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Protein

Adenosine deaminase

Gene

add

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi21Zinc; catalyticUniRule annotation1
Binding sitei21SubstrateUniRule annotation1
Binding sitei23SubstrateUniRule annotation1
Binding sitei181Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi208Zinc; catalyticUniRule annotation1
Active sitei211Proton donorUniRule annotation1
Sitei232Important for catalytic activityUniRule annotation1
Metal bindingi300Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7588-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:Rv3313c
ORF Names:MTV016.13
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3313c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001943741 – 365Adenosine deaminaseAdd BLAST365

Proteomic databases

PaxDbiP63907.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3313c.

Structurei

3D structure databases

ProteinModelPortaliP63907.
SMRiP63907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
InParanoidiP63907.
KOiK01488.
OMAiDWMVAVL.
PhylomeDBiP63907.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

P63907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAPTLQTI RLAPKALLHD HLDGGLRPAT VLDIAGQVGY DDLPATDVDA
60 70 80 90 100
LASWFRTQSH SGSLERYLEP FSHTVAVMQT PEALYRVAFE CAQDLAADSV
110 120 130 140 150
VYAEVRFAPE LHISCGLSFD DVVDTVLTGF AAGEKACAAD GQPITVRCLV
160 170 180 190 200
TAMRHAAMSR EIAELAIRFR DKGVVGFDIA GAEAGHPPTR HLDAFEYMRD
210 220 230 240 250
HNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI DVDADGGFQL
260 270 280 290 300
GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR ARFRVTVNTD
310 320 330 340 350
NRLMSDTSMS LEMHRLVEAF GYGWSDLARF TVNAMKSAFI PFDQRLAIID
360
EVIKPRFAAL MGHSE
Length:365
Mass (Da):39,743
Last modified:October 11, 2004 - v1
Checksum:iC034CDCEC377BB29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46133.1.
PIRiH70842.
RefSeqiNP_217830.1. NC_000962.3.
WP_003417259.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP46133; CCP46133; Rv3313c.
GeneIDi887994.
KEGGimtu:Rv3313c.
PATRICi18155985. VBIMycTub87468_3703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46133.1.
PIRiH70842.
RefSeqiNP_217830.1. NC_000962.3.
WP_003417259.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliP63907.
SMRiP63907.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3313c.

Proteomic databases

PaxDbiP63907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46133; CCP46133; Rv3313c.
GeneIDi887994.
KEGGimtu:Rv3313c.
PATRICi18155985. VBIMycTub87468_3703.

Organism-specific databases

TubercuListiRv3313c.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
InParanoidiP63907.
KOiK01488.
OMAiDWMVAVL.
PhylomeDBiP63907.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7588-MONOMER.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADD_MYCTU
AccessioniPrimary (citable) accession number: P63907
Secondary accession number(s): L0TCF2, O53365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.