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Protein

Cytidylate kinase

Gene

cmk

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:cmkUniRule annotation
Ordered Locus Names:MW1366
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001319771 – 219Cytidylate kinaseAdd BLAST219

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Helixi16 – 26Combined sources11
Beta strandi30 – 33Combined sources4
Helixi34 – 47Combined sources14
Helixi54 – 59Combined sources6
Beta strandi63 – 67Combined sources5
Beta strandi73 – 77Combined sources5
Helixi83 – 85Combined sources3
Beta strandi86 – 89Combined sources4
Helixi90 – 99Combined sources10
Helixi102 – 116Combined sources15
Beta strandi121 – 127Combined sources7
Helixi128 – 132Combined sources5
Beta strandi137 – 143Combined sources7
Helixi146 – 159Combined sources14
Helixi166 – 182Combined sources17
Beta strandi184 – 186Combined sources3
Beta strandi195 – 198Combined sources4
Helixi204 – 216Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H92X-ray2.30A/B/C1-219[»]
ProteinModelPortaliP63807.
SMRiP63807.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63807.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.

Sequencei

Sequence statusi: Complete.

P63807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAINIALDG PAAAGKSTIA KRVASELSMI YVDTGAMYRA LTYKYLKLNK
60 70 80 90 100
TEDFAKLVDQ TTLDLTYKAD KGQCVILDNE DVTDFLRNND VTQHVSYVAS
110 120 130 140 150
KEPVRSFAVK KQKELAAEKG IVMDGRDIGT VVLPDADLKV YMIASVEERA
160 170 180 190 200
ERRYKDNQLR GIESNFEDLK RDIEARDQYD MNREISPLRK ADDAVTLDTT
210
GKSIEEVTDE ILAMVSQIK
Length:219
Mass (Da):24,595
Last modified:October 11, 2004 - v1
Checksum:i5C4671129BFDFE46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95231.1.
RefSeqiWP_000644391.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95231; BAB95231; BAB95231.
GeneIDi28380938.
KEGGisam:MW1366.
PATRICi19569340. VBIStaAur44266_1431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95231.1.
RefSeqiWP_000644391.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H92X-ray2.30A/B/C1-219[»]
ProteinModelPortaliP63807.
SMRiP63807.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95231; BAB95231; BAB95231.
GeneIDi28380938.
KEGGisam:MW1366.
PATRICi19569340. VBIStaAur44266_1431.

Phylogenomic databases

HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.

Miscellaneous databases

EvolutionaryTraceiP63807.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCY_STAAW
AccessioniPrimary (citable) accession number: P63807
Secondary accession number(s): Q99U12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.