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Protein

Pantothenate kinase

Gene

coaA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. pantothenate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:BMEI2039
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Pantothenate kinasePRO_0000194421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI2039.

Structurei

3D structure databases

ProteinModelPortaliP63808.
SMRiP63808. Positions 12-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiWPEHPRV.
OrthoDBiEOG62C9GX.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 1 hit.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

P63808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWEKVDQLTP SRYSPYRFFS AQEWAAFRAD TPLTLTYEEV KRLRSLGDPI
60 70 80 90 100
DLDEVRRIYL SLSRLLYAHV EASQLLFRQR QQFLNMEESY KTPFIIGVAG
110 120 130 140 150
SVAVGKSTMA RILKELLARW PSSPKVDLVT TDGFLYPNAV LREQNMMERK
160 170 180 190 200
GFPESYDIGA VLRFLSAIKA GMSRVRAPLY SHLSYDVLPG EYQIVDKPDI
210 220 230 240 250
LIFEGINVLQ VRDLPEDGKM VPFVSDFFDF SIYIDADPRL IHKWYIDRFM
260 270 280 290 300
RLRETAFRDP QSFFHRYSQL SQEAARSIAE GLWQNINLKN LNENILPTRP
310 320
RADLILRKGS DHLIEEVALR KI
Length:322
Mass (Da):37,477
Last modified:October 11, 2004 - v1
Checksum:iD3EFE78CC7FC7D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL53220.1.
PIRiAI3506.
RefSeqiNP_540956.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL53220; AAL53220; BMEI2039.
KEGGibme:BMEI2039.
PATRICi17795755. VBIBruMel146950_1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL53220.1.
PIRiAI3506.
RefSeqiNP_540956.1. NC_003317.1.

3D structure databases

ProteinModelPortaliP63808.
SMRiP63808. Positions 12-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI2039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53220; AAL53220; BMEI2039.
KEGGibme:BMEI2039.
PATRICi17795755. VBIBruMel146950_1149.

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiWPEHPRV.
OrthoDBiEOG62C9GX.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 1 hit.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCOAA_BRUME
AccessioniPrimary (citable) accession number: P63808
Secondary accession number(s): Q8YE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.