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Protein

Phosphopentomutase

Gene

deoB

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotation

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotation
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 or 2 manganese ions.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141ManganeseUniRule annotation
Metal bindingi291 – 2911ManganeseUniRule annotation
Metal bindingi327 – 3271ManganeseUniRule annotation
Metal bindingi328 – 3281ManganeseUniRule annotation
Metal bindingi339 – 3391ManganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-139-MONOMER.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotation (EC:5.4.2.7UniRule annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:deoBUniRule annotation
Synonyms:drm
Ordered Locus Names:SAV0139
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392PhosphopentomutasePRO_0000199840Add
BLAST

Proteomic databases

PaxDbiP63925.

2D gel databases

World-2DPAGE0002:P63925.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0139.

Structurei

3D structure databases

ProteinModelPortaliP63925.
SMRiP63925. Positions 5-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.
PhylomeDBiP63925.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

P63925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPFNRVHL IVMDSVGIGE APDAADFKDE GSHTLRHTLE GFDQTLPNLE
60 70 80 90 100
KLGLGNIDKL PVVNAVEQPE AYYTKLSEAS VGKDTMTGHW EIMGLNIMQP
110 120 130 140 150
FKVYPNGFPE ELIQQIEEMT GRKVVANKPA SGTQIIDEWG EHQMKTGDLI
160 170 180 190 200
VYTSADPVLQ IAAHEDIIPL EELYDICEKV RELTKDPKYL IGRIIARPYV
210 220 230 240 250
GEPGNFTRTS NRHDYALKPF GKTVLDHLKD GGYDVIAIGK INDIYDGEGV
260 270 280 290 300
TEAVRTKSNM DGMDQLMKIV KKDFTGISFL NLVDFDALYG HRRDKPGYAQ
310 320 330 340 350
AIKDFDDRLP ELFSNLKEDD LVIITADHGN DPTAPGTDHT REYIPVIMYS
360 370 380 390
PKFKGGHALE SDTTFSSIGA TIADNFNVTL PEFGKSYLKE LK
Length:392
Mass (Da):43,796
Last modified:October 11, 2004 - v1
Checksum:i6012D71CD9BDB549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56301.1.
RefSeqiWP_000197806.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56301; BAB56301; SAV0139.
KEGGisav:SAV0139.
PATRICi19560879. VBIStaAur52173_0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56301.1.
RefSeqiWP_000197806.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP63925.
SMRiP63925. Positions 5-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0139.

2D gel databases

World-2DPAGE0002:P63925.

Proteomic databases

PaxDbiP63925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56301; BAB56301; SAV0139.
KEGGisav:SAV0139.
PATRICi19560879. VBIStaAur52173_0137.

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.
PhylomeDBiP63925.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciSAUR158878:GJJ5-139-MONOMER.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOB_STAAM
AccessioniPrimary (citable) accession number: P63925
Secondary accession number(s): Q99X76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.