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P63851

- HEM6_BRUSU

UniProt

P63851 - HEM6_BRUSU

Protein

Oxygen-dependent coproporphyrinogen-III oxidase

Gene

hemF

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.UniRule annotation

    Catalytic activityi

    Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.UniRule annotation

    Cofactori

    Divalent cations.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateUniRule annotation
    Metal bindingi120 – 1201Divalent cationUniRule annotation
    Active sitei130 – 1301Proton donorUniRule annotation
    Metal bindingi130 – 1301Divalent cationUniRule annotation
    Metal bindingi168 – 1681Divalent cationUniRule annotation
    Metal bindingi199 – 1991Divalent cationUniRule annotation
    Sitei199 – 1991Important for dimerizationUniRule annotation

    GO - Molecular functioni

    1. coproporphyrinogen oxidase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00322.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent coproporphyrinogen-III oxidaseUniRule annotation (EC:1.3.3.3UniRule annotation)
    Short name:
    CPOUniRule annotation
    Short name:
    Coprogen oxidaseUniRule annotation
    Short name:
    CoproporphyrinogenaseUniRule annotation
    Gene namesi
    Name:hemFUniRule annotation
    Ordered Locus Names:BR1550, BS1330_I1544
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Oxygen-dependent coproporphyrinogen-III oxidasePRO_0000109888Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1550.

    Structurei

    3D structure databases

    ProteinModelPortaliP63851.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1343Substrate bindingUniRule annotation
    Regioni268 – 30336Important for dimerizationUniRule annotationAdd
    BLAST
    Regioni286 – 2883Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the aerobic coproporphyrinogen-III oxidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0408.
    HOGENOMiHOG000262768.
    KOiK00228.
    OMAiEVYPRYK.
    OrthoDBiEOG67T5GJ.

    Family and domain databases

    Gene3Di3.40.1500.10. 1 hit.
    HAMAPiMF_00333. Coprogen_oxidas.
    InterProiIPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view]
    PANTHERiPTHR10755. PTHR10755. 1 hit.
    PfamiPF01218. Coprogen_oxidas. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
    PRINTSiPR00073. COPRGNOXDASE.
    SUPFAMiSSF102886. SSF102886. 1 hit.
    PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63851-1 [UniParc]FASTAAdd to Basket

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    MKREDIPAII PADIEEKKKA AQSWFEELRD RICASYEQLE DELQGPLSDR    50
    EPGRFVRTPW QKDDGNGGGV MSIMHGRVFE KVGVHVSTVH GEFSPEFRKQ 100
    IPGAEEDPRY WASGISLIAH PQNPNVPAVH MNTRMIVTTR QWFAGGADLT 150
    PVLDRRRTQE DPDTLAFHKA FRFICEKHKD IVDYQRLKEW CDEYFFLPHR 200
    DEPRGIGGIF YDWLHSPEEK GGWDSDFAFT RDVGRGFSVV YPHLVRQNFN 250
    KDWTEADRDE QLIRRGRYVE FNLLYDRGTI FGLKTGGNMN AILSSMPPVV 300
    KWP 303
    Length:303
    Mass (Da):35,111
    Last modified:October 11, 2004 - v1
    Checksum:i65C4C1B754D13CE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30457.1.
    CP002997 Genomic DNA. Translation: AEM18873.1.
    RefSeqiNP_698542.1. NC_004310.3.
    YP_005616365.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30457; AAN30457; BR1550.
    AEM18873; AEM18873; BS1330_I1544.
    GeneIDi1167233.
    12137304.
    KEGGibms:BR1550.
    bsi:BS1330_I1544.
    PATRICi17791465. VBIBruSui107850_1577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30457.1 .
    CP002997 Genomic DNA. Translation: AEM18873.1 .
    RefSeqi NP_698542.1. NC_004310.3.
    YP_005616365.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali P63851.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30457 ; AAN30457 ; BR1550 .
    AEM18873 ; AEM18873 ; BS1330_I1544 .
    GeneIDi 1167233.
    12137304.
    KEGGi bms:BR1550.
    bsi:BS1330_I1544.
    PATRICi 17791465. VBIBruSui107850_1577.

    Phylogenomic databases

    eggNOGi COG0408.
    HOGENOMi HOG000262768.
    KOi K00228.
    OMAi EVYPRYK.
    OrthoDBi EOG67T5GJ.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00322 .

    Family and domain databases

    Gene3Di 3.40.1500.10. 1 hit.
    HAMAPi MF_00333. Coprogen_oxidas.
    InterProi IPR001260. Coprogen_oxidase_aer.
    IPR018375. Coprogen_oxidase_CS.
    [Graphical view ]
    PANTHERi PTHR10755. PTHR10755. 1 hit.
    Pfami PF01218. Coprogen_oxidas. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000166. Coproporphyri_ox. 1 hit.
    PRINTSi PR00073. COPRGNOXDASE.
    SUPFAMi SSF102886. SSF102886. 1 hit.
    PROSITEi PS01021. COPROGEN_OXIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiHEM6_BRUSU
    AccessioniPrimary (citable) accession number: P63851
    Secondary accession number(s): G0KC31, Q8YIH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3