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P63815 (COAD_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphopantetheine adenylyltransferase

EC=2.7.7.3
Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT
Gene names
Name:coaD
Ordered Locus Names:BR1095, BS1330_I1091
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP-Rule MF_00151

Catalytic activity

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP-Rule MF_00151

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP-Rule MF_00151

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_00151

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00151.

Sequence similarities

Belongs to the bacterial CoaD family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantetheine-phosphate adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Phosphopantetheine adenylyltransferase HAMAP-Rule MF_00151
PRO_0000156183

Sequences

Sequence LengthMass (Da)Tools
P63815 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 73787866A6C89A5A

FASTA16417,399
        10         20         30         40         50         60 
MTIAIYAGSF DPVTNGHIDV LKGALRLADQ VIVAIGMHPG KKPLFSFDER VALIEASAKA 

        70         80         90        100        110        120 
VLHKDAARVS VIAFDGLVID AARKHGAQLM VRGLRDGTDL DYEMQMAGMN GTMAPELQTV 

       130        140        150        160 
FLPADPAVRT ITATLVRQIA SMGGDIKPFV PVAVAAALNT KFKS 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30015.1.
CP002997 Genomic DNA. Translation: AEM18433.1.
RefSeqNP_698100.1. NC_004310.3.
YP_005615925.1. NC_017251.1.

3D structure databases

ProteinModelPortalP63815.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1095.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30015; AAN30015; BR1095.
AEM18433; AEM18433; BS1330_I1091.
GeneID1166771.
12138124.
KEGGbms:BR1095.
bsi:BS1330_I1091.
PATRIC17790524. VBIBruSui107850_1116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0669.
HOGENOMHOG000006518.
KOK00954.
OMATMDFEYE.
OrthoDBEOG6MH5J7.

Enzyme and pathway databases

UniPathwayUPA00241; UER00355.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00151. PPAT_bact.
InterProIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
PRINTSPR01020. LPSBIOSNTHSS.
TIGRFAMsTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAD_BRUSU
AccessionPrimary (citable) accession number: P63815
Secondary accession number(s): G0KA17, Q8G0J8, Q8YHB6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names