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P63808 (COAA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate kinase

EC=2.7.1.33
Alternative name(s):
Pantothenic acid kinase
Gene names
Name:coaA
Ordered Locus Names:BMEI2039
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_00215

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_00215

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00215.

Sequence similarities

Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pantothenate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Pantothenate kinase HAMAP-Rule MF_00215
PRO_0000194421

Regions

Nucleotide binding100 – 1078ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P63808 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: D3EFE78CC7FC7D0B

FASTA32237,477
        10         20         30         40         50         60 
MWEKVDQLTP SRYSPYRFFS AQEWAAFRAD TPLTLTYEEV KRLRSLGDPI DLDEVRRIYL 

        70         80         90        100        110        120 
SLSRLLYAHV EASQLLFRQR QQFLNMEESY KTPFIIGVAG SVAVGKSTMA RILKELLARW 

       130        140        150        160        170        180 
PSSPKVDLVT TDGFLYPNAV LREQNMMERK GFPESYDIGA VLRFLSAIKA GMSRVRAPLY 

       190        200        210        220        230        240 
SHLSYDVLPG EYQIVDKPDI LIFEGINVLQ VRDLPEDGKM VPFVSDFFDF SIYIDADPRL 

       250        260        270        280        290        300 
IHKWYIDRFM RLRETAFRDP QSFFHRYSQL SQEAARSIAE GLWQNINLKN LNENILPTRP 

       310        320 
RADLILRKGS DHLIEEVALR KI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL53220.1.
PIRAI3506.
RefSeqNP_540956.1. NC_003317.1.

3D structure databases

ProteinModelPortalP63808.
SMRP63808. Positions 12-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI2039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL53220; AAL53220; BMEI2039.
GeneID1197750.
KEGGbme:BMEI2039.
PATRIC17795755. VBIBruMel146950_1149.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000248571.
KOK00867.
OMALMQRKGF.
OrthoDBEOG62C9GX.
ProtClustDBPRK05439.

Enzyme and pathway databases

UniPathwayUPA00241; UER00352.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00215. Pantothen_kinase_1.
InterProIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERPTHR10285:SF7. PTHR10285:SF7. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PIRSFPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00554. panK_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAA_BRUME
AccessionPrimary (citable) accession number: P63808
Secondary accession number(s): Q8YE39
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names