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P63854 (COX2_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Mtb92
Gene names
Name:ctaC
Ordered Locus Names:Rv2200c, MT2256
ORF Names:MTCY190.11c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Miscellaneous

Was identified as a high-confidence drug target.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence caution

The sequence AAB69853.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential
Chain42 – 363322Cytochrome c oxidase subunit 2
PRO_0000006058

Regions

Transmembrane71 – 9121Helical; Potential
Transmembrane118 – 13821Helical; Potential

Sites

Metal binding2541Copper A Potential
Metal binding2951Copper A Potential
Metal binding2991Copper A Potential
Metal binding3031Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
P63854 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9EAC7F0FE6EE5779

FASTA36340,480
        10         20         30         40         50         60 
MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS EALGIGWPEG 

        70         80         90        100        110        120 
ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK NTDTELPRQF GYNMPLELVL 

       130        140        150        160        170        180 
TVIPFLIISV LFYFTVVVQE KMLQIAKDPE VVIDITSFQW NWKFGYQRVN FKDGTLTYDG 

       190        200        210        220        230        240 
ADPERKRAMV SKPEGKDKYG EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG 

       250        260        270        280        290        300 
KRIEFQMASA DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG 

       310        320        330        340        350        360 
TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF DTRRGELAPQ 


PVG

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors."
Moran A.J., Doran J.L., Wu J., Treit J.D., Ekpo P., Kerr V.J., Roberts A.D., Orme I.M., Galant S., Ress S.R., Nano F.E.
FEMS Microbiol. Lett. 177:123-130(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[3]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[4]"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis."
Raman K., Yeturu K., Chandra N.
BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF009357 Genomic DNA. Translation: AAB69853.1. Different initiation.
BX842579 Genomic DNA. Translation: CAA94269.1.
AE000516 Genomic DNA. Translation: AAK46542.1.
AL123456 Genomic DNA. Translation: CCP44977.1.
PIRA70785.
RefSeqNP_216716.1. NC_000962.3.
NP_336728.1. NC_002755.2.
YP_006515620.1. NC_018143.1.

3D structure databases

ProteinModelPortalP63854.
SMRP63854. Positions 72-324.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2200c.

Proteomic databases

PRIDEP63854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46542; AAK46542; MT2256.
GeneID13318889.
888799.
924170.
KEGGmtc:MT2256.
mtu:Rv2200c.
mtv:RVBD_2200c.
PATRIC18126714. VBIMycTub22151_2469.

Organism-specific databases

TubercuListRv2200c.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000245527.
KOK02275.
OMAMRELWTW.
ProtClustDBCLSK791696.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYCTU
AccessionPrimary (citable) accession number: P63854
Secondary accession number(s): L0TBL3, O30514, Q10375
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents