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P63884

- AMIC_ECOL6

UniProt

P63884 - AMIC_ECOL6

Protein

N-acetylmuramoyl-L-alanine amidase AmiC

Gene

amiC

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase AmiC (EC:3.5.1.28)
    Gene namesi
    Name:amiC
    Ordered Locus Names:c3411
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini32 – 417386N-acetylmuramoyl-L-alanine amidase AmiCPRO_0000006466Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c3411.

    Structurei

    3D structure databases

    ProteinModelPortaliP63884.
    SMRiP63884. Positions 35-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000263827.
    KOiK01448.
    OMAiHKNKVDQ.
    OrthoDBiEOG6CP3X3.

    Family and domain databases

    Gene3Di3.40.630.40. 2 hits.
    InterProiIPR021731. AMIN_dom.
    IPR002508. CW_Hdrlase/autolysin_cat.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF01520. Amidase_3. 1 hit.
    PF11741. AMIN. 1 hit.
    [Graphical view]
    SMARTiSM00646. Ami_3. 1 hit.
    [Graphical view]
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63884-1 [UniParc]FASTAAdd to Basket

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    MSGSNTAISR RRLLQGAGAM WLLSVSQVSL AAVSQVVAVR VWPASSYTRV    50
    TVESNRQLKY KQFALSNPER VVVDIEDVNL NSVLKGMAAQ IRADDPFIKS 100
    ARVGQFDPQT VRMVFELKQN VKPQLFALAP VAGFKERLVM DLYPANAQDM 150
    QDPLLALLED YNKGDLEKQV PPAQSGPQPG KAGRDRPIVI MLDPGHGGED 200
    SGAVGKYKTR EKDVVLQIAR RLRSLIEKEG NMKVYMTRNE DIFIPLQVRV 250
    AKAQKQRADL FVSIHADAFT SRQPSGSSVF ALSTKGATST AAKYLAQTQN 300
    ASDLIGGVSK SGDRYVDHTM FDMVQSLTIA DSLKFGKAVL NKLGKINKLH 350
    KNQVEQAGFA VLKAPDIPSI LVETAFISNV EEERKLKTAT FQQEVAESIL 400
    AGIKAYFADG ATLARRG 417
    Length:417
    Mass (Da):45,634
    Last modified:October 11, 2004 - v1
    Checksum:i76F8F733DCCC36D7
    GO

    Sequence cautioni

    The sequence AAN81856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN81856.1. Different initiation.
    RefSeqiNP_755286.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN81856; AAN81856; c3411.
    GeneIDi1039280.
    KEGGiecc:c3411.
    PATRICi18284650. VBIEscCol75197_3211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN81856.1 . Different initiation.
    RefSeqi NP_755286.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P63884.
    SMRi P63884. Positions 35-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c3411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN81856 ; AAN81856 ; c3411 .
    GeneIDi 1039280.
    KEGGi ecc:c3411.
    PATRICi 18284650. VBIEscCol75197_3211.

    Phylogenomic databases

    HOGENOMi HOG000263827.
    KOi K01448.
    OMAi HKNKVDQ.
    OrthoDBi EOG6CP3X3.

    Family and domain databases

    Gene3Di 3.40.630.40. 2 hits.
    InterProi IPR021731. AMIN_dom.
    IPR002508. CW_Hdrlase/autolysin_cat.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF01520. Amidase_3. 1 hit.
    PF11741. AMIN. 1 hit.
    [Graphical view ]
    SMARTi SM00646. Ami_3. 1 hit.
    [Graphical view ]
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiAMIC_ECOL6
    AccessioniPrimary (citable) accession number: P63884
    Secondary accession number(s): Q46929
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3