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P63814

- COAD_BRUME

UniProt

P63814 - COAD_BRUME

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Protein

Phosphopantetheine adenylyltransferase

Gene
coaD, BMEI0886
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantetheine-phosphate adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferase (EC:2.7.7.3)
Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name:
PPAT
Gene namesi
Name:coaD
Ordered Locus Names:BMEI0886
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Phosphopantetheine adenylyltransferaseUniRule annotationPRO_0000156182Add
BLAST

Interactioni

Subunit structurei

Homohexamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0886.

Structurei

3D structure databases

ProteinModelPortaliP63814.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial CoaD family.

Phylogenomic databases

HOGENOMiHOG000006518.
KOiK00954.
OMAiHENVIEL.
OrthoDBiEOG6MH5J7.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact.
InterProiIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P63814-1 [UniParc]FASTAAdd to Basket

« Hide

MTIAIYAGSF DPVTNGHIDV LKGALRLADQ VIVAIGMHPG KKPLFSFDER    50
VALIEASAKA VLHKDAARVS VIAFDGLVID AARKHGAQLM VRGLRDGTDL 100
DYEMQMAGMN GTMAPELQTV FLPADPAVRT ITATLVRQIA SMGGDIKPFV 150
PVAVAAALNT KFKS 164
Length:164
Mass (Da):17,399
Last modified:October 11, 2004 - v1
Checksum:i73787866A6C89A5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52067.1.
PIRiAH3362.
RefSeqiNP_539803.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52067; AAL52067; BMEI0886.
GeneIDi1196597.
KEGGibme:BMEI0886.
PATRICi17801960. VBIBruMel146950_3300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52067.1 .
PIRi AH3362.
RefSeqi NP_539803.1. NC_003317.1.

3D structure databases

ProteinModelPortali P63814.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52067 ; AAL52067 ; BMEI0886 .
GeneIDi 1196597.
KEGGi bme:BMEI0886.
PATRICi 17801960. VBIBruMel146950_3300.

Phylogenomic databases

HOGENOMi HOG000006518.
KOi K00954.
OMAi HENVIEL.
OrthoDBi EOG6MH5J7.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00355 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00151. PPAT_bact.
InterProi IPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01467. CTP_transf_2. 1 hit.
[Graphical view ]
PRINTSi PR01020. LPSBIOSNTHSS.
TIGRFAMsi TIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCOAD_BRUME
AccessioniPrimary (citable) accession number: P63814
Secondary accession number(s): Q8G0J8, Q8YHB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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