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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi254Copper ASequence analysis1
Metal bindingi295Copper ASequence analysis1
Metal bindingi299Copper ASequence analysis1
Metal bindingi303Copper ASequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-2291-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:BQ2027_MB2223C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000000605542 – 363Cytochrome c oxidase subunit 2Add BLAST322

Structurei

3D structure databases

ProteinModelPortaliP63855
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000245527
OMAiHAFMPIA

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 2 hits
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS
60 70 80 90 100
EALGIGWPEG ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK
110 120 130 140 150
NTDTELPRQF GYNMPLELVL TVIPFLIISV LFYFTVVVQE KMLQIAKDPE
160 170 180 190 200
VVIDITSFQW NWKFGYQRVN FKDGTLTYDG ADPERKRAMV SKPEGKDKYG
210 220 230 240 250
EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG KRIEFQMASA
260 270 280 290 300
DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG
310 320 330 340 350
TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF
360
DTRRGELAPQ PVG
Length:363
Mass (Da):40,480
Last modified:October 11, 2004 - v1
Checksum:i9EAC7F0FE6EE5779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00831.1
RefSeqiNP_855872.1, NC_002945.3
WP_003899214.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO43477; CDO43477; Mb2223c
PATRICifig|233413.5.peg.2439

Similar proteinsi

Entry informationi

Entry nameiCOX2_MYCBO
AccessioniPrimary (citable) accession number: P63855
Secondary accession number(s): A0A1R3Y0H0, Q10375, X2BJL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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