AAIRAQEGAL SQIDEDTVAY HFHEPLGVVG QIIPWNFPIL MAAWKLAPAL 190 200 210 220 230 240 AAGNTAVLKP AEQTPASVLY LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SDRIAKVAFT 250 260 270 280 290 300 GETTTGRLIM QYASHNLIPV TLELGGKSPN IFFADVLAAH DDFCDKALEG FTMFALNQGE 310 320 330 340 350 360 VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDTETM LGSQASNDQL EKVLSYIEIG 370 380 390 400 410 420 KQEGAVIIAG GERAELGGDL SGGYYMQPTI FTGTNNMRIF KEEIFGPVVA VTSFTDYDDA 430 440 450 460 470 480 IGIANDTLYG LGAGVWSRDG NTAYRAGRDI QAGRVWVNCY HLYPAHAAFG GYKQSGIGRE 490 500 GHQMMLQHYQ HTKNLLVSYS DKALGFF

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842573 Genomic DNA. Translation: CAA17413.1. AE000516 Genomic DNA. Translation: AAK44698.1. AL123456 Genomic DNA. Translation: CCP43191.1.
PIR	F70827.
RefSeq	NP_214972.1. NC_000962.3. NP_334884.1. NC_002755.2. YP_006513787.1. NC_018143.1.
3D structure databases
ProteinModelPortal	P63937.
SMR	P63937. Positions 21-499.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv0458.
PTM databases
PhosSite	P12071664.
Proteomic databases
PRIDE	P63937.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK44698; AAK44698; MT0474.
GeneID	13318328. 886306. 923816.
KEGG	mtc:MT0474. mtu:Rv0458. mtv:RVBD_0458.
PATRIC	18122756. VBIMycTub22151_0512.
Organism-specific databases
TubercuList	Rv0458.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
KO	K00128.
OMA	THKMMLS.
ProtClustDB	CLSK790532.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_MYCTU

Accession

Primary (citable) accession number: P63937
Secondary accession number(s): L0T3T1, O53743

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program