P63929 (DEOC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	Rv0478, MT0496
ORF Names:	MTCY20G9.04

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Miscellaneous	Was identified as a high-confidence drug target. HAMAP MF_00114
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000057248
Sites
	Active site	159	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	189	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63929 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 0D8AD5A926C1DD48	FASTA	224	22,068
	10 20 30 40 50 60 MLGQPTRAQL AALVDHTLLK PETTRADVAA LVAEAAELGV YAVCVSPSMV PVAVQAGGVR 70 80 90 100 110 120 VAAVTGFPSG KHVSSVKAHE AAAALASGAS EIDMVIDIGA ALCGDIDAVR SDIEAVRAAA 130 140 150 160 170 180 AGAVLKVIVE SAVLLGQSNA HTLVDACRAA EDAGADFVKT STGCHPAGGA TVRAVELMAE 190 200 210 220 TVGPRLGVKA SGGIRTAADA VAMLNAGATR LGLSGTRAVL DGLS

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis." Raman K., Yeturu K., Chandra N. BMC Syst. Biol. 2:109-109(2008) [PubMed: 19099550] [Abstract] Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842573 Genomic DNA. Translation: CAB00939.1. AE000516 Genomic DNA. Translation: AAK44719.1.
PIR	A70743.
RefSeq	NP_214992.1. NC_000962.2. NP_334905.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P63929.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000003544; EBMYCP00000003544; EBMYCG00000003542. EBMYCT00000071434; EBMYCP00000069493; EBMYCG00000071429.
GeneID	888425. 923848.
GenomeReviews	Gene locus MT0496 in contig AE000516_GR. Gene locus Rv0478 in contig AL123456_GR.
KEGG	mtc:MT0496. mtu:Rv0478.
PATRIC	18122798. VBIMycTub22151_0533.
TIGR	MT0496.
Organism-specific databases
TubercuList	Rv0478.
Phylogenomic databases
GeneTree	EBGT00050000017372.
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	P63929.
ProtClustDB	PRK00507.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_MYCTU

Accession

Primary (citable) accession number: P63929
Secondary accession number(s): Q11138

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program