Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1716-MONOMER
UniPathwayiUPA00241; UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:BQ2027_MB1657
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001729651 – 407Dephospho-CoA kinaseAdd BLAST407

Proteomic databases

PRIDEiP63827

Structurei

3D structure databases

ProteinModelPortaliP63827
SMRiP63827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 204DPCKAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 407UPF0157Add BLAST212

Sequence similaritiesi

In the N-terminal section; belongs to the CoaE family.Curated
In the C-terminal section; belongs to the UPF0157 (GrpB) family.Curated

Phylogenomic databases

HOGENOMiHOG000020768
OMAiIRVDGWP

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR007344 GrpB/CoaE
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
PF04229 GrpB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

P63827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIGLTGGI GAGKSLLSTT FSQCGGIVVD GDVLAREVVQ PGTEGLASLV
60 70 80 90 100
DAFGRDILLA DGALDRQALA AKAFRDDESR GVLNGIVHPL VARRRSEIIA
110 120 130 140 150
AVSGDAVVVE DIPLLVESGM APLFPLVVVV HADVELRVRR LVEQRGMAEA
160 170 180 190 200
DARARIAAQA SDQQRRAVAD VWLDNSGSPE DLVRRARDVW NTRVQPFAHN
210 220 230 240 250
LAQRQIARAP ARLVPADPSW PDQARRIVNR LKIACGHKAL RVDHIGSTAV
260 270 280 290 300
SGFPDFLAKD VIDIQVTVES LDVADELAEP LLAAGYPRLE HITQDTEKTD
310 320 330 340 350
ARSTVGRYDH TDSAALWHKR VHASADPGRP TNVHLRVHGW PNQQFALLFV
360 370 380 390 400
DWLAANPGAR EDYLTVKCDA DRRADGELAR YVTAKEPWFL DAYQRAWEWA

DAVHWRP
Length:407
Mass (Da):44,669
Last modified:October 11, 2004 - v1
Checksum:i166F7A3052943DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00261.1
RefSeqiNP_855310.1, NC_002945.3
WP_003408069.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42906; CDO42906; Mb1657
PATRICifig|233413.5.peg.1808

Similar proteinsi

Entry informationi

Entry nameiCOAE_MYCBO
AccessioniPrimary (citable) accession number: P63827
Secondary accession number(s): A0A1R3XYU3, O06148, X2BIH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health