Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P63853 (COX1_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Ordered Locus Names:Mb3069c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Probable cytochrome c oxidase subunit 1
PRO_0000183444

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane359 – 37921Helical; Potential
Transmembrane398 – 41821Helical; Potential
Transmembrane433 – 45321Helical; Potential
Transmembrane476 – 49621Helical; Potential

Sites

Metal binding861Iron (heme A axial ligand) Probable
Metal binding2641Copper B Probable
Metal binding2681Copper B Probable
Metal binding3131Copper B Probable
Metal binding3141Copper B Probable
Metal binding3971Iron (heme A3 axial ligand) Probable
Metal binding3991Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P63853 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9B0F91666F482BEE

FASTA57363,673
        10         20         30         40         50         60 
MTAEAPPLGE LEAIRPYPAR TGPKGSLVYK LITTTDHKMI GIMYCVACIS FFFIGGLLAL 

        70         80         90        100        110        120 
LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLFYATPIVF GFANLVLPLQ IGAPDVAFPR 

       130        140        150        160        170        180 
LNAFSFWLFV FGATIGAAGF ITPGGAADFG WTAYTPLTDA IHSPGAGGDL WIMGLIVAGL 

       190        200        210        220        230        240 
GTILGAVNMI TTVVCMRAPG MTMFRMPIFT WNIMVTSILI LIAFPLLTAA LFGLAADRHL 

       250        260        270        280        290        300 
GAHIYDAANG GVLLWQHLFW FFGHPEVYII ALPFFGIVSE IFPVFSRKPI FGYTTLVYAT 

       310        320        330        340        350        360 
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK GQLTFETPML 

       370        380        390        400        410        420 
FSVGFMVTFL LGGLTGVLLA SPPLDFHVTD SYFVVAHFHY VLFGTIVFAT FAGIYFWFPK 

       430        440        450        460        470        480 
MTGRLLDERL GKLHFWLTFI GFHTTFLVQH WLGDEGMPRR YADYLPTDGF QGLNVVSTIG 

       490        500        510        520        530        540 
AFILGASMFP FVWNVFKSWR YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER 

       550        560        570 
PAFELHYPHM VERLRAEAHV GRHHDEPAMV TSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO44338.1.
RefSeqNP_856714.1. NC_002945.3.

3D structure databases

ProteinModelPortalP63853.
SMRP63853. Positions 26-544.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3069c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD96756; CAD96756; Mb3069c.
GeneID1093667.
KEGGmbo:Mb3069c.
PATRIC18008482. VBIMycBov88188_3371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085275.
KOK02274.
OMAILNIWIL.
OrthoDBEOG6B35XR.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_MYCBO
AccessionPrimary (citable) accession number: P63853
Secondary accession number(s): O53290, X2BMH9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways