P63901 (DCD_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	c2592

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_0000155985

Sequences

	Sequence		Length	Mass (Da)
	P63901 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E0063139C04A4FC2	FASTA	193	21,251
	10 20 30 40 50 60 MRLCDRDIEA WLDEGRLSIN PRPPVERING ATVDVRLGNK FRTFRGHTAA FIDLSGPKDE 70 80 90 100 110 120 VSAALDRVMS DEIVLDESEA FYLHPGELAL AVTLESVTLP ADLVGWLDGR SSLARLGLMV 130 140 150 160 170 180 HVTAHRIDPG WSGCIVLEFY NSGKLPLALR PGMLIGALSF EPLSGPAARP YNRREDAKYR 190 NQQGAVASRI DKD

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN81048.1.
RefSeq	NP_754480.1. NC_004431.1.
3D structure databases
ProteinModelPortal	P63901.
SMR	P63901. Positions 1-193.
ModBase	Search...
Protein-protein interaction databases
STRING	199310.c2592.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN81048; AAN81048; c2592.
GeneID	1037894.
KEGG	ecc:c2592.
PATRIC	18283056. VBIEscCol75197_2436.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000228601.
KO	K01494.
OMA	RQDAKYK.
ProtClustDB	PRK00416.
Enzyme and pathway databases
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_ECOL6

Accession

Primary (citable) accession number: P63901
Secondary accession number(s): Q8X7L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program