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P63853

- COX1_MYCBO

UniProt

P63853 - COX1_MYCBO

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Protein
Probable cytochrome c oxidase subunit 1
Gene
ctaD, Mb3069c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron (heme A axial ligand) Inferred
Metal bindingi264 – 2641Copper B Inferred
Metal bindingi268 – 2681Copper B Inferred
Metal bindingi313 – 3131Copper B Inferred
Metal bindingi314 – 3141Copper B Inferred
Metal bindingi397 – 3971Iron (heme A3 axial ligand) Inferred
Metal bindingi399 – 3991Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:Mb3069c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST
Transmembranei359 – 37921Helical; Reviewed prediction
Add
BLAST
Transmembranei398 – 41821Helical; Reviewed prediction
Add
BLAST
Transmembranei433 – 45321Helical; Reviewed prediction
Add
BLAST
Transmembranei476 – 49621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Probable cytochrome c oxidase subunit 1
PRO_0000183444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb3069c.

Structurei

3D structure databases

ProteinModelPortaliP63853.
SMRiP63853. Positions 26-544.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02274.
OMAiILNIWIL.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63853-1 [UniParc]FASTAAdd to Basket

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MTAEAPPLGE LEAIRPYPAR TGPKGSLVYK LITTTDHKMI GIMYCVACIS    50
FFFIGGLLAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLFYATPIVF 100
GFANLVLPLQ IGAPDVAFPR LNAFSFWLFV FGATIGAAGF ITPGGAADFG 150
WTAYTPLTDA IHSPGAGGDL WIMGLIVAGL GTILGAVNMI TTVVCMRAPG 200
MTMFRMPIFT WNIMVTSILI LIAFPLLTAA LFGLAADRHL GAHIYDAANG 250
GVLLWQHLFW FFGHPEVYII ALPFFGIVSE IFPVFSRKPI FGYTTLVYAT 300
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK 350
GQLTFETPML FSVGFMVTFL LGGLTGVLLA SPPLDFHVTD SYFVVAHFHY 400
VLFGTIVFAT FAGIYFWFPK MTGRLLDERL GKLHFWLTFI GFHTTFLVQH 450
WLGDEGMPRR YADYLPTDGF QGLNVVSTIG AFILGASMFP FVWNVFKSWR 500
YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM 550
VERLRAEAHV GRHHDEPAMV TSS 573
Length:573
Mass (Da):63,673
Last modified:October 11, 2004 - v1
Checksum:i9B0F91666F482BEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44338.1.
RefSeqiNP_856714.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96756; CAD96756; Mb3069c.
GeneIDi1093667.
KEGGimbo:Mb3069c.
PATRICi18008482. VBIMycBov88188_3371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44338.1 .
RefSeqi NP_856714.1. NC_002945.3.

3D structure databases

ProteinModelPortali P63853.
SMRi P63853. Positions 26-544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3069c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96756 ; CAD96756 ; Mb3069c .
GeneIDi 1093667.
KEGGi mbo:Mb3069c.
PATRICi 18008482. VBIMycBov88188_3371.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02274.
OMAi ILNIWIL.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiCOX1_MYCBO
AccessioniPrimary (citable) accession number: P63853
Secondary accession number(s): O53290, X2BMH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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