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P63808

- COAA_BRUME

UniProt

P63808 - COAA_BRUME

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Protein
Pantothenate kinase
Gene
coaA, BMEI2039
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. pantothenate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase
Gene namesi
Name:coaA
Ordered Locus Names:BMEI2039
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Pantothenate kinaseUniRule annotation
PRO_0000194421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI2039.

Structurei

3D structure databases

ProteinModelPortaliP63808.
SMRiP63808. Positions 12-322.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248571.
KOiK00867.
OMAiENLMERK.
OrthoDBiEOG62C9GX.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 1 hit.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

P63808-1 [UniParc]FASTAAdd to Basket

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MWEKVDQLTP SRYSPYRFFS AQEWAAFRAD TPLTLTYEEV KRLRSLGDPI    50
DLDEVRRIYL SLSRLLYAHV EASQLLFRQR QQFLNMEESY KTPFIIGVAG 100
SVAVGKSTMA RILKELLARW PSSPKVDLVT TDGFLYPNAV LREQNMMERK 150
GFPESYDIGA VLRFLSAIKA GMSRVRAPLY SHLSYDVLPG EYQIVDKPDI 200
LIFEGINVLQ VRDLPEDGKM VPFVSDFFDF SIYIDADPRL IHKWYIDRFM 250
RLRETAFRDP QSFFHRYSQL SQEAARSIAE GLWQNINLKN LNENILPTRP 300
RADLILRKGS DHLIEEVALR KI 322
Length:322
Mass (Da):37,477
Last modified:October 11, 2004 - v1
Checksum:iD3EFE78CC7FC7D0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL53220.1.
PIRiAI3506.
RefSeqiNP_540956.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL53220; AAL53220; BMEI2039.
GeneIDi1197750.
KEGGibme:BMEI2039.
PATRICi17795755. VBIBruMel146950_1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL53220.1 .
PIRi AI3506.
RefSeqi NP_540956.1. NC_003317.1.

3D structure databases

ProteinModelPortali P63808.
SMRi P63808. Positions 12-322.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224914.BMEI2039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53220 ; AAL53220 ; BMEI2039 .
GeneIDi 1197750.
KEGGi bme:BMEI2039.
PATRICi 17795755. VBIBruMel146950_1149.

Phylogenomic databases

HOGENOMi HOG000248571.
KOi K00867.
OMAi ENLMERK.
OrthoDBi EOG62C9GX.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00352 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00215. Pantothen_kinase_1.
InterProi IPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view ]
PANTHERi PTHR10285:SF7. PTHR10285:SF7. 1 hit.
Pfami PF00485. PRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00554. panK_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCOAA_BRUME
AccessioniPrimary (citable) accession number: P63808
Secondary accession number(s): Q8YE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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