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P63855

- COX2_MYCBO

UniProt

P63855 - COX2_MYCBO

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi254 – 2541Copper ASequence Analysis
    Metal bindingi295 – 2951Copper ASequence Analysis
    Metal bindingi299 – 2991Copper ASequence Analysis
    Metal bindingi303 – 3031Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:ctaC
    Ordered Locus Names:Mb2223c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 363322Cytochrome c oxidase subunit 2PRO_0000006055Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb2223c.

    Structurei

    3D structure databases

    ProteinModelPortaliP63855.
    SMRiP63855. Positions 72-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000245527.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63855-1 [UniParc]FASTAAdd to Basket

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    MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS    50
    EALGIGWPEG ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK 100
    NTDTELPRQF GYNMPLELVL TVIPFLIISV LFYFTVVVQE KMLQIAKDPE 150
    VVIDITSFQW NWKFGYQRVN FKDGTLTYDG ADPERKRAMV SKPEGKDKYG 200
    EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG KRIEFQMASA 250
    DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG 300
    TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF 350
    DTRRGELAPQ PVG 363
    Length:363
    Mass (Da):40,480
    Last modified:October 11, 2004 - v1
    Checksum:i9EAC7F0FE6EE5779
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43477.1.
    RefSeqiNP_855872.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD97076; CAD97076; Mb2223c.
    GeneIDi1091345.
    KEGGimbo:Mb2223c.
    PATRICi18006586. VBIMycBov88188_2439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43477.1 .
    RefSeqi NP_855872.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P63855.
    SMRi P63855. Positions 72-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2223c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD97076 ; CAD97076 ; Mb2223c .
    GeneIDi 1091345.
    KEGGi mbo:Mb2223c.
    PATRICi 18006586. VBIMycBov88188_2439.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000245527.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiCOX2_MYCBO
    AccessioniPrimary (citable) accession number: P63855
    Secondary accession number(s): Q10375, X2BJL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3