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P63853

- COX1_MYCBO

UniProt

P63853 - COX1_MYCBO

Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Iron (heme A axial ligand)Curated
    Metal bindingi264 – 2641Copper BCurated
    Metal bindingi268 – 2681Copper BCurated
    Metal bindingi313 – 3131Copper BCurated
    Metal bindingi314 – 3141Copper BCurated
    Metal bindingi397 – 3971Iron (heme A3 axial ligand)Curated
    Metal bindingi399 – 3991Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    Ordered Locus Names:Mb3069c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Probable cytochrome c oxidase subunit 1PRO_0000183444Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb3069c.

    Structurei

    3D structure databases

    ProteinModelPortaliP63853.
    SMRiP63853. Positions 26-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei476 – 49621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085275.
    KOiK02274.
    OMAiILNIWIL.
    OrthoDBiEOG6B35XR.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63853-1 [UniParc]FASTAAdd to Basket

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    MTAEAPPLGE LEAIRPYPAR TGPKGSLVYK LITTTDHKMI GIMYCVACIS    50
    FFFIGGLLAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLFYATPIVF 100
    GFANLVLPLQ IGAPDVAFPR LNAFSFWLFV FGATIGAAGF ITPGGAADFG 150
    WTAYTPLTDA IHSPGAGGDL WIMGLIVAGL GTILGAVNMI TTVVCMRAPG 200
    MTMFRMPIFT WNIMVTSILI LIAFPLLTAA LFGLAADRHL GAHIYDAANG 250
    GVLLWQHLFW FFGHPEVYII ALPFFGIVSE IFPVFSRKPI FGYTTLVYAT 300
    LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK 350
    GQLTFETPML FSVGFMVTFL LGGLTGVLLA SPPLDFHVTD SYFVVAHFHY 400
    VLFGTIVFAT FAGIYFWFPK MTGRLLDERL GKLHFWLTFI GFHTTFLVQH 450
    WLGDEGMPRR YADYLPTDGF QGLNVVSTIG AFILGASMFP FVWNVFKSWR 500
    YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM 550
    VERLRAEAHV GRHHDEPAMV TSS 573
    Length:573
    Mass (Da):63,673
    Last modified:October 11, 2004 - v1
    Checksum:i9B0F91666F482BEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44338.1.
    RefSeqiNP_856714.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96756; CAD96756; Mb3069c.
    GeneIDi1093667.
    KEGGimbo:Mb3069c.
    PATRICi18008482. VBIMycBov88188_3371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44338.1 .
    RefSeqi NP_856714.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P63853.
    SMRi P63853. Positions 26-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3069c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96756 ; CAD96756 ; Mb3069c .
    GeneIDi 1093667.
    KEGGi mbo:Mb3069c.
    PATRICi 18008482. VBIMycBov88188_3371.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085275.
    KOi K02274.
    OMAi ILNIWIL.
    OrthoDBi EOG6B35XR.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiCOX1_MYCBO
    AccessioniPrimary (citable) accession number: P63853
    Secondary accession number(s): O53290, X2BMH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3