Skip Header

Contribute Send feedback
Read comments (?) or add your own

P63870 (CYSK_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine synthase
Short name=CSase
EC=2.5.1.47
Alternative name(s):
O-acetylserine (thiol)-lyase
Short name=OAS-TL
O-acetylserine sulfhydrylase
Gene names
Name:cysK
Ordered Locus Names:SAV0513
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Cysteine synthase
PRO_0000167096

Regions

Region180 – 1845Pyridoxal phosphate binding By similarity

Sites

Binding site761Pyridoxal phosphate By similarity
Binding site2681Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue461N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63870 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: B881E3E85FF0DBC3

FASTA31032,976
        10         20         30         40         50         60 
MAQKPVDNIT QIIGGTPVVK LRNVVDDNAA DVYVKLEYQN PGGSVKDRIA LAMIEKAERE 

        70         80         90        100        110        120 
GKIKPGDTIV EPTSGNTGIG LAFVCAAKGY KAVFTMPETM SQERRNLLKA YGAELVLTPG 

       130        140        150        160        170        180 
SEAMKGAIKK AKELKEEHGY FEPQQFENPA NPEVHELTTG PELLQQFEGK TIDAFLAGVG 

       190        200        210        220        230        240 
TGGTLSGVGK VLKKEYPNIE IVAIEPEASP VLSGGEPGPH KLQGLGAGFI PGTLNTEIYD 

       250        260        270        280        290        300 
SIIKVGNDTA MEMSRRVAKE EGILAGISSG AAIYAAIQKA KELGKGKTVV TVLPSNGERY 

       310 
LSTPLYSFDD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB56675.1.
RefSeqNP_371037.1. NC_002758.2.

3D structure databases

ProteinModelPortalP63870.
SMRP63870. Positions 4-310.
ModBaseSearch...

Protein-protein interaction databases

STRINGP63870.

2D gel databases

World-2DPAGE0002:P63870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000007412; EBSTAP00000007230; EBSTAG00000007411.
GeneID1120473.
GenomeReviewsGene locus SAV0513 in contig BA000017_GR.
KEGGsav:SAV0513.
PATRIC19561648. VBIStaAur52173_0517.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0031.
GeneTreeEBGT00050000024422.
HOGENOMHBG748215.
OMASAGANIH.
PhylomeDBP63870.
ProtClustDBCLSK884704.

Enzyme and pathway databases

BioCycSAUR158878:SAV0513-MONOMER.

Family and domain databases

InterProIPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]
KOK01738.
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMsTIGR01139. CysK. 1 hit.
TIGR01136. CysKM. 1 hit.
PROSITEPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSK_STAAM
AccessionPrimary (citable) accession number: P63870
Secondary accession number(s): Q99W90
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents