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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:BR2070, BS1330_I2064
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Dephospho-CoA kinasePRO_0000172918Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR2070.

Structurei

3D structure databases

ProteinModelPortaliP63825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 200198DPCKUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020768.
KOiK00859.
OMAiMILSRQT.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63825-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLGLTGSI GMGKTTAAGM FAEAGVPVYS ADDAVHRLYS GRAAPLIEAT
60 70 80 90 100
FPGTVENGIV NREKLFKAVI GQPEAIKKLE AVVHPLVREE EDAFRREAEK
110 120 130 140 150
SGAAIALVDI PLLFETGAEK RVDKVVVVSA PADIQHTRVL ARPGMTQEKL
160 170 180 190 200
KAILVRQIPD AEKRSRADFV LDTSGSFDDL RRQIAEIITG LSGKPAAATR
Length:200
Mass (Da):21,441
Last modified:October 11, 2004 - v1
Checksum:iB2CE67FF86C8430D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30960.1.
CP002997 Genomic DNA. Translation: AEM19377.1.
RefSeqiNP_699045.1. NC_004310.3.
YP_005616869.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30960; AAN30960; BR2070.
AEM19377; AEM19377; BS1330_I2064.
GeneIDi1167773.
12137853.
KEGGibms:BR2070.
bsi:BS1330_I2064.
PATRICi17792569. VBIBruSui107850_2105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30960.1.
CP002997 Genomic DNA. Translation: AEM19377.1.
RefSeqiNP_699045.1. NC_004310.3.
YP_005616869.1. NC_017251.1.

3D structure databases

ProteinModelPortaliP63825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR2070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30960; AAN30960; BR2070.
AEM19377; AEM19377; BS1330_I2064.
GeneIDi1167773.
12137853.
KEGGibms:BR2070.
bsi:BS1330_I2064.
PATRICi17792569. VBIBruSui107850_2105.

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020768.
KOiK00859.
OMAiMILSRQT.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiCOAE_BRUSU
AccessioniPrimary (citable) accession number: P63825
Secondary accession number(s): G0K918, Q8YE21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.