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P63855 (COX2_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Ordered Locus Names:Mb2223c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential
Chain42 – 363322Cytochrome c oxidase subunit 2
PRO_0000006055

Regions

Transmembrane71 – 9121Helical; Potential
Transmembrane118 – 13821Helical; Potential

Sites

Metal binding2541Copper A Potential
Metal binding2951Copper A Potential
Metal binding2991Copper A Potential
Metal binding3031Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
P63855 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9EAC7F0FE6EE5779

FASTA36340,480
        10         20         30         40         50         60 
MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS EALGIGWPEG 

        70         80         90        100        110        120 
ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK NTDTELPRQF GYNMPLELVL 

       130        140        150        160        170        180 
TVIPFLIISV LFYFTVVVQE KMLQIAKDPE VVIDITSFQW NWKFGYQRVN FKDGTLTYDG 

       190        200        210        220        230        240 
ADPERKRAMV SKPEGKDKYG EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG 

       250        260        270        280        290        300 
KRIEFQMASA DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG 

       310        320        330        340        350        360 
TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF DTRRGELAPQ 


PVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO43477.1.
RefSeqNP_855872.1. NC_002945.3.

3D structure databases

ProteinModelPortalP63855.
SMRP63855. Positions 72-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb2223c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD97076; CAD97076; Mb2223c.
GeneID1091345.
KEGGmbo:Mb2223c.
PATRIC18006586. VBIMycBov88188_2439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000245527.
KOK02275.
OMAMRELWTW.
OrthoDBEOG68SVXT.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYCBO
AccessionPrimary (citable) accession number: P63855
Secondary accession number(s): Q10375, X2BJL3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families