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P63814

- COAD_BRUME

UniProt

P63814 - COAD_BRUME

Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

    Catalytic activityi

    ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantetheine-phosphate adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00241; UER00355.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
    Alternative name(s):
    Dephospho-CoA pyrophosphorylaseUniRule annotation
    Pantetheine-phosphate adenylyltransferaseUniRule annotation
    Short name:
    PPATUniRule annotation
    Gene namesi
    Name:coaDUniRule annotation
    Ordered Locus Names:BMEI0886
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Phosphopantetheine adenylyltransferasePRO_0000156182Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI0886.

    Structurei

    3D structure databases

    ProteinModelPortaliP63814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bacterial CoaD family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000006518.
    KOiK00954.
    OMAiHENVIEL.
    OrthoDBiEOG6MH5J7.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00151. PPAT_bact.
    InterProiIPR004821. Cyt_trans-like.
    IPR001980. LPS_biosynth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    [Graphical view]
    PRINTSiPR01020. LPSBIOSNTHSS.
    TIGRFAMsiTIGR01510. coaD_prev_kdtB. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P63814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIAIYAGSF DPVTNGHIDV LKGALRLADQ VIVAIGMHPG KKPLFSFDER    50
    VALIEASAKA VLHKDAARVS VIAFDGLVID AARKHGAQLM VRGLRDGTDL 100
    DYEMQMAGMN GTMAPELQTV FLPADPAVRT ITATLVRQIA SMGGDIKPFV 150
    PVAVAAALNT KFKS 164
    Length:164
    Mass (Da):17,399
    Last modified:October 11, 2004 - v1
    Checksum:i73787866A6C89A5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52067.1.
    PIRiAH3362.
    RefSeqiNP_539803.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52067; AAL52067; BMEI0886.
    GeneIDi1196597.
    KEGGibme:BMEI0886.
    PATRICi17801960. VBIBruMel146950_3300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52067.1 .
    PIRi AH3362.
    RefSeqi NP_539803.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali P63814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0886.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52067 ; AAL52067 ; BMEI0886 .
    GeneIDi 1196597.
    KEGGi bme:BMEI0886.
    PATRICi 17801960. VBIBruMel146950_3300.

    Phylogenomic databases

    HOGENOMi HOG000006518.
    KOi K00954.
    OMAi HENVIEL.
    OrthoDBi EOG6MH5J7.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00355 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00151. PPAT_bact.
    InterProi IPR004821. Cyt_trans-like.
    IPR001980. LPS_biosynth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01020. LPSBIOSNTHSS.
    TIGRFAMsi TIGR01510. coaD_prev_kdtB. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiCOAD_BRUME
    AccessioniPrimary (citable) accession number: P63814
    Secondary accession number(s): Q8G0J8, Q8YHB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3