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P63884

- AMIC_ECOL6

UniProt

P63884 - AMIC_ECOL6

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Protein
N-acetylmuramoyl-L-alanine amidase AmiC
Gene
amiC, c3411
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase AmiC (EC:3.5.1.28)
Gene namesi
Name:amiC
Ordered Locus Names:c3411
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Tat-type signal Reviewed prediction
Add
BLAST
Chaini32 – 417386N-acetylmuramoyl-L-alanine amidase AmiC
PRO_0000006466Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Protein-protein interaction databases

STRINGi199310.c3411.

Structurei

3D structure databases

ProteinModelPortaliP63884.
SMRiP63884. Positions 35-408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000263827.
KOiK01448.
OMAiHKNKVDQ.
OrthoDBiEOG6CP3X3.

Family and domain databases

Gene3Di3.40.630.40. 2 hits.
InterProiIPR021731. AMIN_dom.
IPR002508. CW_Hdrlase/autolysin_cat.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
PF11741. AMIN. 1 hit.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
[Graphical view]
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63884-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSNTAISR RRLLQGAGAM WLLSVSQVSL AAVSQVVAVR VWPASSYTRV    50
TVESNRQLKY KQFALSNPER VVVDIEDVNL NSVLKGMAAQ IRADDPFIKS 100
ARVGQFDPQT VRMVFELKQN VKPQLFALAP VAGFKERLVM DLYPANAQDM 150
QDPLLALLED YNKGDLEKQV PPAQSGPQPG KAGRDRPIVI MLDPGHGGED 200
SGAVGKYKTR EKDVVLQIAR RLRSLIEKEG NMKVYMTRNE DIFIPLQVRV 250
AKAQKQRADL FVSIHADAFT SRQPSGSSVF ALSTKGATST AAKYLAQTQN 300
ASDLIGGVSK SGDRYVDHTM FDMVQSLTIA DSLKFGKAVL NKLGKINKLH 350
KNQVEQAGFA VLKAPDIPSI LVETAFISNV EEERKLKTAT FQQEVAESIL 400
AGIKAYFADG ATLARRG 417
Length:417
Mass (Da):45,634
Last modified:October 11, 2004 - v1
Checksum:i76F8F733DCCC36D7
GO

Sequence cautioni

The sequence AAN81856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN81856.1. Different initiation.
RefSeqiNP_755286.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN81856; AAN81856; c3411.
GeneIDi1039280.
KEGGiecc:c3411.
PATRICi18284650. VBIEscCol75197_3211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN81856.1 . Different initiation.
RefSeqi NP_755286.1. NC_004431.1.

3D structure databases

ProteinModelPortali P63884.
SMRi P63884. Positions 35-408.
ModBasei Search...

Protein-protein interaction databases

STRINGi 199310.c3411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN81856 ; AAN81856 ; c3411 .
GeneIDi 1039280.
KEGGi ecc:c3411.
PATRICi 18284650. VBIEscCol75197_3211.

Phylogenomic databases

HOGENOMi HOG000263827.
KOi K01448.
OMAi HKNKVDQ.
OrthoDBi EOG6CP3X3.

Family and domain databases

Gene3Di 3.40.630.40. 2 hits.
InterProi IPR021731. AMIN_dom.
IPR002508. CW_Hdrlase/autolysin_cat.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF01520. Amidase_3. 1 hit.
PF11741. AMIN. 1 hit.
[Graphical view ]
SMARTi SM00646. Ami_3. 1 hit.
[Graphical view ]
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiAMIC_ECOL6
AccessioniPrimary (citable) accession number: P63884
Secondary accession number(s): Q46929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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