Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantetheine-phosphate adenylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
Ordered Locus Names:BMEI0886
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Phosphopantetheine adenylyltransferasePRO_0000156182Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0886.

Structurei

3D structure databases

ProteinModelPortaliP63814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000006518.
KOiK00954.
OMAiRAMSDFE.
OrthoDBiEOG6MH5J7.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact.
InterProiIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P63814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIAIYAGSF DPVTNGHIDV LKGALRLADQ VIVAIGMHPG KKPLFSFDER
60 70 80 90 100
VALIEASAKA VLHKDAARVS VIAFDGLVID AARKHGAQLM VRGLRDGTDL
110 120 130 140 150
DYEMQMAGMN GTMAPELQTV FLPADPAVRT ITATLVRQIA SMGGDIKPFV
160
PVAVAAALNT KFKS
Length:164
Mass (Da):17,399
Last modified:October 11, 2004 - v1
Checksum:i73787866A6C89A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52067.1.
PIRiAH3362.
RefSeqiNP_539803.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52067; AAL52067; BMEI0886.
GeneIDi1196597.
KEGGibme:BMEI0886.
PATRICi17801960. VBIBruMel146950_3300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52067.1.
PIRiAH3362.
RefSeqiNP_539803.1. NC_003317.1.

3D structure databases

ProteinModelPortaliP63814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI0886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52067; AAL52067; BMEI0886.
GeneIDi1196597.
KEGGibme:BMEI0886.
PATRICi17801960. VBIBruMel146950_3300.

Phylogenomic databases

HOGENOMiHOG000006518.
KOiK00954.
OMAiRAMSDFE.
OrthoDBiEOG6MH5J7.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00151. PPAT_bact.
InterProiIPR004821. Cyt_trans-like.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
PRINTSiPR01020. LPSBIOSNTHSS.
TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCOAD_BRUME
AccessioniPrimary (citable) accession number: P63814
Secondary accession number(s): Q8G0J8, Q8YHB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.