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P63851

- HEM6_BRUSU

UniProt

P63851 - HEM6_BRUSU

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Protein

Oxygen-dependent coproporphyrinogen-III oxidase

Gene

hemF

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.UniRule annotation

Catalytic activityi

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.UniRule annotation

Cofactori

Divalent cations.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateUniRule annotation
Metal bindingi120 – 1201Divalent cationUniRule annotation
Active sitei130 – 1301Proton donorUniRule annotation
Metal bindingi130 – 1301Divalent cationUniRule annotation
Metal bindingi168 – 1681Divalent cationUniRule annotation
Metal bindingi199 – 1991Divalent cationUniRule annotation
Sitei199 – 1991Important for dimerizationUniRule annotation

GO - Molecular functioni

  1. coproporphyrinogen oxidase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00251; UER00322.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent coproporphyrinogen-III oxidaseUniRule annotation (EC:1.3.3.3UniRule annotation)
Short name:
CPOUniRule annotation
Short name:
Coprogen oxidaseUniRule annotation
Short name:
CoproporphyrinogenaseUniRule annotation
Gene namesi
Name:hemFUniRule annotation
Ordered Locus Names:BR1550, BS1330_I1544
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Oxygen-dependent coproporphyrinogen-III oxidasePRO_0000109888Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR1550.

Structurei

3D structure databases

ProteinModelPortaliP63851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1343Substrate bindingUniRule annotation
Regioni268 – 30336Important for dimerizationUniRule annotationAdd
BLAST
Regioni286 – 2883Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the aerobic coproporphyrinogen-III oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0408.
HOGENOMiHOG000262768.
KOiK00228.
OMAiEVYPRYK.
OrthoDBiEOG67T5GJ.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
HAMAPiMF_00333. Coprogen_oxidas.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63851-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKREDIPAII PADIEEKKKA AQSWFEELRD RICASYEQLE DELQGPLSDR
60 70 80 90 100
EPGRFVRTPW QKDDGNGGGV MSIMHGRVFE KVGVHVSTVH GEFSPEFRKQ
110 120 130 140 150
IPGAEEDPRY WASGISLIAH PQNPNVPAVH MNTRMIVTTR QWFAGGADLT
160 170 180 190 200
PVLDRRRTQE DPDTLAFHKA FRFICEKHKD IVDYQRLKEW CDEYFFLPHR
210 220 230 240 250
DEPRGIGGIF YDWLHSPEEK GGWDSDFAFT RDVGRGFSVV YPHLVRQNFN
260 270 280 290 300
KDWTEADRDE QLIRRGRYVE FNLLYDRGTI FGLKTGGNMN AILSSMPPVV

KWP
Length:303
Mass (Da):35,111
Last modified:October 11, 2004 - v1
Checksum:i65C4C1B754D13CE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30457.1.
CP002997 Genomic DNA. Translation: AEM18873.1.
RefSeqiNP_698542.1. NC_004310.3.
YP_005616365.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30457; AAN30457; BR1550.
AEM18873; AEM18873; BS1330_I1544.
GeneIDi1167233.
12137304.
KEGGibms:BR1550.
bsi:BS1330_I1544.
PATRICi17791465. VBIBruSui107850_1577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30457.1 .
CP002997 Genomic DNA. Translation: AEM18873.1 .
RefSeqi NP_698542.1. NC_004310.3.
YP_005616365.1. NC_017251.1.

3D structure databases

ProteinModelPortali P63851.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30457 ; AAN30457 ; BR1550 .
AEM18873 ; AEM18873 ; BS1330_I1544 .
GeneIDi 1167233.
12137304.
KEGGi bms:BR1550.
bsi:BS1330_I1544.
PATRICi 17791465. VBIBruSui107850_1577.

Phylogenomic databases

eggNOGi COG0408.
HOGENOMi HOG000262768.
KOi K00228.
OMAi EVYPRYK.
OrthoDBi EOG67T5GJ.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00322 .

Family and domain databases

Gene3Di 3.40.1500.10. 1 hit.
HAMAPi MF_00333. Coprogen_oxidas.
InterProi IPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view ]
PANTHERi PTHR10755. PTHR10755. 1 hit.
Pfami PF01218. Coprogen_oxidas. 1 hit.
[Graphical view ]
PIRSFi PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSi PR00073. COPRGNOXDASE.
SUPFAMi SSF102886. SSF102886. 1 hit.
PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiHEM6_BRUSU
AccessioniPrimary (citable) accession number: P63851
Secondary accession number(s): G0KC31, Q8YIH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3