P63856 (COX3_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III

Gene names

Name:	ctaE
Ordered Locus Names:	Rv2193, MT2249
ORF Names:	MTCY190.04

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro growth Inferred from mutant phenotype PubMed 12657046. Source: MTBBASE
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Probable cytochrome c oxidase subunit 3		PRO_0000183884
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P63856 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 70145380A05BD0C2	FASTA	203	22,420
	10 20 30 40 50 60 MTSAVGTSGT AITSRVHSLN RPNMVSVGTI VWLSSELMFF AGLFAFYFSA RAQAGGNWPP 70 80 90 100 110 120 PPTELNLYQA VPVTLVLIAS SFTCQMGVFA AERGDIFGLR RWYVITFLMG LFFVLGQAYE 130 140 150 160 170 180 YRNLMSHGTS IPSSAYGSVF YLATGFHGLH VTGGLIAFIF LLVRTGMSKF TPAQATASIV 190 200 VSYYWHFVDI VWIALFTVIY FIR

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842579 Genomic DNA. Translation: CAA94262.1. AE000516 Genomic DNA. Translation: AAK46535.1. AL123456 Genomic DNA. Translation: CCP44970.1.
PIR	B70784.
RefSeq	NP_216709.1. NC_000962.3. NP_336721.1. NC_002755.2. YP_006515613.1. NC_018143.1.
3D structure databases
ProteinModelPortal	P63856.
SMR	P63856. Positions 28-201.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv2193.
Proteomic databases
PRIDE	P63856.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK46535; AAK46535; MT2249.
GeneID	13318882. 887425. 924177.
KEGG	mtc:MT2249. mtu:Rv2193. mtv:RVBD_2193.
PATRIC	18126700. VBIMycTub22151_2462.
Organism-specific databases
TubercuList	Rv2193.
Phylogenomic databases
eggNOG	COG1845.
HOGENOM	HOG000086399.
KO	K02276.
OMA	GDWPPEP.
ProtClustDB	CLSK872023.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_MYCTU

Accession

Primary (citable) accession number: P63856
Secondary accession number(s): L0T941, Q10385

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program