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P63914

- DEF_BRUSU

UniProt

P63914 - DEF_BRUSU

Protein

Peptide deformylase

Gene

def

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941IronUniRule annotation
    Metal bindingi136 – 1361IronUniRule annotation
    Active sitei137 – 1371UniRule annotation
    Metal bindingi140 – 1401IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:BRA1035, BS1330_II1027
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175Peptide deformylasePRO_0000082753Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA1035.

    Structurei

    3D structure databases

    ProteinModelPortaliP63914.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P63914-1 [UniParc]FASTAAdd to Basket

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    MSVKPLIILP DPVLRQVSKP VERFDDQLRK FASDMFDTMY DAPGIGLAAI    50
    QVGEPIRMLV IDLAKEGEPK APHIFVNPTI VQSSDKRSTY EEGCLSIPDY 100
    YAEVERPATV KVNYFDADGK PQSMEADGLM ATCLQHEIDH LNGVLFIDHI 150
    SKLKRDMVIK KFKKLASQRA SKKVL 175
    Length:175
    Mass (Da):19,660
    Last modified:October 11, 2004 - v1
    Checksum:i873A6ABCF3EFFCE2
    GO

    Sequence cautioni

    The sequence AAN34202.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AEM20479.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34202.1. Different initiation.
    CP002998 Genomic DNA. Translation: AEM20479.1. Different initiation.
    RefSeqiNP_700197.1. NC_004311.2.
    YP_005614705.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN34202; AAN34202; BRA1035.
    AEM20479; AEM20479; BS1330_II1027.
    GeneIDi1165480.
    12139260.
    KEGGibms:BRA1035.
    bsi:BS1330_II1027.
    PATRICi17794905. VBIBruSui107850_3260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34202.1 . Different initiation.
    CP002998 Genomic DNA. Translation: AEM20479.1 . Different initiation.
    RefSeqi NP_700197.1. NC_004311.2.
    YP_005614705.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali P63914.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA1035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN34202 ; AAN34202 ; BRA1035 .
    AEM20479 ; AEM20479 ; BS1330_II1027 .
    GeneIDi 1165480.
    12139260.
    KEGGi bms:BRA1035.
    bsi:BS1330_II1027.
    PATRICi 17794905. VBIBruSui107850_3260.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OrthoDBi EOG664CMF.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiDEF_BRUSU
    AccessioniPrimary (citable) accession number: P63914
    Secondary accession number(s): G0KE41, Q8YDB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3