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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type II pantothenate kinase (coaW)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
Ordered Locus Names:MW1007
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001562761 – 160Phosphopantetheine adenylyltransferaseAdd BLAST160

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi17 – 26Combined sources10
Helixi27 – 29Combined sources3
Beta strandi30 – 37Combined sources8
Helixi49 – 59Combined sources11
Turni60 – 62Combined sources3
Beta strandi66 – 70Combined sources5
Helixi75 – 82Combined sources8
Beta strandi86 – 91Combined sources6
Helixi94 – 110Combined sources17
Beta strandi115 – 120Combined sources6
Helixi123 – 125Combined sources3
Helixi130 – 138Combined sources9
Turni144 – 146Combined sources3
Helixi149 – 159Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F3MX-ray2.40A1-160[»]
4NAHX-ray2.38A/B/C/D/E/F1-160[»]
4NATX-ray1.72A/B/C1-160[»]
4NAUX-ray2.33A/B/C1-160[»]
ProteinModelPortaliP63820.
SMRiP63820.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63820.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000006518.
KOiK00954.
OMAiEFQMALM.

Family and domain databases

CDDicd02163. PPAT. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P63820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTIAVIPG SFDPITYGHL DIIERSTDRF DEIHVCVLKN SKKEGTFSLE
60 70 80 90 100
ERMDLIEQSV KHLPNVKVHQ FSGLLVDYCE QVGAKTIIRG LRAVSDFEYE
110 120 130 140 150
LRLTSMNKKL NNEIETLYMM SSTNYSFISS SIVKEVAAYR ADISEFVPPY
160
VEKALKKKFK
Length:160
Mass (Da):18,371
Last modified:October 11, 2004 - v1
Checksum:i67B4E6F42DBC8D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94872.1.
RefSeqiWP_000401377.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94872; BAB94872; BAB94872.
GeneIDi28381325.
KEGGisam:MW1007.
PATRICi19568594. VBIStaAur44266_1056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94872.1.
RefSeqiWP_000401377.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F3MX-ray2.40A1-160[»]
4NAHX-ray2.38A/B/C/D/E/F1-160[»]
4NATX-ray1.72A/B/C1-160[»]
4NAUX-ray2.33A/B/C1-160[»]
ProteinModelPortaliP63820.
SMRiP63820.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94872; BAB94872; BAB94872.
GeneIDi28381325.
KEGGisam:MW1007.
PATRICi19568594. VBIStaAur44266_1056.

Phylogenomic databases

HOGENOMiHOG000006518.
KOiK00954.
OMAiEFQMALM.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Miscellaneous databases

EvolutionaryTraceiP63820.

Family and domain databases

CDDicd02163. PPAT. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAD_STAAW
AccessioniPrimary (citable) accession number: P63820
Secondary accession number(s): Q99UX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.