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Protein

Cardiolipin synthase

Gene

cls

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei234UniRule annotation1
Active sitei236UniRule annotation1
Active sitei241UniRule annotation1
Active sitei412UniRule annotation1
Active sitei414UniRule annotation1
Active sitei419UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthaseUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:cls
Ordered Locus Names:SAV2088
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012691 – 494Cardiolipin synthaseAdd BLAST494

Proteomic databases

PaxDbiP63800.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2088.

Structurei

3D structure databases

ProteinModelPortaliP63800.
SMRiP63800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 256PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini407 – 434PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000077402.
KOiK06131.
OMAiICSVGTA.
PhylomeDBiP63800.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls. 1 hit.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELLSIALK HSNIILNSIF IGAFILNLLF AFTIIFMERR SANSIWAWLL
60 70 80 90 100
VLVFLPLFGF ILYLLLGRQI QRDQIFKIDK EDKKGLELIV DEQLAALKNE
110 120 130 140 150
NFSNSNYQIV KFKEMIQMLL YNNAAFLTTD NDLKIYTDGQ EKFDDLIQDI
160 170 180 190 200
RNATDYIHFQ YYIIQNDELG RTILNELGKK AEQGVEVKIL YDDMGSRGLR
210 220 230 240 250
KKGLRPFRNK GGHAEAFFPS KLPLINLRMN NRNHRKIVVI DGQIGYVGGF
260 270 280 290 300
NVGDEYLGKS KKFGYWRDTH LRIVGDAVNA LQLRFILDWN SQATRDHISY
310 320 330 340 350
DDRYFPDVNS GGTIGVQIAS SGPDEEWEQI KYGYLKMISS AKKSIYIQSP
360 370 380 390 400
YFIPDQAFLD SIKIAALGGV DVNIMIPNKP DHPFVFWATL KNAASLLDAG
410 420 430 440 450
VKVFHYDNGF LHSKTLVIDD EIASVGTANM DHRSFTLNFE VNAFIYDQQI
460 470 480 490
AKKLKQAFID DLAVSSELTK ARYAKRSLWI KFKEGISQLL SPIL
Length:494
Mass (Da):56,518
Last modified:October 11, 2004 - v1
Checksum:i81A5D9B7F098990B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58250.1.
RefSeqiWP_000571549.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58250; BAB58250; SAV2088.
GeneIDi28380329.
KEGGisav:SAV2088.
PATRICi19565054. VBIStaAur52173_2162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58250.1.
RefSeqiWP_000571549.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP63800.
SMRiP63800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2088.

Proteomic databases

PaxDbiP63800.

Protocols and materials databases

DNASUi1122105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58250; BAB58250; SAV2088.
GeneIDi28380329.
KEGGisav:SAV2088.
PATRICi19565054. VBIStaAur52173_2162.

Phylogenomic databases

eggNOGiENOG4105CQX. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000077402.
KOiK06131.
OMAiICSVGTA.
PhylomeDBiP63800.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls. 1 hit.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLS_STAAM
AccessioniPrimary (citable) accession number: P63800
Secondary accession number(s): Q99SG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.