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P63825 (COAE_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dephospho-CoA kinase

EC=2.7.1.24
Alternative name(s):
Dephosphocoenzyme A kinase
Gene names
Name:coaE
Ordered Locus Names:BR2070, BS1330_I2064
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376

Catalytic activity

ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00376.

Sequence similarities

Belongs to the CoaE family.

Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

dephospho-CoA kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Dephospho-CoA kinase HAMAP-Rule MF_00376
PRO_0000172918

Regions

Domain3 – 200198DPCK
Nucleotide binding8 – 158ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P63825 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: B2CE67FF86C8430D

FASTA20021,441
        10         20         30         40         50         60 
MIVLGLTGSI GMGKTTAAGM FAEAGVPVYS ADDAVHRLYS GRAAPLIEAT FPGTVENGIV 

        70         80         90        100        110        120 
NREKLFKAVI GQPEAIKKLE AVVHPLVREE EDAFRREAEK SGAAIALVDI PLLFETGAEK 

       130        140        150        160        170        180 
RVDKVVVVSA PADIQHTRVL ARPGMTQEKL KAILVRQIPD AEKRSRADFV LDTSGSFDDL 

       190        200 
RRQIAEIITG LSGKPAAATR 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30960.1.
CP002997 Genomic DNA. Translation: AEM19377.1.
RefSeqNP_699045.1. NC_004310.3.
YP_005616869.1. NC_017251.1.

3D structure databases

ProteinModelPortalP63825.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR2070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30960; AAN30960; BR2070.
AEM19377; AEM19377; BS1330_I2064.
GeneID1167773.
12137853.
KEGGbms:BR2070.
bsi:BS1330_I2064.
PATRIC17792569. VBIBruSui107850_2105.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0237.
HOGENOMHOG000020768.
KOK00859.
OMATQGKHNG.
OrthoDBEOG6HTP3H.

Enzyme and pathway databases

UniPathwayUPA00241; UER00356.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00376. Dephospho_CoA_kinase.
InterProIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00152. TIGR00152. 1 hit.
PROSITEPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOAE_BRUSU
AccessionPrimary (citable) accession number: P63825
Secondary accession number(s): G0K918, Q8YE21
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names