P63855 (COX2_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II

Gene names

Name:	ctaC
Ordered Locus Names:	Mb2223c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity. Heme group By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 363	322	Cytochrome c oxidase subunit 2		PRO_0000006055
Regions
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	118 – 138	21	Helical; Potential
Sites
	Metal binding	254	1	Copper A Potential
	Metal binding	295	1	Copper A Potential
	Metal binding	299	1	Copper A Potential
	Metal binding	303	1	Copper A Potential

Sequences

	Sequence		Length	Mass (Da)
	P63855 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 9EAC7F0FE6EE5779	FASTA	363	40,480
	10 20 30 40 50 60 MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS EALGIGWPEG 70 80 90 100 110 120 ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK NTDTELPRQF GYNMPLELVL 130 140 150 160 170 180 TVIPFLIISV LFYFTVVVQE KMLQIAKDPE VVIDITSFQW NWKFGYQRVN FKDGTLTYDG 190 200 210 220 230 240 ADPERKRAMV SKPEGKDKYG EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG 250 260 270 280 290 300 KRIEFQMASA DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG 310 320 330 340 350 360 TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF DTRRGELAPQ PVG

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248341 Genomic DNA. Translation: CAD97076.1.
RefSeq	NP_855872.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P63855.
SMR	P63855. Positions 72-324.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb2223c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD97076; CAD97076; Mb2223c.
GeneID	1091345.
KEGG	mbo:Mb2223c.
PATRIC	18006586. VBIMycBov88188_2439.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000245527.
KO	K02275.
OMA	MRELWTW.
ProtClustDB	CLSK791696.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_MYCBO

Accession

Primary (citable) accession number: P63855
Secondary accession number(s): Q10375

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program